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Contributions à l'étude de l'influence de l'alimentation sur la régulation du sommeil

Benjamin Guesdon 
Abstract : Interactions between sleep and food intake are well recognized as being complex and multiple. In this context, we decided to study the influence of food intake on sleep regulation through two complementary approachs: in the so-called metabolic approach, we considered the influence of the whole proteino-energetic intake; in the so-called nutraceutical approach, we considered food intake as a natural source of active molecules. In this last approach, we focused on the case of a particular food compound, that is a tryptic peptidic hydrolysate with anxiolytic properties. First, we produced an original model where not only quantitative but also qualitative modulations of sleep stages appear to be induced by specific modulations of the proteino-energetic composition of the diet, in link with specific modulations of whole body metabolism. Secondly, we showed that the peptidic hydrolysate appears to be able to improve sleep in a physiological way in an animal model of stress-induced sleep impairments. These results bring promising clues for a better understanding of sleep regulation and its links with metabolism and stress. Finally, they also encourage further work on the ability of restaurating a functionnal and physiological sleep by developing alternative dietary treatments of sleep troubles. Keywords: proteic and energetic intake, energy and protein metabolism, αs1–casein hydrolysate, stress, sleep, SWS, PS.
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Submitted on : Thursday, September 28, 2006 - 8:00:00 AM
Last modification on : Monday, October 19, 2020 - 10:54:41 AM
Long-term archiving on: : Thursday, September 30, 2010 - 7:33:13 PM


  • HAL Id : pastel-00001931, version 1



Benjamin Guesdon. Contributions à l'étude de l'influence de l'alimentation sur la régulation du sommeil. Life Sciences [q-bio]. INAPG (AgroParisTech), 2006. English. ⟨NNT : 2006INAP0003⟩. ⟨pastel-00001931⟩



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