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Smiles a été réalisée suivant la procédure B à une concentration de 3M durant 4 jours à partir de 0.22 mmol de pyrimidine vinylée IV.36. Le produit a été purifié par chromatographie flash sur gel de silice (80:20 éther de pétrole/éther diéthylique) ,
28 (dq, 1H, J = 16.0, 1.4 Hz, H 8 ) ; 5.89-5.69 (m, 2H, H 6 et H 9 ), pp.1432-1448 ,
85-3.73 (m, 2H, H 11 et H 4 )50 (s, 3H, CH 3 ), pp.69590-69591 ,
38 durant 1 jour Le produit obtenu est purifié sur une plaque préparative (50:50 éther de pétrole/éther diéthylique) ,
40 durant 1 jour Le produit obtenu est purifié sur une plaque préparative ,
42 durant 2 jours Le produit obtenu est purifié sur une plaque préparative (50:50 éther de pétrole/éther diéthylique) ,
56 (dt, 1H, J = 12.2, 1.5 Hz1 Hz, H 4 )02 (dt, 1H, J = 14.1, 3.3 Hz, H 5 ) ; 3.80-3.69 (m, 1H, H 9 ), RMN 1 H (CDCl 3 ; 400 MHz) 6.9277-2.67 (m, 1H, H 6 ), pp.27-33 ,
25 (d, 1H, J = 5.1 Hz, H ar )86 (s, 1H, H 1 ), pp.34-41 ,