) par nos collaborateurs de l'hôpital Tenon selon le procédé suivant : les souris ontétéontété anesthésiéesanesthésiéesà l'avertin (0.1 ml/10 g de masse corporelle) injecté par voie intrapéritonéale, puis les mini-pompes osmotiques ontétéontété placées en position sous-cutanée par une incision dorsale. Les animaux ont reçu ainsi une dose de 1 µg d'Ang II·kg ?1 ·min ?1 pendant 28 jours, associéè a une alimentation supplémentée en sel (5 %) Ce protocole a ´ eté appliquéappliquéà la fois aux souris sauvages, n'ayant pas reçu de traitement avec Ang II, a ´ eté gardé comme témoins négatifs. Après 28 jours (J28) l'administration de l'Ang II a ´ eté arrêtée et la moitié des souris a ´ eté sacrifiée afin de caractériser la progression de la fibrose rénale dans les deux groupes de souris, 2004. ,
fluorescéine-5-isothyocianate) pendant 30 minàminà température ambiante ,
Elle permet de révéler l'activité de l'enzyme TG2 dont elle forme un substrat : la TG2établitTG2établit des ponts ?(??glutamyl)lysine entre les protéines de la matrice extracellulaire et la région peptidique Xpress de la protéine recombinée Identification des cellules qui synthétisent le collagène de type I. Pour cela nous avons utilisé des souris transgéniques exprimant la protéine fluorescente eGFP Cette protéine est donc exprimée dans les cellules o` u il y a une synthèse du collagène de type I. Les reins ontétéontété fixés avec de la formaldéhydè a 4 % pendant 24 h puis placés dans du PBSàPBSà 1 % afin de les visualiser plus tard. Les spectres d'´ emission de différents fluorophores exogènes utilisés dans cetté etude sont montrés sur la Fig. 4.22. 4.5 -Conclusion rénale hypertensive induite par AngII soitàsoità d'autres facteurs, et en association avec des techniques complémentaires nous espérons qu'elle permettra le développement de nouvelles approches thérapeutiques, 2001. ,
Drug-induced pulmonary fibrosis, Environmental Health Perspectives, vol.55, pp.25-36, 1984. ,
DOI : 10.1289/ehp.845525
Nonlinear optics in gyrotropic media, JETP Lett, vol.6, pp.137-140, 1967. ,
Molecular biology of the cell, 1994. ,
Idiopathic pulmonary fibrosis : diagnosis and treatment. international consensus treatment. american thoracis society (ATS), and the european respiratory society (ERS), Am. J. Respir. Crit. Care Med, vol.161, pp.646-664, 2000. ,
Nonlinear scanning laser microscopy by third harmonic generation, Applied Physics Letters, vol.70, issue.8, pp.922-924, 1997. ,
DOI : 10.1063/1.118442
Molecular light scattering and optical activity, 1982. ,
DOI : 10.1017/CBO9780511535468
Visualization of mitochondria in cardiomyocytes, Optics Express, vol.13, issue.20, pp.8263-8276, 2005. ,
DOI : 10.1364/OPEX.13.008263.m004
Sum-Frequency Generation in Chiral Liquids near Electronic Resonance, Physical Review Letters, vol.87, issue.11, pp.113001-113003, 2001. ,
DOI : 10.1103/PhysRevLett.87.113001
Single-Photon Counting Multicolor Multiphoton Fluorescence Microscope, Journal of Fluorescence, vol.50, issue.4, pp.41-51, 2005. ,
DOI : 10.1007/s10895-005-0212-z
A second harmonic generation analog of optical rotatory dispersion for the study of chiral monolayers, The Journal of Chemical Physics, vol.101, issue.7, pp.6233-6241, 1994. ,
DOI : 10.1063/1.468378
Three-Dimensional High-Resolution Second-Harmonic Generation Imaging of Endogenous Structural Proteins in Biological Tissues, Biophysical Journal, vol.82, issue.1, pp.493-508, 2002. ,
DOI : 10.1016/S0006-3495(02)75414-3
Disorders of lung matrix remodeling, Journal of Clinical Investigation, vol.113, issue.2, pp.148-157, 2004. ,
DOI : 10.1172/JCI20729
Green's function formulation for third-harmonic generation microscopy, Journal of the Optical Society of America B, vol.19, issue.7, pp.1604-1610, 2002. ,
DOI : 10.1364/JOSAB.19.001604
3-Dimensional imaging of collagen using second harmonic generation, Journal of Structural Biology, vol.141, issue.1, pp.53-62, 2003. ,
DOI : 10.1016/S1047-8477(02)00576-2
Second-harmonic imaging of plant polysaccharides, Journal of Biomedical Optics, vol.10, issue.2, p.24013, 2005. ,
DOI : 10.1117/1.1896005
Structure sensitivity in third-harmonic generation microscopy, Optics Letters, vol.30, issue.16, pp.2134-2136, 2005. ,
DOI : 10.1364/OL.30.002134
Imaging lipid bodies in cells and tissues using third-harmonic generation microscopy, Nature Methods, vol.61, issue.1, pp.47-53, 2006. ,
DOI : 10.1038/nmeth813
Two-photon laser scanning fluorescence microscopy, Science, vol.248, issue.4951, pp.73-76, 1990. ,
DOI : 10.1126/science.2321027
Studies on the chemical nature of elastin fluorescence, Biochimica et Biophysica Acta (BBA) - Protein Structure, vol.625, issue.2, pp.625-248, 1980. ,
DOI : 10.1016/0005-2795(80)90288-3
Uniform polarity microtubule assemblies imaged in native brain tissue by second-harmonic generation microscopy, Proc. Natl. Acad. Sci. USA, pp.100-7081, 2003. ,
Scanning coherent anti-Stokes Raman microscope, Optics Letters, vol.7, issue.8, pp.350-352, 1982. ,
DOI : 10.1364/OL.7.000350
Influence of optical properties on two-photon fluorescence imaging in turbid samples, Applied Optics, vol.39, issue.7, pp.39-1194, 2000. ,
DOI : 10.1364/AO.39.001194
Differential extraction of keratin subunits and filaments from normal human epidermis, The Journal of Cell Biology, vol.110, issue.4, pp.1149-1158, 1990. ,
DOI : 10.1083/jcb.110.4.1149
Cross-Linking in Collagen and Elastin, Annual Review of Biochemistry, vol.53, issue.1, pp.717-748, 1984. ,
DOI : 10.1146/annurev.bi.53.070184.003441
The Masson staining of collagen ? an explanation of an apparent paradox, The Histochemical Journal, vol.1, issue.6, pp.529-546, 1975. ,
DOI : 10.1007/BF01003791
Second-harmonic microscopy of biological tissue, Optics Letters, vol.11, issue.2, pp.94-96, 1986. ,
DOI : 10.1364/OL.11.000094
Connective tissue polarity. Optical second-harmonic microscopy, crossed-beam summation, and small-angle scattering in rat-tail tendon, Biophysical Journal, vol.50, issue.4, pp.693-712, 1986. ,
DOI : 10.1016/S0006-3495(86)83510-X
A Simple Assay and Histochemical Localization of Transglutaminase Activity Using a Derivative of Green Fluorescent Protein as Substrate, Journal of Histochemistry & Cytochemistry, vol.9, issue.2, pp.247-258, 2001. ,
DOI : 10.1006/dbio.1998.9176
Collagens???structure, function, and biosynthesis, Advanced Drug Delivery Reviews, vol.55, issue.12, pp.1531-1546, 2003. ,
DOI : 10.1016/j.addr.2003.08.002
URL : https://ueaeprints.uea.ac.uk/1112/1/2003_Gelse_et_al_Collagens_structure_function_and______biosynthesis.pdf
Nonlinear Optical Properties of Liquids, Physical Review, vol.138, issue.6A, pp.1599-1606, 1965. ,
DOI : 10.1103/PhysRev.138.A1599
A selective method for the quantitative estimation of elastin fibers, Analyt. Quant. Cytol, vol.4, pp.321-325, 1986. ,
Uber elementarakte mit zwei quantensprüngen, Ann. Phys, vol.9, pp.273-294, 1931. ,
Second-harmonic tomography of tissues, Opt. Lett, vol.22, pp.1323-1325, 1997. ,
Polarization Rotation in a Second Harmonic Reflection Experiment from an Isotropic Surface of Chiral Tr??ger Base, The Journal of Physical Chemistry B, vol.107, issue.22, pp.5261-5266, 2003. ,
DOI : 10.1021/jp034216+
Application of classical models of chirality to surface second harmonic generation, The Journal of Chemical Physics, vol.115, issue.14, pp.6707-6715, 2001. ,
DOI : 10.1063/1.1404983
URL : https://hal.archives-ouvertes.fr/hal-00837033
Second harmonic generation imaging of collagen fibrils in cornea and sclera, Optics Express, vol.13, issue.15, pp.13-5791, 2005. ,
DOI : 10.1364/OPEX.13.005791
Second-Order Nonlinear Optical Effects at Surfaces and Interfaces, Nonlinear surface electromagnetic phenomena, pp.353-415, 1991. ,
DOI : 10.1016/B978-0-444-88359-9.50011-9
Spectroscopy of Molecular Monolayers by Resonant Second-Harmonic Generation, Physical Review Letters, vol.48, issue.7, pp.48-478, 1982. ,
DOI : 10.1103/PhysRevLett.48.478
Study of Si(111) Surfaces by Optical Second-Harmonic Generation: Reconstruction and Surface Phase Transformation, Physical Review Letters, vol.54, issue.1, pp.63-66, 1985. ,
DOI : 10.1103/PhysRevLett.54.63
Determination of molecular orientation of monolayer adsorbates by optical second-harmonic generation, Physical Review A, vol.28, issue.3, pp.28-1883, 1983. ,
DOI : 10.1103/PhysRevA.28.1883
Two-Photon Fluorescence Spectroscopy and Microscopy of NAD(P)H and Flavoprotein, Biophysical Journal, vol.82, issue.5, pp.2811-2825, 2002. ,
DOI : 10.1016/S0006-3495(02)75621-X
Type IV collagen : structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis, J. Biol. Chem, vol.268, pp.26033-26036, 1993. ,
Building Collagen Molecules, Fibrils, and Suprafibrillar Structures, Journal of Structural Biology, vol.137, issue.1-2, pp.2-10, 2002. ,
DOI : 10.1006/jsbi.2002.4450
URL : https://hal.archives-ouvertes.fr/hal-00313823
Observation of C-H stretch vibrations of monolayers of molecules optical sum-frequency generation, Chemical Physics Letters, vol.133, issue.3, pp.189-192, 1987. ,
DOI : 10.1016/0009-2614(87)87049-5
Cyclic Green Fluorescent Protein Produced in Vivo Using an Artificially Split PI-PfuI Intein from Pyrococcus furiosus, Journal of Biological Chemistry, vol.276, issue.19, pp.16548-16554, 2001. ,
DOI : 10.1074/jbc.M011639200
Time course of bleomycin-induced lung fibrosis, International Journal of Experimental Pathology, vol.178, issue.S, pp.279-288, 2002. ,
DOI : 10.1046/j.1365-2613.2002.00220.x
Renal injury from angiotensin II-mediated hypertension, Hypertension, vol.19, issue.5, pp.464-474, 1992. ,
DOI : 10.1161/01.HYP.19.5.464
Tissue Transglutaminase and the Progression of Human Renal Scarring, Journal of the American Society of Nephrology, vol.14, issue.8, pp.14-2052, 2003. ,
DOI : 10.1097/01.ASN.0000079614.63463.DD
Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections, The Histochemical Journal, vol.9, issue.4, pp.447-155, 1979. ,
DOI : 10.1007/BF01002772
Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells., Journal of Clinical Investigation, vol.93, issue.6, pp.2431-2437, 1994. ,
DOI : 10.1172/JCI117251
Epithelial-mesenchymal transition and its implications for fibrosis, Journal of Clinical Investigation, vol.112, issue.12, pp.1776-1784, 2003. ,
DOI : 10.1172/JCI200320530
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC297008
Second???harmonic generation from chiral surfaces, The Journal of Chemical Physics, vol.101, issue.9, pp.8193-8199, 1994. ,
DOI : 10.1063/1.468203
Type VII collagen forms an extended network of anchoring fibrils, The Journal of Cell Biology, vol.104, issue.3, 1987. ,
DOI : 10.1083/jcb.104.3.611
High-resolution multiphoton tomography of human skin with subcellular spatial resolution and picosecond time resolution, Journal of Biomedical Optics, vol.8, issue.3, 2003. ,
DOI : 10.1117/1.1577349
Histological Staining as a Measure of Stress in Collagen Fibers, Journal of Biomechanical Engineering, vol.106, issue.2, pp.174-176, 1984. ,
DOI : 10.1115/1.3138476
Water-Soluble Quantum Dots for Multiphoton Fluorescence Imaging in Vivo, Science, vol.300, issue.5624, pp.300-1434, 2003. ,
DOI : 10.1126/science.1083780
Fluorescence microscopy, Nature Methods, vol.176, issue.12, pp.910-919, 2005. ,
DOI : 10.1038/nmeth817
Transglutaminases: crosslinking enzymes with pleiotropic functions, Nature Reviews Molecular Cell Biology, vol.276, issue.2, pp.140-156, 2003. ,
DOI : 10.1038/nrm1014
A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations, Hepatology, vol.24, issue.5, pp.40-1151, 2004. ,
DOI : 10.1002/hep.20427
N2 laser excited autofluorescence spectroscopy of formalin-fixed human breast tissue, Journal of Photochemistry and Photobiology B: Biology, vol.81, issue.1, pp.33-42, 2005. ,
DOI : 10.1016/j.jphotobiol.2005.06.002
Surface second-harmonic generation from chiral materials, Physical Review B, vol.51, issue.3, pp.1425-1434, 1995. ,
DOI : 10.1103/PhysRevB.51.1425
Uniqueness of waveplate measurements in determining the tensor components of second-order surface nonlinearities, Phys. Rev. B, issue.8, pp.55-5021, 1997. ,
Comparison of linearly and circularly polarized probes of second???order optical activity of chiral surfaces, The Journal of Chemical Physics, vol.105, issue.2, pp.767-772, 1996. ,
DOI : 10.1063/1.471886
Multiphoton excitation fluorescence microscopy and spectroscopy of in vivo human skin, Biophysical Journal, vol.72, issue.6, pp.2405-2412, 1997. ,
DOI : 10.1016/S0006-3495(97)78886-6
Second-harmonic generation by focused excitation of inhomogeneously distributed scatterers, Optics Communications, vol.196, issue.1-6, pp.325-330, 0196. ,
DOI : 10.1016/S0030-4018(01)01403-1
Oscillations and hypoxic changes of mitochondrial variables in neurons of the brainstem respiratory centre of mice, The Journal of Physiology, vol.9, issue.1, pp.227-236, 2001. ,
DOI : 10.1111/j.1469-7793.2001.0227b.x
Tubulointerstitial Changes as a Major Determinant in the Progression of Renal Damage, American Journal of Kidney Diseases, vol.20, issue.1, pp.1-17, 1990. ,
DOI : 10.1016/S0272-6386(12)80312-X
Mechanisms of Disease: fibroblasts???a new look at an old problem, Nature Clinical Practice Nephrology, vol.10, issue.2, pp.101-108, 2006. ,
DOI : 10.1038/ncpneph0093
Two-photon microscopy in brain tissue : parameters influencing the imaging depth, J. Neurosci. Methods, pp.111-140, 2001. ,
Chiroptical Effects in the Second Harmonic Signal of Collagens I and IV, Journal of the American Chemical Society, vol.127, issue.29, pp.10314-10322, 2005. ,
DOI : 10.1021/ja0520969
URL : https://hal.archives-ouvertes.fr/hal-00829225
Spectroscopic analysis of keratin endogenous signal for skin multiphoton microscopy, Opt. Express, vol.6667, issue.1617, pp.13-6268, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-00807874
Circular dichroism spectroscopy at interfaces: a surface second harmonic generation study, The Journal of Physical Chemistry, vol.97, issue.7, pp.1383-1388, 1993. ,
DOI : 10.1021/j100109a022
Characterization of the Myosin-Based Source for Second-Harmonic Generation from Muscle Sarcomeres, Biophysical Journal, vol.90, issue.2, pp.693-703, 2006. ,
DOI : 10.1529/biophysj.105.071555
In Vivo NADH Fluorescence Monitoring as an Assay for Cellular Damage in Photodynamic Therapy??, Photochemistry and Photobiology, vol.74, issue.6, pp.74-817, 2001. ,
DOI : 10.1562/0031-8655(2001)0740817IVNFMA2.0.CO2
Variability of Interalveolar Septal Remodeling After Bleomycin Treatment in Mice, Ultrastructural Pathology, vol.201, issue.1, pp.53-64, 2005. ,
DOI : 10.1002/path.1711240407
QUANTITATIVE OPTICAL SPECTROSCOPY FOR TISSUE DIAGNOSIS, Annual Review of Physical Chemistry, vol.47, issue.1, pp.555-606, 1996. ,
DOI : 10.1146/annurev.physchem.47.1.555
Circular dichroism and linear dichroism, 1997. ,
Second-harmonic generation in collagen, J. Chem. Phys, vol.70, pp.1637-1643, 1979. ,
Laminin 5 Binds the NC-1 Domain of Type VII Collagen, The Journal of Cell Biology, vol.260, issue.3, pp.719-728, 1997. ,
DOI : 10.1083/jcb.117.5.1119
URL : https://hal.archives-ouvertes.fr/hal-00314048
Electrical activity alterations induced by chronic absorption of lindane (γ-hexachlorocyclohexane) trace concentrations in adult rat heart, Canadian Journal of Physiology and Pharmacology, vol.83, issue.3, pp.243-251, 2005. ,
DOI : 10.1139/y04-132
URL : https://hal.archives-ouvertes.fr/hal-00829230
Does lindane (gamma-hexachlorocyclohexane) increase the rapid delayed rectifier outward k+ current (ikr) in frog atrial myocytes ?, BMC Pharmacology, vol.2, issue.1, p.15, 2002. ,
DOI : 10.1186/1471-2210-2-15
URL : https://hal.archives-ouvertes.fr/inserm-00123600
Off resonance second order optical activity of isotropic layers of chiral molecules: Observation of electric and magnetic contributions, The Journal of Chemical Physics, vol.108, issue.22, pp.9436-9443, 1998. ,
DOI : 10.1063/1.476394
Nonlinear optical spectroscopy of chiral molecules, Recent Res. Devel. Chem. Phys, vol.4, pp.487-517, 2003. ,
Flavin and pyridine nucleotide oxidation-reduction changes in perfused rat liver, J. Biol. Chem, vol.244, pp.2317-2324, 1969. ,
Idiopathic Pulmonary Fibrosis, Drugs, vol.161, issue.4, pp.405-430, 2004. ,
DOI : 10.2165/00003495-200464040-00005
The principles of nonlinear optics, 1984. ,
Optical Second Harmonic Generation at Interfaces, Annual Review of Physical Chemistry, vol.40, issue.1, pp.327-350, 1989. ,
DOI : 10.1146/annurev.pc.40.100189.001551
Resonant scanning optical microscope, Applied Optics, vol.17, issue.18, pp.2879-2882, 1978. ,
DOI : 10.1364/AO.17.002879
Third harmonic generation microscopy, Optics Express, vol.3, issue.9, pp.315-324, 1998. ,
DOI : 10.1364/OE.3.000315.m005
Computation and Analysis of Protein Circular Dichroism Spectra, Numerical Computer Methods, 13 of Methods in Enzymology, pp.318-351, 2004. ,
DOI : 10.1016/S0076-6879(04)83013-1
Quantitative second-harmonic generation microscopy in collagen, Applied Optics, vol.42, issue.25, pp.5209-5219, 2003. ,
DOI : 10.1364/AO.42.005209
Polarization-dependent optical second-harmonic imaging of a rat-tail tendon, Journal of Biomedical Optics, vol.7, issue.2, pp.205-214, 2002. ,
DOI : 10.1117/1.1431967
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo, Nature Medicine, vol.54, issue.6, pp.678-682, 2005. ,
DOI : 10.1006/mvre.1995.1036
Multiharmonic-generation biopsy of skin, Optics Letters, vol.28, issue.24, pp.28-2488, 2003. ,
DOI : 10.1364/OL.28.002488
Polarization of light in nonlinear optics, 1998. ,
A Modified One-Step Trichrome Stain for Demonstration of Fine Connective Tissue Fibers, Stain Technology, vol.1, issue.4, pp.227-231, 1968. ,
DOI : 10.3109/10520296809115073
Separation of a series of chromophores and fluorophores present in elastin, Biochemical Journal, vol.147, issue.2, pp.215-219, 1975. ,
DOI : 10.1042/bj1470215
Introduction to the human body : The essentials of anatomy and physiology, 2004. ,
Linear and nonlinear optical properties of molecules, 1993. ,
Anatomy and ultrastructure of the lung Pulmonary biology in health and disease, 2002. ,
The SCS/ARS/CES Pesticide Properties Database for Environmental Decision-Making, Res. Environ. Contam. Toxicol, vol.123, pp.1-155, 1992. ,
DOI : 10.1007/978-1-4612-2862-2_1
Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light, Basic Res. Cardiol, vol.89, pp.397-410, 1994. ,
Interpreting Second-Harmonic Generation Images of Collagen I Fibrils, Biophysical Journal, vol.88, issue.2, pp.1377-1386, 2005. ,
DOI : 10.1529/biophysj.104.047308
Depth-resolved fluorescence spectroscopy reveals layered structure of tissue, Optics Express, vol.12, issue.14, pp.3218-3223, 2004. ,
DOI : 10.1364/OPEX.12.003218
Measurement of two-photon excitation cross sections of molecular fluorophores with data from 690 to 1050 nm, Journal of the Optical Society of America B, vol.13, issue.3, pp.481-491, 1996. ,
DOI : 10.1364/JOSAB.13.000481
Characterization of collagen orientation in human dermis by two-dimensional second-harmonic-generation polarimetry, Journal of Biomedical Optics, vol.9, issue.2, 2004. ,
DOI : 10.1117/1.1644116
Distribution of type I collagen in human kidney diseases in comparison with type III collagen, The Journal of Pathology, vol.75, issue.2, pp.141-148, 1990. ,
DOI : 10.1002/path.1711620207
Molecular architecture of basement membranes, FASEB J, vol.4, pp.1577-1590, 1990. ,
Live tissue intrinsic emission microscopy using multiphotonexcited native fluorescence and second harmonic generation, Proc. Natl. Acad. Sci. USA, 100, pp.7075-7080, 2003. ,
DOI : 10.1073/pnas.0832308100
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165832
Nonlinear magic: multiphoton microscopy in the biosciences, Nature Biotechnology, vol.21, issue.11, pp.1369-1377, 2003. ,
DOI : 10.1038/nbt899
Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence, Proc. Natl. Acad. Sci. USA, pp.99-11014, 2002. ,
DOI : 10.1073/pnas.172368799