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Mouse models of peanut allergy Contribution of oral and nasal sensitization to allergic reactions to peanut and cross-reactivity with food and environmental antigens

Romy Fischer
Abstract : Food-allergic patients can develop adverse reactions to members of the same and even unrelated botanical families. IgE and Th2-type responses play an important role in allergic reactions although it is now clear that these reactions involve other cellular and molecular interactions. We investigated the role played by the mucosal sites of initial priming to peanut on subsequent immune responses to peanut and reactivity to airway antigen challenge. For this purpose, we analyzed antibody responses to peanut immunization, as well as cytokine and airway responses to nasal antigen challenge in mice orally or nasally sensitized to peanut in the presence of cholera toxin. Oral peanut sensitization induced higher levels of IgE but lower IgG responses than nasal immunization. Both mice sensitized orally and nasally to peanut experienced airway hyper-reactivity upon nasal peanut challenge. However, orally sensitized mice exhibited higher levels of lung eosinophilia and IL-4 in response to peanut challenge. In contrast, higher levels of lung MAC-1+ cells and inflammatory cytokines were seen in nasally sensitized mice. Finally, nasal but not oral sensitization promoted lung inflammatory responses to unrelated antigens. These findings suggest that the initial route of sensitization influence the responses of peanut allergic individuals to airborne antigens and allergens.
Keywords : Peanut Allergy Mouse
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Submitted on : Thursday, February 28, 2008 - 8:00:00 AM
Last modification on : Thursday, February 28, 2008 - 8:00:00 AM
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Romy Fischer. Mouse models of peanut allergy Contribution of oral and nasal sensitization to allergic reactions to peanut and cross-reactivity with food and environmental antigens. Life Sciences [q-bio]. INAPG (AgroParisTech), 2005. English. ⟨NNT : 2005INAP0011⟩. ⟨pastel-00001725⟩

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