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Développement de méthodes physico-chimiques pour le contrôle de la médication par l'Harpagophytum et l'Eleutherococcus, principes actifs utilisés en phytothérapie équine. : Etude par spectrométrie de masse des harpagosides, des éleuthérosides et du cycloarténol, principes actifs utilisés en phytothérapie équine.

Abstract : This five-chaptered manuscript is devo! ted to t he development of physico-chemical methods for the equine medical treatment control of Harpagophytum and Eleutherococcus, active principles used in herbal medicine. The first chapter deals with the objects of the study and presents the botanical and pharmacological properties of the plants of interest: Harpagophytum procumbens and Eleutherococcus senticosus. The second chapter details the experimental and theoretical techniques used: sample preparation, mass spectrometry coupled with liquid or gas chromatography and molecular modeling. The third chapter is presented on the basis of publications; extraction of active principles of Harpagophytum from equine biological samples, LC/MS analysis, as well as a theoretical approach of harpagide cationization by sodium ions and a metabolic approach of harpagoside are developed. A direct application of these results on eleutherosides B and E is shown in the fourth chapter, completed by a research of the active principles in feed suppl! ements. The fifth and last chapter is the outcome of the applications, results and perspectives from the work performed during the last three years.
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https://pastel.archives-ouvertes.fr/pastel-00002923
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Submitted on : Tuesday, July 27, 2010 - 10:50:09 AM
Last modification on : Friday, October 23, 2020 - 4:37:45 PM
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Cyril Colas. Développement de méthodes physico-chimiques pour le contrôle de la médication par l'Harpagophytum et l'Eleutherococcus, principes actifs utilisés en phytothérapie équine. : Etude par spectrométrie de masse des harpagosides, des éleuthérosides et du cycloarténol, principes actifs utilisés en phytothérapie équine.. Chemical Sciences. Ecole Polytechnique X, 2006. English. ⟨pastel-00002923⟩

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