P. Chantre, A. Cappelaere, D. Leblan, D. Guedon, J. Vandermander et al., Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis, Phytomedicine, vol.7, issue.3, pp.177-183, 2000.
DOI : 10.1016/S0944-7113(00)80001-X

J. J. Gagnier, S. Chrubasik, and E. Manheimer, Harpagophytum procumbens for ostheoarthitis and low back pain: a systematic review, BMC Complementary and Alternative Medicine, issue.4, p.13, 2004.

T. Kikuchi, S. Matsuda, Y. Kubo, and T. Namba, New iridoid glycosides from Harpagophytum procumbens DC, Chemical and Pharmaceutical Bulletin, issue.7, pp.31-2296, 1983.

C. Seger, M. Godejohann, L. H. Tseng, and . Lc-dad-ms, SPE-NMR hyphenation ? A tool for the analysis of pharmaceutically used plant extracts: identification of isobaric iridoid glycoside regioisomers from Harpagophytum procumbens, Analytical Chemistry, issue.3, pp.77-878, 2005.

M. Baranska, H. Schulz, R. Siuda, M. A. Strehle, P. Rosch et al., Quality control of Harpagophytum procumbens and its related phytopharmaceutical products by means of NIR-FT-Raman spectroscopy, Biopolymers, issue.1, pp.77-78, 2005.

H. H. Maurer, Liquid chromatography???mass spectrometry in forensic and clinical toxicology, Journal of Chromatography B: Biomedical Sciences and Applications, vol.713, issue.1, pp.3-25, 1998.
DOI : 10.1016/S0378-4347(97)00514-8

S. Paterson, R. Cordero, S. Mcculloch, and P. Houldsworth, Analysis of urine for drugs of abuse using mixed-mode solid-phase extraction and gas chromatographymass spectrometry, Annals of Clinical Biochemistry, issue.5, pp.37-690, 2000.

P. M. Wynne, D. C. Batty, J. H. Vine, and N. J. Simpson, A multi-eluate approach to solid-phase extraction of biological fluids for detection of drug residues, Proceedings of the 13th International Conference of Racing Analysts and Veterinarians, pp.232-240, 2001.

P. M. Wynne, D. C. Batty, J. H. Vine, and N. J. Simpson, An improved method for the automated extraction of anabolic steroids from equine urine, Proceedings of the 13th International Conference of Racing Analysts and Veterinarians, pp.245-251, 2001.

P. M. Wynne, D. C. Batty, J. H. Vine, and N. J. Simpson, Reduced blocking rates through application of a new NC-SPE sorbent to the extraction of equine urine, Proceedings of the 13th International Conference of Racing Analysts and Veterinarians, pp.445-452, 2001.

P. M. Wynne, The application of SPE to veterinary drug abuse in solid-phase extraction, Solid-Phase Extraction ? Principles, Techniques and Applications, pp.273-306, 2000.

D. C. Batty, P. M. Wynne, and J. H. Vine, Comprehensive drug screening using a single solid-phase extraction cartridge, Proceedings of the 11th International Conference of Racing Analysts and Veterinarians, pp.197-202, 1996.

J. Thomas and P. Meffin, Aromatic hydroxylation of lidocaine and mepivacaine in rats and humans, Journal of Medicinal Chemistry, vol.15, issue.10, pp.15-1046, 1972.
DOI : 10.1021/jm00280a013

C. Colas, P. Garcia, M. A. Popot, Y. Bonnaire, and S. Bouchonnet, Liquid chromatography/electrospray ionization mass spectrometric characterization of Harpagophytum in equine urine and plasma, Rapid Communications in Mass Spectrometry, issue.22, pp.20-3257, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00904617

A. Lindström, A. C. Albertsson, and M. Hakkarainen, Development of a solid-phase extraction method for simultaneous extraction of adipic acid, succinic acid and 1,4-butanediol formed during hydrolysis of poly(butylene adipate) and poly(butylene succinate), Journal of Chromatography A, vol.1022, issue.1-2, pp.171-177, 2004.
DOI : 10.1016/j.chroma.2003.09.036

R. Kay, S. Hines, K. Woodward, S. Hudson, and P. Teale, The use of Nexus polymeric phase extraction cartridges as a pre-extraction medium for screening and confirmatory methodologies, Proceedings of the 14th International Conference of Racing Analysts and Veterinarians, pp.243-247, 2003.

M. C. Hennion, Solid-phase extraction: method development, sorbents, and coupling with liquid chromatography, Journal of Chromatography A, vol.856, issue.1-2, pp.3-54, 1999.
DOI : 10.1016/S0021-9673(99)00832-8

P. Bartels, E. Ebeling, B. Krämer, H. Kruse, N. Osius et al., Determination of chlorophenols in urine of children and suggestion of reference values, Fresenius' Journal of Analytical Chemistry, vol.365, issue.5, pp.365-458, 1999.
DOI : 10.1007/s002160051640

M. C. Hennion, C. Cau-dit-coumes, and V. Pichon, Trace analysis of polar organic pollutants in aqueous samples, Journal of Chromatography A, vol.823, issue.1-2, pp.147-161, 1998.
DOI : 10.1016/S0021-9673(98)00479-8

T. Tobin, Drugs and the Performance Horse, 1981.

M. Gravel, K. A. Thompson, M. Zak, C. Bérubé, and D. G. Hall, Universal Solid-Phase Approach for the Immobilization, Derivatization, and Resin-to-Resin Transfer Reactions of Boronic Acids, The Journal of Organic Chemistry, vol.67, issue.1, pp.67-70, 2002.
DOI : 10.1021/jo0106501

J. Hartleb, Y. Damm, R. Arndt, E. Christophers, and E. Stockfleth, Determination of 5-S-cysteinyldopa in plasma and urine using a fully automated solid-phase extraction-highperformance liquid chromatographic method for an improvment of specificity and sensitivity of this prognostic marker of malignant melanoma, Journal of Chromatography B, issue.1, pp.727-758, 1999.

D. C. Batty, N. J. Simpson, J. H. Vine, and P. M. Wynne, A multi-eluate approach to SPE of biological fluids for drugs of abuse analysis ? Part 3, Proceedings of the 14th International Conference of Racing Analysts and Veterinarians, pp.206-214, 2003.

B. Law and S. Weir, Fundamental studies in reversed-phase liquid???solid extraction of basic drugs; III: Sample matrix effects, Journal of Pharmaceutical and Biomedical Analysis, vol.10, issue.7, pp.10-487, 1992.
DOI : 10.1016/0731-7085(92)80069-Y

C. Denekamp and E. Egbaria, Remarkable amine-TFA self assembly, Journal of the American Society for Mass Spectrometry, vol.14, issue.2/3, pp.356-362, 2004.
DOI : 10.1016/j.jasms.2003.11.009

C. Colas, P. Garcia, M. A. Popot, Y. Bonnaire, and S. Bouchonnet, Optimization of Solid-Phase Extraction for the Liquid Chromatography--Mass Spectrometry Analysis of Harpagoside, 8-para-Coumaroyl Harpagide, and Harpagide in Equine Plasma and Urine, Journal of Chromatographic Science, vol.46, issue.2, 2006.
DOI : 10.1093/chromsci/46.2.174

URL : https://hal.archives-ouvertes.fr/hal-00525486

P. Van-eenoo and F. T. Delbeke, Criteria in Chromatography and Mass Spectrometry ? a Comparison Between Regulations in the Field of Residue and Doping Analysis, Chromatographia, vol.275, issue.S1, pp.59-98, 2004.
DOI : 10.1365/s10337-004-0198-8

C. Colas, S. Bouchonnet, F. Rogalewicz-gilard, M. A. Popot, and G. Ohanessian, Proton and Sodium Cation Affinities of Harpagide:?? A Computational Study, The Journal of Physical Chemistry A, vol.110, issue.23, pp.110-7503, 2006.
DOI : 10.1021/jp061526u

URL : https://hal.archives-ouvertes.fr/hal-00904620

E. Botek, J. L. Debrun, B. Hakim, and L. Morin-allory, Attachment of alkali cations on ?-D-glucopyranose: matrix-assisted laser desorption/ionization time-of-flight studies andab initio calculations, Rapid Communications in Mass Spectrometry, vol.334, issue.4, pp.15-273, 2001.
DOI : 10.1002/rcm.222

P. L. Mauri, L. Iemoli, C. Gardana, P. Riso, P. Simonetti et al., Liquid chromatography/electrospray ionization mass spectrometric characterization of flavonol glycosides in tomato extracts and human plasma, Rapid Communications in Mass Spectrometry, issue.10, pp.13-924, 1999.

C. Dall-'asta, S. Sforza, G. Galaverna, A. Dossena, and R. Marchelli, Simultaneous detection of type A and type B trichothecenes in cereals by liquid chromatographyelectrospray ionization mass spectrometry using NaCl as cationization agent, Journal of Chromatography A, vol.1054, issue.12, pp.389-395, 2004.

R. Chen and L. Li, Lithium and trasition metal ions enable low energy collision-induced dissociation of polyglycols in electrospray ionization mass spectrometry, Journal of the American Society for Mass Spectrometry, issue.7, pp.12-832, 2001.

C. Bruggink, R. Maurer, H. Herrmann, S. Cavalli, and F. Hoefler, Analysis of carbohydrates by anion exchange chromatography and mass spectrometry, Journal of Chromatography A, vol.1085, issue.1, pp.1085-104, 2005.
DOI : 10.1016/j.chroma.2005.03.108

M. B. Kostova, M. I. Konaklieva, K. I. Alipieva, S. S. Popov, and N. V. Handjieva, ESI-MS study of some C 10 iridoid glycosides, Instrumentation Science and Technology, issue.6, pp.33-691, 2005.

R. King, R. Bonfiglio, C. Fernandez-metzler, C. Miller-stein, and T. Olah, Mechanistic investigation of ionization suppression in electrospray ionization, Journal of the American Society for Mass Spectrometry, vol.13, issue.11, pp.11-942, 2000.
DOI : 10.1016/S1044-0305(00)00163-X

L. Guillerault, E. Ollivier, R. Elias, and G. Balansard, Determination of Harpagide, 8-Para-Coumaroyl Harpagide, and Harpagoside by High Performance Liquid Chromatography in Harpagophytum Procumbens Drugs and in a Commercial Extract, Journal of Liquid Chromatography, vol.120, issue.13, pp.17-2951, 1994.
DOI : 10.1016/S0021-9673(00)94983-5

S. Heinonen, T. Nurmi, K. Liukkonen, K. Poutanen, K. Wähälä et al., In Vitro Metabolism of Plant Lignans:?? New Precursors of Mammalian Lignans Enterolactone and Enterodiol, Journal of Agricultural and Food Chemistry, vol.49, issue.7, pp.49-3178, 2001.
DOI : 10.1021/jf010038a

P. J. Medon, P. W. Ferguson, and C. F. Watson, Effects of Eleutherococcus senticosus extracts on hexobarbital metabolism in vivo and in vitro, Journal of Ethnopharmacology, vol.10, issue.2, pp.235-241, 1984.
DOI : 10.1016/0378-8741(84)90005-9

M. L. Andersen, E. H. Santos, M. L. Seabra, D. Silva, A. A. Tulfik et al., Evaluation of acute and chronic treatments with Harpagophytum procumbens on Freund???s adjuvant-induced arthritis in rats, Journal of Ethnopharmacology, vol.91, issue.2-3, pp.325-330, 2004.
DOI : 10.1016/j.jep.2004.01.003

P. Chantre, A. Cappelaere, D. Leblan, D. Guedon, J. Vandermander et al., Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis, Phytomedicine, vol.7, issue.3, pp.177-183, 2000.
DOI : 10.1016/S0944-7113(00)80001-X

J. J. Gagnier, S. Chrubasik, and E. Manheimer, Harpagophytum procumbens for ostheoarthitis and low back pain: a systematic review, BMC Complementary and Alternative Medicine, issue.4, p.13, 2004.

M. Baranska, H. Schultz, R. Siuda, M. A. Strehle, P. Rosch et al., Quality control of Harpagophytum procumbens and its related phytopharmaceutical products by means of NIR-FT-Raman spectroscopy, Biopolymers, issue.1, pp.77-78, 2005.

C. Colas, P. Garcia, M. A. Popot, Y. Bonnaire, and S. Bouchonnet, Optimization of Solid-Phase Extraction for the Liquid Chromatography--Mass Spectrometry Analysis of Harpagoside, 8-para-Coumaroyl Harpagide, and Harpagide in Equine Plasma and Urine, Journal of Chromatographic Science, vol.46, issue.2, 2007.
DOI : 10.1093/chromsci/46.2.174

URL : https://hal.archives-ouvertes.fr/hal-00525486

R. Orlando, C. A. Bush, and C. Fenselau, Structural analysis of oligosaccharides by tandem mass spectrometry: Collisional activation of sodium adduct ions, Biological Mass Spectrometry, vol.19, issue.12, pp.19-747, 1990.
DOI : 10.1002/bms.1200191202

M. H. Amad, N. B. Cech, G. S. Jackson, and C. G. Enke, Importance of gas-phase proton affinities in determining the electrospray ionization response for analytes and solvents, Journal of Mass Spectrometry, vol.35, issue.187, pp.35-784, 2000.
DOI : 10.1002/1096-9888(200007)35:7<784::AID-JMS17>3.0.CO;2-Q

M. J. Dewar, E. G. Zoebisch, E. F. Healy, and J. P. Stewart, AM1: a new general purpose quantum mechanical molecular model, Journal of the American Chemical Society, issue.13, pp.107-3902, 1985.

E. Brothers and M. K. Jr, Sodium Parameters for AM1 and PM3 Optimized Using a Modified Genetic Algorithm, The Journal of Physical Chemistry B, vol.106, issue.10, pp.106-2779, 2002.
DOI : 10.1021/jp012637q

. Hypercube, HyperChem? Professional 7.51, Hypercube Inc., 1115 NW 4th Street

T. Kikuchi, S. Matsuda, Y. Kubo, and T. Namba, New iridoid glycosides from Harpagophytum procumbens DC, Chemical and Pharmaceutical Bulletin, issue.7, pp.31-2296, 1983.

B. Baghdikian, H. Guiraud-dauriac, E. Ollivier, A. N-'guyen, G. Dumenil et al., Formation of nitrogen-containing metabolites from the main iridoids of Harpagophytum procumbens and H. zeyheri by human intestinal bacteria, Planta Medica, issue.2, pp.65-164, 1999.

M. Vanhaelen, R. Vanhaelen, J. Samaey-fontaine, A. Elchamid, P. Niebes et al., Aspects botaniques, constitution chimique et activite pharacologique d'Harpagophytum procumbens DC, pp.7-13, 1983.

S. Heinonen, T. Nurmi, K. Liukkonen, K. Poutanen, K. Wähälä et al., In Vitro Metabolism of Plant Lignans:?? New Precursors of Mammalian Lignans Enterolactone and Enterodiol, Journal of Agricultural and Food Chemistry, vol.49, issue.7, pp.49-3178, 2001.
DOI : 10.1021/jf010038a

S. Oikarinen, S. M. Heinonen, T. Nurmi, H. Adlercreutz, and M. Mutanen, No effect on adenoma formation in Min mice after moderate amount of flaxseed, European Journal of Nutrition, vol.13, issue.5, pp.44-273, 2005.
DOI : 10.1007/s00394-004-0521-z

. Analytical, Lignans in selected wines, Food Chemistry, vol.83, issue.2, pp.303-309, 2003.

D. H. Kim, K. T. Lee, E. A. Bae, M. J. Han, and H. J. Park, Metabolism of liriodendrin and syringin by human intestinal bacteria and their relation toin vitro cytotoxicity, Archives of Pharmacal Research, vol.37, issue.1, pp.30-34, 1999.
DOI : 10.1007/BF02976432

P. J. Medon, P. W. Ferguson, and C. F. Watson, Effects of Eleutherococcus senticosus extracts on hexobarbital metabolism in vivo and in vitro, Journal of Ethnopharmacology, vol.10, issue.2, pp.235-241, 1984.
DOI : 10.1016/0378-8741(84)90005-9

Z. H. Yan, C. H. Yang, X. H. Wu, and Y. Y. Xie, The first facile synthesis of (±)-syringaresinol, Chinese Chemical Letters, vol.15, issue.4, pp.408-410, 2004.

F. Lu and J. Ralph, Highly Selective Syntheses of Coniferyl and Sinapyl Alcohols, Journal of Agricultural and Food Chemistry, vol.46, issue.5, pp.1794-1796, 1998.
DOI : 10.1021/jf970953p

B. Vermes, O. Seligmann, and H. Wagner, Synthesis of biologically active tetrahydrofurofuranlignan-(syringin, pinoresinol)-mono-and bis-glucosides, Phytochemistry, issue.9, pp.30-3087, 1991.

H. J. Jung, H. J. Park, R. G. Kim, K. M. Shin, J. Ha et al., In vivo anti-inflammatory and antinoceptive effects of liriodendrin isolated from stem bark of Acanthopanax senticosus, Planta Medica, issue.7, pp.69-610, 2003.

S. D. Jolad, J. J. Hoffman, and J. R. Cole, Cytotoxic agent from Penstemon deustus (Scrophulariaceae): isolation and stereochemistry of liriodendrin, a symmetrically substituted furofuranoid lignan diglucoside, Journal of Organic Chemistry, issue.7, pp.45-1327, 1980.

. Analytical, A simplified HPLC method for total isoflavones in soy products, Food Chemistry, vol.87, issue.2, pp.297-305, 2004.

K. Ishii, T. Furuta, and Y. Kasuya, Determination of rutin in human plasma by high-performance liquid chromatography utilizing solid-phase extraction and ultraviolet detection, Journal of Chromatography B: Biomedical Sciences and Applications, vol.759, issue.1, pp.161-168, 2001.
DOI : 10.1016/S0378-4347(01)00224-9

V. A. Semenov, R. D. Seifulla, and A. P. Azizov, Kondrat'eva I.I. Chromatomass-spectrometric identification of eleutherosides in Eleutherococcus preparations and study of the pharmacokinetics of elton in the human organism under physical loading conditions Association of Official Racing Chemists. AORC guidelines for the minimum criteria for identification by chromatography and mass spectrometry, MS Criteria Working group, Internal communication to AORC members, International Laboratory Accreditation Cooperation. ILAC G7:1996, Accreditation Requirements and Operating Criteria for Horseracing Laboratories, pp.264-266, 1996.

/. S. Monographs, Harpagophiti radix ? Devil's claw root Thieme, pp.233-240, 2003.

S. Chrubasik, O. Künzel, J. Thanner, C. Conradt, and A. Black, A 1-year follow-up after a pilot study with Doloteffin?? for low back pain, Phytomedicine, vol.12, issue.1-2, pp.1-9, 2005.
DOI : 10.1016/j.phymed.2004.01.005

P. Chantre, A. Cappelaere, D. Leblan, D. Guedon, J. Vandermander et al., Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis, Phytomedicine, vol.7, issue.3, pp.177-183, 2000.
DOI : 10.1016/S0944-7113(00)80001-X

C. Seger, M. Godejohann, L. H. Tseng, and . Lc-dad-ms, SPE-NMR hyphenation ? A tool for the analysis of pharmaceutically used plant extracts: identification of isobaric iridoid glycoside regioisomers from Harpagophytum procumbens, Analytical Chemistry, issue.3, pp.77-878, 2005.

M. Baranska, H. Schulz, R. Siuda, M. A. Strehle, P. Rosch et al., Quality control of Harpagophytum procumbens and its related phytopharmaceutical products by means of NIR-FT-Raman spectroscopy, Biopolymers, issue.1, pp.77-78, 2005.

C. Colas, P. Garcia, M. A. Popot, Y. Bonnaire, and S. Bouchonnet, Liquid chromatography/electrospray ionization mass spectrometric characterization of Harpagophytum in equine urine and plasma, Rapid Communications in Mass Spectrometry, issue.22, pp.20-3257, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00904617

C. Colas, P. Garcia, M. A. Popot, Y. Bonnaire, and S. Bouchonnet, Optimization of Solid-Phase Extraction for the Liquid Chromatography--Mass Spectrometry Analysis of Harpagoside, 8-para-Coumaroyl Harpagide, and Harpagide in Equine Plasma and Urine, Journal of Chromatographic Science, vol.46, issue.2, 2006.
DOI : 10.1093/chromsci/46.2.174

URL : https://hal.archives-ouvertes.fr/hal-00525486