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Vers la synthèse totale de la macrolactine A. Nouvelles substitutions d'alcools propargyliques catalysées par de l'or(III).

Abstract : The first part of this thesis describes a synthetical approach of antimicrobial agent Macrolactin A. This approaoch is based on two original stratégies to build the conjugated systems: one is the isomerisation of a propagylic ketone and the other is a two reaction sequence, namely a Johnson-Claisen reaction followed by an alumina- promoted isomerisation. The stereogenic centres were built by catalytic asymmetric reactions. The second part of the manuscript describes a new nucleophilic substitution of propargylic alcohols catalyzed by a gold(III) complex.
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https://pastel.archives-ouvertes.fr/pastel-00002171
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Submitted on : Thursday, July 29, 2010 - 1:54:24 PM
Last modification on : Monday, June 22, 2020 - 12:08:06 PM
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Marie Georgy. Vers la synthèse totale de la macrolactine A. Nouvelles substitutions d'alcools propargyliques catalysées par de l'or(III).. Chimie organique. Ecole Polytechnique X, 2006. Français. ⟨pastel-00002171⟩

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