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ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier.

Abstract : The ST6GALNAC5 gene that encodes an α2,6-sialyltransferase involved in the biosynthesis of α-series gangliosides, was previously identified as one of the genes that mediate breast cancer metastasis to the brain. We have shown that the expression of ST6GALNAC5 in MDA-MB-231 breast cancer cells resulted in the expression of GD1α ganglioside at the cell surface. By using a human blood-brain barrier in vitro model recently developed, consisting in CD34⁺ derived endothelial cells co-cultivated with pericytes, we show that ST6GALNAC5 expression decreased the interactions between the breast cancer cells and the human blood-brain barrier.
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https://hal.archives-ouvertes.fr/hal-01358166
Contributor : Philippe Delannoy <>
Submitted on : Wednesday, July 21, 2021 - 9:52:46 AM
Last modification on : Thursday, July 22, 2021 - 3:41:48 PM

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Aurore Drolez, Elodie Vandenhaute, Clément Philippe Delannoy, Justine Hélène Dewald, Fabien Gosselet, et al.. ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier.. International Journal of Molecular Sciences, MDPI, 2015, 17 (8), pp.1309. ⟨10.3390/ijms17081309⟩. ⟨hal-01358166⟩

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