V. Turcanu, S. Maleki, and G. Lack, Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts, Journal of Clinical Investigation, vol.111, issue.7, pp.1065-1072, 2003.
DOI : 10.1172/JCI200316142

S. Hefle, R. Helm, A. Burks, and R. Bush, Comparison of commercial peanut skin test extracts, Journal of Allergy and Clinical Immunology, vol.95, issue.4, pp.837-842, 1995.
DOI : 10.1016/S0091-6749(95)70127-3

L. Parisot, C. Aparicio, D. Moneret-vautrin, and L. Guerin, Allergy to lupine flour, Allergy, vol.52, issue.9, pp.918-919, 2001.
DOI : 10.1034/j.1398-9995.2001.00254.x

S. Hefle, R. Lemanske, J. Bush, and R. , Adverse reaction to lupine-fortified pasta, Journal of Allergy and Clinical Immunology, vol.94, issue.2, pp.167-172, 1994.
DOI : 10.1053/ai.1994.v94.a54942

D. Moneret-vautrin, L. Guerin, G. Kanny, J. Flabbee, S. Fremont et al., Cross-allergenicity of peanut and lupine: The risk of lupine allergy in patients allergic to peanuts, Journal of Allergy and Clinical Immunology, vol.104, issue.4, pp.883-888, 1999.
DOI : 10.1016/S0091-6749(99)70303-9

H. Sampson and C. Mccaskill, Food hypersensitivity and atopic dermatitis: Evaluation of 113 patients, The Journal of Pediatrics, vol.107, issue.5, pp.669-675, 1985.
DOI : 10.1016/S0022-3476(85)80390-5

H. Sampson, Food Hypersensitivity as a Pathogenic Factor in Atopic Dermatitis, Allergy and Asthma Proceedings, vol.7, issue.6, pp.511-519, 1986.
DOI : 10.2500/108854186779045412

D. Gutierrez, A. Conde, S. Duran, J. Delgado, P. Guardia et al., Contact urticaria form lupin, Contact urticaria from lupin, p.311, 1997.
DOI : 10.1111/j.1600-0536.1997.tb00012.x

C. Romano, A. Ferrara, and P. Falagiani, A case of allergy to globe artichoke and other clinical cases of rare food allergy, J Investig Allergol Clin Immunol, vol.10, pp.102-104, 2000.

D. Barnett, B. Bonham, and M. Howden, Allergenic cross-reactions among legume foods???An in vitro study, Journal of Allergy and Clinical Immunology, vol.79, issue.3, pp.433-438, 1987.
DOI : 10.1016/0091-6749(87)90359-9

J. Bernhisel-broadbent, S. Taylor, and H. Sampson, Cross-allergenicity in the legume botanical family in children with food hypersensitivity *1, *2II. Laboratory correlates, Journal of Allergy and Clinical Immunology, vol.84, issue.5, pp.701-709, 1989.
DOI : 10.1016/0091-6749(89)90298-4

S. Bock and F. Atkins, Patterns of food hypersensitivity during sixteen years of double-blind, placebo-controlled food challenges, The Journal of Pediatrics, vol.117, issue.4, pp.561-567, 1990.
DOI : 10.1016/S0022-3476(05)80689-4

A. Burks, J. James, A. Hiegel, G. Wilson, J. Wheeler et al., Atopic dermatitis and food hypersensitivity reactions, The Journal of Pediatrics, vol.132, issue.1, pp.132-136, 1998.
DOI : 10.1016/S0022-3476(98)70498-6

T. Foucard, M. Yman, and I. , A study on severe food reactions in Sweden--is soy protein an underestimated cause of food anaphylaxis? Allergy, pp.261-265, 1999.

S. Sicherer, H. Sampson, and A. Burks, Peanut and soy allergy: a clinical and therapeutic dilemma, Allergy, vol.103, issue.6, pp.515-521, 2000.
DOI : 10.1034/j.1398-9995.2000.00119.x

V. Matheu, M. De-barrio, Z. Sierra, M. Gracia-bara, P. Tornero et al., Lupine-induced anaphylaxis, Annals of Allergy, Asthma & Immunology, vol.83, issue.5, pp.406-408, 1999.
DOI : 10.1016/S1081-1206(10)62838-4

G. Kanny, L. Guerin, and D. Moneret-vautrin, Le risque d'asthme aigu grave ?? la farine de lupin associ?? ?? l'allergie ?? l'arachide, La Revue de M??decine Interne, vol.21, issue.2, pp.191-194, 2000.
DOI : 10.1016/S0248-8663(00)88250-8

T. Perry, M. Conover-walker, A. Pomes, M. Chapman, and R. Wood, Distribution of peanut allergen in the environment, Journal of Allergy and Clinical Immunology, vol.113, issue.5, pp.973-976, 2004.
DOI : 10.1016/j.jaci.2004.02.035

R. Woods, F. Thien, R. J. Walters, E. Abramson, and M. , Prevalence of food allergies in young adults and their relationship to asthma, nasal allergies, and eczema, Annals of Allergy, Asthma & Immunology, vol.88, issue.2, pp.183-189, 2002.
DOI : 10.1016/S1081-1206(10)61994-1

H. Sampson, L. Mendelson, and J. Rosen, Fatal and Near-Fatal Anaphylactic Reactions to Food in Children and Adolescents, New England Journal of Medicine, vol.327, issue.6, pp.380-384, 1992.
DOI : 10.1056/NEJM199208063270603

G. Roberts, N. Patel, F. Levi-schaffer, P. Habibi, and G. Lack, Food allergy as a risk factor for life-threatening asthma in childhood: A case-controlled study, Journal of Allergy and Clinical Immunology, vol.112, issue.1, pp.168-174, 2003.
DOI : 10.1067/mai.2003.1569

P. Vadas, Y. Wai, W. Burks, and B. Perelman, Detection of Peanut Allergens in Breast Milk of Lactating Women, JAMA, vol.285, issue.13, pp.1746-1748, 2001.
DOI : 10.1001/jama.285.13.1746

J. Crespo, C. Pascual, A. Vallecillo, and M. Esteban, Sensitization to Inhalant Allergens in Children Diagnosed with Food Hypersensitivity, Allergy and Asthma Proceedings, vol.16, issue.2, pp.89-92, 1995.
DOI : 10.2500/108854195778771381

N. Eriksson, H. Formgren, and E. Svenonius, Food Hypersensitivity in Patients with Pollen Allergy, Allergy, vol.34, issue.6, pp.437-443, 1982.
DOI : 10.1111/j.1600-0536.1977.tb03603.x

E. Enrique, A. Cistero-bahima, B. Bartolome, R. Alonso, S. Miguel-moncin et al., Platanus acerifolia pollinosis and food allergy, Allergy, vol.57, issue.4, pp.351-356, 2002.
DOI : 10.1067/mai.2001.113864

S. Vieths, S. Scheurer, and B. Ballmer-weber, Current Understanding of Cross-Reactivity of Food Allergens and Pollen, Annals of the New York Academy of Sciences, vol.103, issue.1, pp.47-68, 2002.
DOI : 10.1111/j.1749-6632.2002.tb04132.x

R. Asero, G. Mistrello, D. Roncarolo, S. Amato, G. Caldironi et al., Immunological cross-reactivity between lipid transfer proteins from botanically unrelated plant-derived foods: a clinical study, Allergy, vol.87, issue.10, pp.900-906, 2002.
DOI : 10.1105/tpc.3.9.907

M. Wensing, J. Akkerdaas, W. Van-leeuwen, S. Stapel, C. Bruijnzeel-koomen et al., IgE to Bet v 1 and profilin: Cross-reactivity patterns and clinical relevance, Journal of Allergy and Clinical Immunology, vol.110, issue.3, pp.435-442, 2002.
DOI : 10.1067/mai.2002.126380

A. Mishra, S. Hogan, E. Brandt, and M. Rothenberg, An etiological role for aeroallergens and eosinophils in experimental esophagitis, Journal of Clinical Investigation, vol.107, issue.1, pp.83-90, 2001.
DOI : 10.1172/JCI10224

E. Pastorello, C. Incorvaia, V. Pravettoni, and C. Ortolani, Crossreactions in food allergy, Clinical Reviews in Allergy & Immunology, vol.94, issue.4, pp.415-427, 1997.
DOI : 10.1007/BF02737737

R. Helm, Food allergy: in-vivo diagnostics including challenge, Current Opinion in Allergy and Clinical Immunology, vol.1, issue.3, pp.255-259, 2001.
DOI : 10.1097/00130832-200106000-00010

B. Niggemann, B. Sielaff, K. Beyer, C. Binder, and U. Wahn, Outcome of double-blind, placebo-controlled food challenge tests in 107 children with atopic dermatitis, Clinical & Experimental Allergy, vol.59, issue.1, pp.91-96, 1999.
DOI : 10.1046/j.1365-2222.1999.00454.x

H. Sampson, Immunologically mediated food allergy: the importance of food challenge procedures, Ann Allergy, vol.60, pp.262-269, 1988.

D. Hamilos, J. Oppenheimer, H. Nelson, S. Wenzel, S. Driscoll et al., Suggested approaches for research protocols involving the potential for life-threatening reactions, Journal of Allergy and Clinical Immunology, vol.91, issue.6, pp.1101-1120, 1993.
DOI : 10.1016/0091-6749(93)90312-4

S. Bock, W. Lee, and L. Remigio, Studies of hypersensitivity reactions to foods in infants and children, Journal of Allergy and Clinical Immunology, vol.62, issue.6, pp.327-334, 1978.
DOI : 10.1016/0091-6749(78)90132-X

C. May, Objective clinical and laboratory studies of immediate hypersensitivity reactions to foods in asthmatic children, Journal of Allergy and Clinical Immunology, vol.58, issue.4, pp.500-515, 1976.
DOI : 10.1016/0091-6749(76)90194-9

H. Sampson and R. Albergo, Comparison of results of skin tests, RAST, and double-blind, placebo-controlled food challenges in children with atopic dermatitis, Journal of Allergy and Clinical Immunology, vol.74, issue.1, pp.26-33, 1984.
DOI : 10.1016/0091-6749(84)90083-6

M. Devey, K. Anderson, R. Coombs, M. Henschel, and M. Coates, The modified anaphylaxis hypothesis for cot death Anaphylactic sensitization in guinea-pigs fed cow's milk, Clin Exp Immunol, vol.26, pp.542-548, 1976.

Z. Ovary, N. Vaz, and N. Warner, Passive anaphylaxis in mice with gamma-G antibodies. V. Competitive effects of different immunoglobulins and inhibition of reactions with antiglobulin sera, pp.715-727, 1970.

S. Hogan, A. Mishra, E. Brandt, P. Foster, and M. Rothenberg, A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy, Proceedings of the National Academy of Sciences, vol.97, issue.12, pp.6681-6686, 2000.
DOI : 10.1073/pnas.97.12.6681

S. Bae, Y. Tanaka, J. Hakugawa, and I. Katayama, Interleukin-5 involvement in ovalbumin-induced eosinophil infiltration in mouse food-allergy model, Journal of Dermatological Science, vol.21, issue.1, pp.1-7, 1999.
DOI : 10.1016/S0923-1811(98)00082-6

M. Kweon, M. Yamamoto, M. Kajiki, I. Takahashi, and H. Kiyono, Systemically derived large intestinal CD4+ Th2 cells play a central role in STAT6-mediated allergic diarrhea, Journal of Clinical Investigation, vol.106, issue.2, pp.199-206, 2000.
DOI : 10.1172/JCI8490

S. Strobel and A. Mowat, Immune responses to dietary antigens: oral tolerance, Immunology Today, vol.19, issue.4, pp.173-181, 1998.
DOI : 10.1016/S0167-5699(97)01239-5

X. Li, B. Schofield, C. Huang, G. Kleiner, and H. Sampson, A murine model of IgE-mediated cow???s milk hypersensitivity, Journal of Allergy and Clinical Immunology, vol.103, issue.2, pp.206-214, 1999.
DOI : 10.1016/S0091-6749(99)70492-6

X. Li, D. Serebrisky, S. Lee, C. Huang, L. Bardina et al., A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses, Journal of Allergy and Clinical Immunology, vol.106, issue.1, pp.150-158, 2000.
DOI : 10.1067/mai.2000.107395

V. Morafo, K. Srivastava, C. Huang, G. Kleiner, S. Lee et al., Genetic susceptibility to food allergy is linked to differential TH2-TH1 responses in C3H/HeJ and BALB/c mice, Journal of Allergy and Clinical Immunology, vol.111, issue.5, pp.1122-1128, 2003.
DOI : 10.1067/mai.2003.1463

S. Lee, C. Huang, T. Zhang, B. Schofield, A. Burks et al., Oral Administration of IL-12 Suppresses Anaphylactic Reactions in a Murine Model of Peanut Hypersensitivity, Clinical Immunology, vol.101, issue.2, pp.220-228, 2001.
DOI : 10.1006/clim.2001.5122

X. Li, K. Srivastava, J. Huleatt, K. Bottomly, A. Burks et al., Engineered Recombinant Peanut Protein and Heat-Killed Listeria monocytogenes Coadministration Protects Against Peanut-Induced Anaphylaxis in a Murine Model, The Journal of Immunology, vol.170, issue.6, pp.3289-3295, 2003.
DOI : 10.4049/jimmunol.170.6.3289

S. White, Food hypersensitivity in 30 dogs, J Am Vet Med Assoc, vol.188, pp.695-698, 1986.

R. Ermel, M. Kock, S. Griffey, G. Reinhart, and O. Frick, The atopic dog: a model for food allergy, Lab Anim Sci, vol.47, pp.40-49, 1997.

F. Klobasa, J. Butler, and F. Habe, Maternal-neonatal immunoregulation: suppression of de novo synthesis of IgG and IgA, but not IgM, in neonatal pigs by bovine colostrum, is lost upon storage, Am J Vet Res, vol.51, pp.1407-1412, 1990.

L. Heppell, J. Sissons, and S. Banks, Sensitisation of preruminant calves and piglets to antigenic protein in early weaning diets: control of the systemic antibody responses, Res Vet Sci, vol.47, pp.257-262, 1989.

S. Bergstedt-lindqvist, H. Moon, U. Persson, G. Moller, C. Heusser et al., Interleukin 4 instructs uncommitted B lymphocytes to switch to IgGl and IgE, European Journal of Immunology, vol.139, issue.7, pp.1073-1077, 1988.
DOI : 10.1002/eji.1830180716

E. Hamelmann, K. Takeda, A. Haczku, G. Cieslewicz, L. Shultz et al., Interleukin (IL)-5 but Not Immunoglobulin E Reconstitutes Airway Inflammation and Airway Hyperresponsiveness in IL-4???Deficient Mice, American Journal of Respiratory Cell and Molecular Biology, vol.23, issue.3, pp.327-334, 2000.
DOI : 10.1165/ajrcmb.23.3.3796

C. Herrick, H. Macleod, E. Glusac, R. Tigelaar, and K. Bottomly, Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4, Journal of Clinical Investigation, vol.105, issue.6, pp.765-775, 2000.
DOI : 10.1172/JCI8624

R. Kuhn, K. Rajewsky, and W. Muller, Generation and analysis of interleukin-4 deficient mice, Science, vol.254, issue.5032, pp.707-710, 1991.
DOI : 10.1126/science.1948049

A. Metwali, D. Elliott, A. Blum, J. Li, M. Sandor et al., The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice, J Immunol, vol.157, pp.4546-4553, 1996.

N. Okahashi, M. Yamamoto, J. Vancott, S. Chatfield, M. Roberts et al., Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses, Infect Immun, vol.64, pp.1516-1525, 1996.

M. Vajdy, M. Kosco-vilbois, M. Kopf, G. Kohler, and N. Lycke, Impaired mucosal immune responses in interleukin 4-targeted mice, Journal of Experimental Medicine, vol.181, issue.1, pp.41-53, 1995.
DOI : 10.1084/jem.181.1.41

G. Mckenzie, P. Fallon, C. Emson, R. Grencis, and A. Mckenzie, Simultaneous Disruption of Interleukin (IL)-4 and IL-13 Defines Individual Roles in T Helper Cell Type 2???mediated Responses, The Journal of Experimental Medicine, vol.154, issue.10, pp.1565-1572, 1999.
DOI : 10.1126/science.282.5397.2261

S. Wenzel, L. Schwartz, E. Langmack, J. Halliday, J. Trudeau et al., Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics, American Journal of Respiratory and Critical Care Medicine, vol.160, issue.3, pp.1001-1008, 1999.
DOI : 10.1164/ajrccm.160.3.9812110

U. Herz, H. Renz, and U. Wiedermann, Animal models of type I allergy using recombinant allergens, Methods, vol.32, issue.3, pp.271-280, 2004.
DOI : 10.1016/j.ymeth.2003.08.013

J. Kips, G. Anderson, J. Fredberg, U. Herz, M. Inman et al., Murine models of asthma, Murine models of asthma, pp.374-382, 2003.
DOI : 10.1183/09031936.03.00026403

T. Huang, P. Macary, P. Eynott, A. Moussavi, K. Daniel et al., Allergen-Specific Th1 Cells Counteract Efferent Th2 Cell-Dependent Bronchial Hyperresponsiveness and Eosinophilic Inflammation Partly Via IFN-??, The Journal of Immunology, vol.166, issue.1, pp.207-217, 2001.
DOI : 10.4049/jimmunol.166.1.207

A. Takaoka, Y. Tanaka, T. Tsuji, T. Jinushi, A. Hoshino et al., A Critical Role for Mouse CXC Chemokine(s) in Pulmonary Neutrophilia During Th Type 1-Dependent Airway Inflammation, The Journal of Immunology, vol.167, issue.4, pp.2349-2353, 2001.
DOI : 10.4049/jimmunol.167.4.2349

M. Mcdermott and J. Bienenstock, Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory, and genital tissues, J Immunol, vol.122, pp.1892-1898, 1979.

B. Forrest, J. Labrooy, P. Robinson, C. Dearlove, and D. Shearman, Specific immune response in the human respiratory tract following oral immunization with live typhoid vaccine, Infect Immun, vol.59, pp.1206-1209, 1991.
DOI : 10.1007/978-94-009-1848-1_94

K. Hyland, D. Foss, C. Johnson, and M. Murtaugh, Oral immunization induces local and distant mucosal immunity in swine, Veterinary Immunology and Immunopathology, vol.102, issue.3, pp.329-338, 2004.
DOI : 10.1016/j.vetimm.2004.09.015

X. Liang, M. Lamm, and J. Nedrud, Oral administration of cholera toxin-Sendai virus conjugate potentiates gut and respiratory immunity against Sendai virus, J Immunol, vol.141, pp.1495-1501, 1988.

C. Ruedl, C. Rieser, N. Kofler, G. Wick, and H. Wolf, Humoral and cellular immune responses in the murine respiratory tract following oral immunization with cholera toxin or Escherichia coli heat-labile enterotoxin, Vaccine, pp.792-798, 1996.

Y. Riffo-vasquez and D. Spina, Role of cytokines and chemokines in bronchial hyperresponsiveness and airway inflammation, Pharmacology & Therapeutics, vol.94, issue.3, pp.185-211, 2002.
DOI : 10.1016/S0163-7258(02)00217-6

M. Jenmalm, B. Bjorksten, C. Macaubas, B. Holt, T. Smallacombe et al., Allergen-induced cytokine secretion in relation to atopic symptoms and immunoglobulin E and immunoglobulin G subclass antibody responses, Pediatr Allergy Immunol, pp.168-177, 1999.

R. Seder, R. Gazzinelli, A. Sher, and W. Paul, Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming., Proceedings of the National Academy of Sciences, vol.90, issue.21, pp.10188-10192, 1993.
DOI : 10.1073/pnas.90.21.10188

H. Okamura, H. Tsutsi, T. Komatsu, M. Yutsudo, A. Hakura et al., Cloning of a new cytokine that induces IFN-?? production by T cells, Nature, vol.378, issue.6552, pp.88-91, 1995.
DOI : 10.1038/378088a0

G. Hansen, G. Berry, R. Dekruyff, and D. Umetsu, Allergen-specific Th1 cells fail to counterbalance Th2 cell???induced airway hyperreactivity but cause severe airway inflammation, Journal of Clinical Investigation, vol.103, issue.2, pp.175-183, 1999.
DOI : 10.1172/JCI5155

F. Heinzel, A. Hujer, F. Ahmed, and R. Rerko, In vivo production and function of IL-12 p40 homodimers, J Immunol, vol.158, pp.4381-4388, 1997.

A. Hino, M. Kweon, K. Fujihashi, J. Mcghee, and H. Kiyono, Pathological Role of Large Intestinal IL-12p40 for the Induction of Th2-Type Allergic Diarrhea, The American Journal of Pathology, vol.164, issue.4, pp.1327-1335, 2004.
DOI : 10.1016/S0002-9440(10)63219-1

C. Chen, C. Lee, Y. Liu, J. Wang, H. Lei et al., House Dust Mite Dermatophagoides farinae Augments Proinflammatory Mediator Productions and Accessory Function of Alveolar Macrophages: Implications for Allergic Sensitization and Inflammation, The Journal of Immunology, vol.170, issue.1, pp.528-536, 2003.
DOI : 10.4049/jimmunol.170.1.528

R. Fischer, J. R. Mcghee, H. L. Vu, T. P. Atkinson, R. J. Jackson et al., Oral and Nasal Sensitization Promote Distinct Immune Responses and Lung Reactivity in a Mouse Model of Peanut Allergy, The American Journal of Pathology, vol.167, issue.6, 2005.
DOI : 10.1016/S0002-9440(10)61246-1

R. Fischer, J. R. Mcghee, H. L. Vu, T. P. Atkinson, R. J. Jackson et al., Distinct immune responses to oral ans nasal peanut. International Proceedings Division. Collection of Free Papers presented at the 12th Int Therapeutic manipulation of the immune system: enhancement of innate and adaptive mucosal immunity, Congress of Immunology and 4th annual Conference of, pp.1965-72, 2003.

P. Boyaka, A. Tafaro, R. Fischer, S. Leppla, K. Fujihashi et al., Effective Mucosal Immunity to Anthrax: Neutralizing Antibodies and Th Cell Responses Following Nasal Immunization with Protective Antigen, The Journal of Immunology, vol.170, issue.11, pp.5636-5679, 2003.
DOI : 10.4049/jimmunol.170.11.5636

R. Fischer, J. R. Mcghee, H. L. Vu, T. P. Atkinson, R. J. Jackson et al., Oral and Nasal Sensitization Promote Distinct Immune Responses and Lung Reactivity in a Mouse Model of Peanut Allergy, The American Journal of Pathology, vol.167, issue.6, 2005.
DOI : 10.1016/S0002-9440(10)61246-1

. Aai-)-meeting, . Denver, M. R. Colorado, J. R. Fischer, H. L. Mcghee et al., Mucosal routes of sensitization influence the immune response in a mouse model of peanut-induced asthma, Communications orales International Congress of Mucosal Immunology Daniel Tomé, and Prosper N. Boyaka. Mucosal routes of peanut sensitization influence lung inflammatory responses to

J. R. Fischer, H. L. Mcghee, T. P. Vu, R. J. Atkinson, D. Jackson et al., A mouse model for investigation of primary and cross-reactive allergic reactions to legumes, Society of Mucosal Immunology (SMI) meeting, 2002.

R. 1. Sicherer, S. Munoz-furlong, A. Sampson, and H. , Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey, Journal of Allergy and Clinical Immunology, vol.112, issue.6, pp.1203-1207, 2003.
DOI : 10.1016/S0091-6749(03)02026-8

J. Bernhisel-broadbent and H. Sampson, Cross-allergenicity in the legume botanical family in children with food hypersensitivity, Journal of Allergy and Clinical Immunology, vol.83, issue.2, pp.435-440, 1989.
DOI : 10.1016/0091-6749(89)90130-9

S. Hefle, R. Lemanske, . Jr, and R. Bush, Adverse reaction to lupine-fortified pasta, Journal of Allergy and Clinical Immunology, vol.94, issue.2, pp.167-172, 1994.
DOI : 10.1053/ai.1994.v94.a54942

D. Moneret-vautrin, L. Guerin, G. Kanny, J. Flabbee, S. Fremont et al., Cross-allergenicity of peanut and lupine: The risk of lupine allergy in patients allergic to peanuts, Journal of Allergy and Clinical Immunology, vol.104, issue.4, pp.883-888, 1999.
DOI : 10.1016/S0091-6749(99)70303-9

S. Sicherer, A. Burks, and H. Sampson, Clinical Features of Acute Allergic Reactions to Peanut and Tree Nuts in Children, PEDIATRICS, vol.102, issue.1, p.6, 1998.
DOI : 10.1542/peds.102.1.e6

S. Sicherer, T. Furlong, J. Desimone, and H. Sampson, Self-reported allergic reactions to peanut on commercial airliners?????????, Journal of Allergy and Clinical Immunology, vol.104, issue.1, pp.186-189, 1999.
DOI : 10.1016/S0091-6749(99)70133-8

R. Rayman, Peanut allergy in-flight, Aviat Space Environ Med, vol.73, pp.501-502, 2002.

G. Roberts, N. Golder, and G. Lack, Bronchial challenges with aerosolized food in asthmatic, food-allergic children, Allergy, vol.16, issue.8, pp.713-717, 2002.
DOI : 10.1046/j.1365-2222.2000.00864.x

J. Crespo, C. Pascual, A. Vallecillo, and M. Esteban, Sensitization to Inhalant Allergens in Children Diagnosed with Food Hypersensitivity, Allergy and Asthma Proceedings, vol.16, issue.2, pp.89-92, 1995.
DOI : 10.2500/108854195778771381

N. Eriksson, H. Formgren, and E. Svenonius, Food Hypersensitivity in Patients with Pollen Allergy, Allergy, vol.34, issue.6, pp.437-443, 1982.
DOI : 10.1111/j.1600-0536.1977.tb03603.x

C. Ortolani, E. Pastorello, L. Farioli, M. Ispano, V. Pravettoni et al., IgE-mediated allergy from vegetable allergens, Ann Allergy, vol.71, pp.470-476, 1993.

E. Enrique, A. Cistero-bahima, B. Bartolome, R. Alonso, S. Miguel-moncin et al., Platanus acerifolia pollinosis and food allergy, Allergy, vol.57, issue.4, pp.351-356, 2002.
DOI : 10.1067/mai.2001.113864

S. Vieths, S. Scheurer, and B. Ballmer-weber, Current Understanding of Cross-Reactivity of Food Allergens and Pollen, Annals of the New York Academy of Sciences, vol.103, issue.1, pp.47-68, 2002.
DOI : 10.1111/j.1749-6632.2002.tb04132.x

M. Van-der-veen, R. Van-ree, R. Aalberse, J. Akkerdaas, S. Koppelman et al., Poor biologic activity of cross-reactive IgE directed to carbohydrate determinants of glycoproteins, Journal of Allergy and Clinical Immunology, vol.100, issue.3, pp.327-334, 1997.
DOI : 10.1016/S0091-6749(97)70245-8

R. Asero, G. Mistrello, D. Roncarolo, S. Amato, G. Caldironi et al., Immunological cross-reactivity between lipid transfer proteins from botanically unrelated plant-derived foods: a clinical study, Allergy, vol.87, issue.10, pp.900-906, 2002.
DOI : 10.1105/tpc.3.9.907

M. De-martino, E. Novembre, G. Cozza, A. De-marco, P. Bonazza et al., Sensitivity to tomato and peanut allergens in children monosensitized to grass pollen, Allergy, vol.107, issue.3, pp.206-213, 1988.
DOI : 10.1111/j.1398-9995.1988.tb00420.x

H. Kiyono and S. Fukuyama, Nalt- versus peyer's-patch-mediated mucosal immunity, Nature Reviews Immunology, vol.213, issue.9, pp.699-710, 2004.
DOI : 10.1016/S0140-6736(04)16501-X

B. Bochner, B. Undem, and L. Lichtenstein, Immunological Aspects of Allergic Asthma, Annual Review of Immunology, vol.12, issue.1, pp.295-335, 1994.
DOI : 10.1146/annurev.iy.12.040194.001455

J. Renauld, New insights into the role of cytokines in asthma, Journal of Clinical Pathology, vol.54, issue.8, pp.577-589, 2001.
DOI : 10.1136/jcp.54.8.577

M. Macedo-soares, D. Itami, C. Lima, A. Perini, E. Faquim-mauro et al., Lung eosinophilic inflammation and airway hyperreactivity are enhanced by murine anaphylactic, but not nonanaphylactic, IgG1 antibodies, Journal of Allergy and Clinical Immunology, vol.114, issue.1, pp.97-104, 2004.
DOI : 10.1016/j.jaci.2004.03.033

M. Jenmalm, B. Bjorksten, C. Macaubas, B. Holt, T. Smallacombe et al., Allergen-induced cytokine secretion in relation to atopic symptoms and immunoglobulin E and immunoglobulin G subclass antibody responses, Pediatric Allergy and Immunology, vol.160, issue.3, pp.168-177, 1999.
DOI : 10.1034/j.1399-3038.1999.00015.x

T. Huang, P. Macary, P. Eynott, A. Moussavi, K. Daniel et al., Allergen-Specific Th1 Cells Counteract Efferent Th2 Cell-Dependent Bronchial Hyperresponsiveness and Eosinophilic Inflammation Partly Via IFN-??, The Journal of Immunology, vol.166, issue.1, pp.207-217, 2001.
DOI : 10.4049/jimmunol.166.1.207

G. Hansen, G. Berry, R. Dekruyff, and D. Umetsu, Allergen-specific Th1 cells fail to counterbalance Th2 cell???induced airway hyperreactivity but cause severe airway inflammation, Journal of Clinical Investigation, vol.103, issue.2, pp.175-183, 1999.
DOI : 10.1172/JCI5155

D. Randolph, C. Carruthers, S. Szabo, K. Murphy, and D. Chaplin, Modulation of airway inflammation by passive transfer of allergenspecific Th1 and Th2 cells in a mouse model of asthma, J Immunol, vol.162, pp.2375-2383, 1999.

D. Randolph, R. Stephens, C. Carruthers, and D. Chaplin, Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation, Journal of Clinical Investigation, vol.104, issue.8, pp.1021-1029, 1999.
DOI : 10.1172/JCI7631

A. Takaoka, Y. Tanaka, T. Tsuji, T. Jinushi, A. Hoshino et al., A Critical Role for Mouse CXC Chemokine(s) in Pulmonary Neutrophilia During Th Type 1-Dependent Airway Inflammation, The Journal of Immunology, vol.167, issue.4, pp.2349-2353, 2001.
DOI : 10.4049/jimmunol.167.4.2349

S. Teuber, D. Val, G. Morigasaki, S. Jung, H. Eisele et al., The atopic dog as a model of peanut and tree nut food allergy, Journal of Allergy and Clinical Immunology, vol.110, issue.6, pp.921-927, 2002.
DOI : 10.1067/mai.2002.130056

R. Helm, G. Furuta, J. Stanley, J. Ye, G. Cockrell et al., A neonatal swine model for peanut allergy, Journal of Allergy and Clinical Immunology, vol.109, issue.1, pp.136-142, 2002.
DOI : 10.1067/mai.2002.120551

L. Pons, U. Ponnappan, R. Hall, P. Simpson, G. Cockrell et al., Soy immunotherapy for peanut-allergic mice: Modulation of the peanut-allergic response, Journal of Allergy and Clinical Immunology, vol.114, issue.4, pp.915-921, 2004.
DOI : 10.1016/j.jaci.2004.06.049

M. Bashir, P. Andersen, I. Fuss, H. Shi, and C. Nagler-anderson, An Enteric Helminth Infection Protects Against an Allergic Response to Dietary Antigen, The Journal of Immunology, vol.169, issue.6, pp.3284-3292, 2002.
DOI : 10.4049/jimmunol.169.6.3284

X. Li, K. Srivastava, J. Huleatt, K. Bottomly, A. Burks et al., Engineered Recombinant Peanut Protein and Heat-Killed Listeria monocytogenes Coadministration Protects Against Peanut-Induced Anaphylaxis in a Murine Model, The Journal of Immunology, vol.170, issue.6, pp.3289-3295, 2003.
DOI : 10.4049/jimmunol.170.6.3289

F. Van-wijk, S. Hartgring, S. Koppelman, R. Pieters, and L. Knippels, Mixed antibody and T cell responses to peanut and the peanut allergens Ara h 1, Ara h 2, Ara h 3 and Ara h 6 in an oral sensitization model, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.62, issue.15, pp.1422-1428, 2004.
DOI : 10.1046/j.1365-2222.1998.00301.x

A. Visweswaraiah, L. Novotny, E. Hjemdahl-monsen, L. Bakaletz, and Y. Thanavala, Tracking the tissue distribution of marker dye following intranasal delivery in mice and chinchillas: a multifactorial analysis of parameters affecting nasal retention, Vaccine, vol.20, issue.25-26, pp.3209-3220, 2002.
DOI : 10.1016/S0264-410X(02)00247-5

M. Marinaro, H. Staats, T. Hiroi, R. Jackson, M. Coste et al., Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4, J Immunol, vol.155, pp.4621-4629, 1995.

S. Lehrer, R. Reish, J. Fernandes, P. Gaudry, G. Dai et al., Enhancement of murine IgE antibody detection by IgG removal, Journal of Immunological Methods, vol.284, issue.1-2, pp.1-6, 2004.
DOI : 10.1016/j.jim.2003.08.017

E. Hamelmann, J. Schwarze, K. Takeda, A. Oshiba, G. Larsen et al., Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography, American Journal of Respiratory and Critical Care Medicine, vol.156, issue.3, pp.766-775, 1997.
DOI : 10.1164/ajrccm.156.3.9606031

M. Strath, D. Warren, and C. Sanderson, Detection of eosinophils using an eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors, Journal of Immunological Methods, vol.83, issue.2, pp.209-215, 1985.
DOI : 10.1016/0022-1759(85)90242-X

M. Devey, K. Anderson, R. Coombs, M. Henschel, and M. Coates, The modified anaphylaxis hypothesis for cot death: anaphylactic sensitization in guinea-pigs fed cow's milk, Clin Exp Immunol, vol.26, pp.542-548, 1976.

L. Knippels and A. Penninks, Assessment of Protein Allergenicity, Annals of the New York Academy of Sciences, vol.157, issue.S, pp.151-161, 2002.
DOI : 10.1111/j.1749-6632.2002.tb04140.x

R. Ermel, M. Kock, S. Griffey, G. Reinhart, and O. Frick, The atopic dog: a model for food allergy, Lab Anim Sci, vol.47, pp.40-49, 1997.

N. Childers, K. Miller, G. Tong, J. Llarena, T. Greenway et al., Adjuvant Activity of Monophosphoryl Lipid A for Nasal and Oral Immunization with Soluble or Liposome-Associated Antigen, Infection and Immunity, vol.68, issue.10, pp.5509-5516, 2000.
DOI : 10.1128/IAI.68.10.5509-5516.2000

X. Li, D. Serebrisky, S. Lee, C. Huang, L. Bardina et al., A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses, Journal of Allergy and Clinical Immunology, vol.106, issue.1, pp.150-158, 2000.
DOI : 10.1067/mai.2000.107395

T. Perry, M. Conover-walker, A. Pomes, M. Chapman, and R. Wood, Distribution of peanut allergen in the environment, Journal of Allergy and Clinical Immunology, vol.113, issue.5, pp.973-976, 2004.
DOI : 10.1016/j.jaci.2004.02.035

E. Butcher and L. Picker, Lymphocyte Homing and Homeostasis, Science, vol.272, issue.5258, pp.60-66, 1996.
DOI : 10.1126/science.272.5258.60

D. Snider, The Mucosal Adjuvant Activities of ADP-Ribosylating Bacterial Enterotoxins, Critical Reviews??? in Immunology, vol.15, issue.3-4, pp.317-348, 1995.
DOI : 10.1615/CritRevImmunol.v15.i3-4.70

J. Simecka, R. Jackson, H. Kiyono, and J. Mcghee, Mucosally Induced Immunoglobulin E-Associated Inflammation in the Respiratory Tract, Infection and Immunity, vol.68, issue.2, pp.672-679, 2000.
DOI : 10.1128/IAI.68.2.672-679.2000

A. Rudin, E. Johansson, C. Bergquist, and J. Holmgren, Differential kinetics and distribution of antibodies in serum and nasal and vaginal secretions after nasal and oral vaccination of humans, Infect Immun, vol.66, pp.3390-3396, 1998.

A. Rudin, G. Riise, and J. Holmgren, Antibody responses in the lower respiratory tract and male urogenital tract in humans after nasal and oral vaccination with cholera toxin B subunit, Infect Immun, vol.67, pp.2884-2890, 1999.

G. Douce, M. Giuliani, V. Giannelli, M. Pizza, R. Rappuoli et al., Mucosal immunogenicity of genetically detoxified derivatives of heat labile toxin from Escherichia coli, Vaccine, vol.16, issue.11-12, pp.1065-1073, 1998.
DOI : 10.1016/S0264-410X(98)80100-X

D. Auci, S. Chice, C. Heusser, T. Athanassiades, and H. Durkin, Origin and fate of IgE-bearing lymphocytes. II. Gut-associated lymphoid tissue as sites of first appearance of IgE-bearing B lymphocytes and hapten-specific IgE antibody-forming cells in mice immunized with benzylpenicilloyl-keyhole limpet hemocyanin by various routes: relation to asialo GM1 ganglioside cells and IgE/CD23 immune complexes, J Immunol, vol.149, pp.2241-2248, 1992.

H. Durkin, H. Bazin, and B. Waksman, Origin and fate of IgE-bearing lymphocytes. I. Peyer's patches as differentiation site of cells. Simultaneously bearing IgA and IgE, Journal of Experimental Medicine, vol.154, issue.3, pp.640-648, 1981.
DOI : 10.1084/jem.154.3.640

P. Boyaka, M. Ohmura, K. Fujihashi, T. Koga, M. Yamamoto et al., Chimeras of Labile Toxin One and Cholera Toxin Retain Mucosal Adjuvanticity and Direct Th Cell Subsets Via Their B Subunit, The Journal of Immunology, vol.170, issue.1, pp.454-462, 2003.
DOI : 10.4049/jimmunol.170.1.454

S. Yamamoto, H. Kiyono, M. Yamamoto, K. Imaoka, K. Fujihashi et al., A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity, Proceedings of the National Academy of Sciences, vol.94, issue.10, pp.5267-5272, 1997.
DOI : 10.1073/pnas.94.10.5267

M. Kweon, M. Yamamoto, F. Watanabe, S. Tamura, V. Ginkel et al., A Nontoxic Chimeric Enterotoxin Adjuvant Induces Protective Immunity in Both Mucosal and Systemic Compartments with Reduced IgE Antibodies, The Journal of Infectious Diseases, vol.186, issue.9, pp.1261-1269, 2002.
DOI : 10.1086/344526

Y. Riffo-vasquez and D. Spina, Role of cytokines and chemokines in bronchial hyperresponsiveness and airway inflammation, Pharmacology & Therapeutics, vol.94, issue.3, pp.185-211, 2002.
DOI : 10.1016/S0163-7258(02)00217-6

F. Finkelman, I. Katona, J. Urban, . Jr, J. Holmes et al., IL-4 is required to generate and sustain in vivo IgE responses, J Immunol, vol.141, pp.2335-2341, 1988.

R. Kuhn, K. Rajewsky, and W. Muller, Generation and analysis of interleukin-4 deficient mice, Science, vol.254, issue.5032, pp.707-710, 1991.
DOI : 10.1126/science.1948049

W. Paul, Interleukin-4, Blood, vol.77, pp.1859-1870, 1991.
DOI : 10.1016/B0-12-341103-3/00154-6

J. De-vries, The role of IL-13 and its receptor in allergy and inflammatory responses, Journal of Allergy and Clinical Immunology, vol.102, issue.2, pp.165-169, 1998.
DOI : 10.1016/S0091-6749(98)70080-6

F. Finkelman, I. Katona, T. Mosmann, and R. Coffman, IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses, J Immunol, vol.140, pp.1022-1027, 1988.

A. Mishra, S. Hogan, and E. Brandt, Rothenberg ME: Peyer's patch eosinophils: identification, characterization, and regulation by mucosal allergen exposure, interleukin-5, and eotaxin, Blood, vol.96, pp.1538-1544, 2000.

S. Hogan, A. Mishra, E. Brandt, M. Royalty, S. Pope et al., A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation, Nature Immunology, vol.185, issue.4, pp.353-360, 2001.
DOI : 10.1038/86365

P. Foster, S. Hogan, A. Ramsay, K. Matthaei, and I. Young, Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model, Journal of Experimental Medicine, vol.183, issue.1, pp.195-201, 1996.
DOI : 10.1084/jem.183.1.195

K. Chung and P. Barnes, Cytokines in asthma, Thorax, vol.54, issue.9, pp.825-857, 1999.
DOI : 10.1136/thx.54.9.825

A. Linden, Role of Interleukin-17 and the Neutrophil in Asthma, International Archives of Allergy and Immunology, vol.126, issue.3, pp.179-184, 2001.
DOI : 10.1159/000049511

P. Hellings, A. Kasran, Z. Liu, P. Vandekerckhove, A. Wuyts et al., Interleukin-17 Orchestrates the Granulocyte Influx into Airways after Allergen Inhalation in a Mouse Model of Allergic Asthma, American Journal of Respiratory Cell and Molecular Biology, vol.28, issue.1, pp.42-50, 2003.
DOI : 10.1165/rcmb.4832

J. Bates, C. Irvin, V. Brusasco, J. Drazen, J. Fredberg et al., The Use and Misuse of Penh in Animal Models of Lung Disease, American Journal of Respiratory Cell and Molecular Biology, vol.31, issue.3, pp.373-374, 2004.
DOI : 10.1165/ajrcmb.31.3.1

A. Adler, G. Cieslewicz, and C. Irvin, Unrestrained plethysmography is an unreliable measure of airway responsiveness in BALB/c and C57BL/6 mice, Journal of Applied Physiology, vol.97, issue.1, pp.286-292, 2004.
DOI : 10.1152/japplphysiol.00821.2003

J. Schwarze, E. Hamelmann, E. Gelfand, A. Adler, G. Cieslewicz et al., Barometric whole body plethysmography in mice, Journal of Applied Physiology, vol.98, issue.5, pp.1955-1957, 2005.
DOI : 10.1152/japplphysiol.01279.2004

S. Eum, S. Haile, J. Lefort, M. Huerre, and B. Vargaftig, Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness., Proceedings of the National Academy of Sciences, vol.92, issue.26, pp.12290-12294, 1995.
DOI : 10.1073/pnas.92.26.12290

A. Coyle, K. Wagner, C. Bertrand, S. Tsuyuki, J. Bews et al., Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody, Journal of Experimental Medicine, vol.183, issue.4, pp.1303-1310, 1996.
DOI : 10.1084/jem.183.4.1303

S. Sehra, G. Pynaert, K. Tournoy, A. Haegeman, P. Matthys et al., Airway IgG Counteracts Specific and Bystander Allergen-Triggered Pulmonary Inflammation by a Mechanism Dependent on Fc??R and IFN-??, The Journal of Immunology, vol.171, issue.4, pp.2080-2089, 2003.
DOI : 10.4049/jimmunol.171.4.2080

S. Anticevich, J. Hughes, J. Black, and C. Armour, Induction of hyperresponsiveness in human airway tissue by neutrophils - mechanism of action, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.26, issue.5, pp.549-556, 1996.
DOI : 10.1046/j.1365-2222.1996.d01-341.x

J. Douwes, P. Gibson, J. Pekkanen, and N. Pearce, Non-eosinophilic asthma: importance and possible mechanisms, Thorax, vol.57, issue.7, pp.643-648, 2002.
DOI : 10.1136/thorax.57.7.643

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1746367

A. Jatakanon, C. Uasuf, W. Maziak, S. Lim, K. Chung et al., Neutrophilic Inflammation in Severe Persistent Asthma, American Journal of Respiratory and Critical Care Medicine, vol.160, issue.5, pp.1532-1539, 1999.
DOI : 10.1164/ajrccm.160.5.9806170

E. Forbes, V. Smart, D. Aprile, A. Henry, P. Yang et al., T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice, Gastroenterology, vol.127, issue.1, pp.105-118, 2004.
DOI : 10.1053/j.gastro.2004.03.057

C. Chen, C. Lee, Y. Liu, J. Wang, H. Lei et al., House Dust Mite Dermatophagoides farinae Augments Proinflammatory Mediator Productions and Accessory Function of Alveolar Macrophages: Implications for Allergic Sensitization and Inflammation, The Journal of Immunology, vol.170, issue.1, pp.528-536, 2003.
DOI : 10.4049/jimmunol.170.1.528

S. Wenzel, L. Schwartz, E. Langmack, J. Halliday, J. Trudeau et al., Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics, American Journal of Respiratory and Critical Care Medicine, vol.160, issue.3, pp.1001-1008, 1999.
DOI : 10.1164/ajrccm.160.3.9812110

J. Douwes, P. Gibson, J. Pekkanen, and N. Pearce, Non-eosinophilic asthma: importance and possible mechanisms, Thorax, vol.57, issue.7, pp.643-648, 2002.
DOI : 10.1136/thorax.57.7.643

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1746367

A. Linden, Role of Interleukin-17 and the Neutrophil in Asthma, International Archives of Allergy and Immunology, vol.126, issue.3, pp.179-184, 2001.
DOI : 10.1159/000049511

J. Kips, G. Anderson, J. Fredberg, U. Herz, M. Inman et al., Murine models of asthma, Murine models of asthma, pp.374-382, 2003.
DOI : 10.1183/09031936.03.00026403

U. Herz, H. Renz, and U. Wiedermann, Animal models of type I allergy using recombinant allergens, Methods, vol.32, issue.3, pp.271-280, 2004.
DOI : 10.1016/j.ymeth.2003.08.013

D. Randolph, R. Stephens, C. Carruthers, and D. Chaplin, Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation, Journal of Clinical Investigation, vol.104, issue.8, pp.1021-1029, 1999.
DOI : 10.1172/JCI7631

A. Takaoka, Y. Tanaka, T. Tsuji, T. Jinushi, A. Hoshino et al., A Critical Role for Mouse CXC Chemokine(s) in Pulmonary Neutrophilia During Th Type 1-Dependent Airway Inflammation, The Journal of Immunology, vol.167, issue.4, pp.2349-2353, 2001.
DOI : 10.4049/jimmunol.167.4.2349

T. Huang, P. Macary, P. Eynott, A. Moussavi, K. Daniel et al., Allergen-Specific Th1 Cells Counteract Efferent Th2 Cell-Dependent Bronchial Hyperresponsiveness and Eosinophilic Inflammation Partly Via IFN-??, The Journal of Immunology, vol.166, issue.1, pp.207-217, 2001.
DOI : 10.4049/jimmunol.166.1.207

N. Krug, J. Madden, A. Redington, P. Lackie, R. Djukanovic et al., T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma., American Journal of Respiratory Cell and Molecular Biology, vol.14, issue.4, pp.319-326, 1996.
DOI : 10.1165/ajrcmb.14.4.8600935

K. Bodey, A. Semper, A. Redington, J. Madden, L. Teran et al., Cytokine profiles of BAL T cells and T-cell clones obtained from human asthmatic airways after local allergen challenge, Allergy, vol.103, issue.10, pp.1083-1093, 1999.
DOI : 10.1034/j.1398-9995.1999.00889.x

J. Bernhisel-broadbent and H. Sampson, Cross-allergenicity in the legume botanical family in children with food hypersensitivity, Journal of Allergy and Clinical Immunology, vol.83, issue.2, pp.435-440, 1989.
DOI : 10.1016/0091-6749(89)90130-9

A. Visweswaraiah, L. Novotny, E. Hjemdahl-monsen, L. Bakaletz, and Y. Thanavala, Tracking the tissue distribution of marker dye following intranasal delivery in mice and chinchillas: a multifactorial analysis of parameters affecting nasal retention, Vaccine, vol.20, issue.25-26, pp.3209-3220, 2002.
DOI : 10.1016/S0264-410X(02)00247-5

M. Marinaro, H. Staats, T. Hiroi, R. Jackson, M. Coste et al., Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL- 4, J Immunol, vol.155, pp.4621-4629, 1995.

S. Lehrer, R. Reish, J. Fernandes, P. Gaudry, G. Dai et al., Enhancement of murine IgE antibody detection by IgG removal, Journal of Immunological Methods, vol.284, issue.1-2, pp.1-6, 2004.
DOI : 10.1016/j.jim.2003.08.017

M. Strath, D. Warren, and C. Sanderson, Detection of eosinophils using an eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors, Journal of Immunological Methods, vol.83, issue.2, pp.209-215, 1985.
DOI : 10.1016/0022-1759(85)90242-X

S. Anticevich, J. Hughes, J. Black, and C. Armour, Induction of hyperresponsiveness in human airway tissue by neutrophils - mechanism of action, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.26, issue.5, pp.549-556, 1996.
DOI : 10.1046/j.1365-2222.1996.d01-341.x

Y. Zhang, W. Lamm, R. Albert, E. Chi, W. Henderson et al., Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response., American Journal of Respiratory and Critical Care Medicine, vol.155, issue.2, pp.661-669, 1997.
DOI : 10.1164/ajrccm.155.2.9032210

K. Takeda, A. Haczku, J. Lee, C. Irvin, and E. Gelfand, Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung, Am J Physiol Lung Cell Mol Physiol, vol.281, pp.394-402, 2001.

C. Elson and W. Ealding, Genetic control of the murine immune response to cholera toxin, J Immunol, vol.135, pp.930-932, 1985.

C. Elson, Cholera Toxin as a Mucosal Adjuvant, Infect Immun, vol.60, pp.2874-2879, 1992.
DOI : 10.1016/B978-012410580-5/50005-4

T. Thepen, K. Hoeben, J. Breve, and G. Kraal, Alveolar macrophages down-regulate local pulmonary immune responses against intratracheally administered T-cell-dependent, but not T-cell-independent antigens, pp.60-64, 1992.

F. Finkelman, I. Katona, J. Urban, J. Holmes, J. Ohara et al., IL-4 is required to generate and sustain in vivo IgE responses, J Immunol, vol.141, pp.2335-2341, 1988.

S. Bergstedt-lindqvist, H. Moon, U. Persson, G. Moller, C. Heusser et al., Interleukin 4 instructs uncommitted B lymphocytes to switch to IgGl and IgE, European Journal of Immunology, vol.139, issue.7, pp.1073-1077, 1988.
DOI : 10.1002/eji.1830180716

R. Kuhn, K. Rajewsky, and W. Muller, Generation and analysis of interleukin-4 deficient mice, Science, vol.254, issue.5032, pp.707-710, 1991.
DOI : 10.1126/science.1948049

N. Okahashi, M. Yamamoto, J. Vancott, S. Chatfield, M. Roberts et al., Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses, Infect Immun, vol.64, pp.1516-1525, 1996.

A. Metwali, D. Elliott, A. Blum, J. Li, M. Sandor et al., The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice, J Immunol, vol.157, pp.4546-4553, 1996.

J. Gauldie and E. Gelfand, Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice, Am J Respir Cell Mol Biol, vol.23, pp.327-334, 2000.

C. Herrick, H. Macleod, E. Glusac, R. Tigelaar, and K. Bottomly, Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4, Journal of Clinical Investigation, vol.105, issue.6, pp.765-775, 2000.
DOI : 10.1172/JCI8624

M. Vajdy, M. Kosco-vilbois, M. Kopf, G. Kohler, and N. Lycke, Impaired mucosal immune responses in interleukin 4-targeted mice, Journal of Experimental Medicine, vol.181, issue.1, pp.41-53, 1995.
DOI : 10.1084/jem.181.1.41

G. Mckenzie, P. Fallon, C. Emson, R. Grencis, and A. Mckenzie, Simultaneous Disruption of Interleukin (IL)-4 and IL-13 Defines Individual Roles in T Helper Cell Type 2???mediated Responses, The Journal of Experimental Medicine, vol.154, issue.10, pp.1565-1572, 1999.
DOI : 10.1126/science.282.5397.2261

G. Brusselle, J. Kips, J. Tavernier, J. Van-der-heyden, C. Cuvelier et al., Attenuation of allergic airway inflammation in IL-4 deficient mice, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.257, issue.1, pp.73-80, 1994.
DOI : 10.1016/0092-8674(90)90011-3

N. Lukacs, R. Strieter, S. Chensue, and S. Kunkel, Interleukin-4-dependent pulmonary eosinophil infiltration in a murine model of asthma., American Journal of Respiratory Cell and Molecular Biology, vol.10, issue.5, pp.526-532, 1994.
DOI : 10.1165/ajrcmb.10.5.8179915

A. Coyle, L. Gros, G. Bertrand, C. Tsuyuki, S. Heusser et al., Interleukin-4 is required for the induction of lung Th2 mucosal immunity., American Journal of Respiratory Cell and Molecular Biology, vol.13, issue.1, pp.54-59, 1995.
DOI : 10.1165/ajrcmb.13.1.7598937

S. Hogan, A. Mould, H. Kikutani, A. Ramsay, and P. Foster, Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins., Journal of Clinical Investigation, vol.99, issue.6, pp.1329-1339, 1997.
DOI : 10.1172/JCI119292

M. Okano, A. Satoskar, M. Abe, D. Harn, J. Okano et al., Interleukin-4-independent production of Th2 cytokines by nasal lymphocytes and nasal eosinophilia in murine allergic rhinitis, Allergy, vol.26, issue.8, pp.723-731, 2000.
DOI : 10.1034/j.1398-9995.2000.00429.x

D. Webb, A. Mckenzie, A. Koskinen, M. Yang, J. Mattes et al., Integrated Signals Between IL-13, IL-4, and IL-5 Regulate Airways Hyperreactivity, The Journal of Immunology, vol.165, issue.1, pp.108-113, 2000.
DOI : 10.4049/jimmunol.165.1.108

D. Walter, J. Mcintire, G. Berry, A. Mckenzie, D. Donaldson et al., Critical Role for IL-13 in the Development of Allergen-Induced Airway Hyperreactivity, The Journal of Immunology, vol.167, issue.8, pp.4668-4675, 2001.
DOI : 10.4049/jimmunol.167.8.4668

S. Zurawski, P. Chomarat, O. Djossou, C. Bidaud, A. Mckenzie et al., The Primary Binding Subunit of the Human Interleukin-4 Receptor Is Also a Component of the Interleukin-13 Receptor, Journal of Biological Chemistry, vol.270, issue.23, pp.13869-13878, 1995.
DOI : 10.1074/jbc.270.23.13869

J. Lin, T. Migone, M. Tsang, M. Friedmann, J. Weatherbee et al., The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15, IL-13, and IL-15, pp.331-339, 1995.
DOI : 10.1016/1074-7613(95)90141-8

S. Eum, S. Haile, J. Lefort, M. Huerre, and B. Vargaftig, Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness., Proceedings of the National Academy of Sciences, vol.92, issue.26, pp.12290-12294, 1995.
DOI : 10.1073/pnas.92.26.12290

A. Coyle, K. Wagner, C. Bertrand, S. Tsuyuki, J. Bews et al., Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and

S. Wolf, P. Temple, M. Kobayashi, D. Young, M. Dicig et al., Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells, J Immunol, vol.146, pp.3074-3081, 1991.

L. Zhao, A. Linden, M. Sjostrand, Z. Cui, J. Lotvall et al., IL-12 regulates bone marrow eosinophilia and airway eotaxin levels induced by airway allergen exposure, Allergy, vol.21, issue.8, pp.749-756, 2000.
DOI : 10.1034/j.1398-9995.2000.00583.x

R. Manetti, P. Parronchi, M. Giudizi, M. Piccinni, E. Maggi et al., Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells, Journal of Experimental Medicine, vol.177, issue.4, pp.1199-1204, 1993.
DOI : 10.1084/jem.177.4.1199

S. Wang, Y. Fan, X. Han, J. Yang, L. Bilenki et al., IL-12-Dependent Vascular Cell Adhesion Molecule-1 Expression Contributes to Airway Eosinophilic Inflammation in a Mouse Model of Asthma-Like Reaction, The Journal of Immunology, vol.166, issue.4, pp.2741-2749, 2001.
DOI : 10.4049/jimmunol.166.4.2741

R. Seder, R. Gazzinelli, A. Sher, and W. Paul, Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming., Proceedings of the National Academy of Sciences, vol.90, issue.21, pp.10188-10192, 1993.
DOI : 10.1073/pnas.90.21.10188

H. Okamura, H. Tsutsi, T. Komatsu, M. Yutsudo, A. Hakura et al., Cloning of a new cytokine that induces IFN-?? production by T cells, Nature, vol.378, issue.6552, pp.88-91, 1995.
DOI : 10.1038/378088a0

G. Hansen, G. Berry, R. Dekruyff, and D. Umetsu, Allergen-specific Th1 cells fail to counterbalance Th2 cell???induced airway hyperreactivity but cause severe airway inflammation, Journal of Clinical Investigation, vol.103, issue.2, pp.175-183, 1999.
DOI : 10.1172/JCI5155

D. Randolph, C. Carruthers, S. Szabo, K. Murphy, and D. Chaplin, Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma, J Immunol, vol.162, pp.2375-2383, 1999.

F. Heinzel, A. Hujer, F. Ahmed, and R. Rerko, In vivo production and function of IL-12 p40 homodimers, J Immunol, vol.158, pp.4381-4388, 1997.