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I. Ugi and R. Meyr, 14 La structure particulière des isonitriles a été le sujet à de nombreuses discussions. Ils peuvent être représentés avec un carbone divalent et sous forme zwitterionique. Les carbènes possèdent également un atome de carbone divalent mais ces derniers contrairement aux isonitriles, en l'absence d'encombrement stérique important dimérisent rapidement, Chem. Ber, vol.93, issue.239, 1960.

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V. I. Tyvorskii, D. N. Bobrov, O. G. Kulinkovich, K. A. Tehrani, and N. De-kimpe, Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1H-pyrazolo[4,3-c]pyridines, Tetrahedron, vol.57, issue.10, pp.2051-2055, 2001.
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S. D. Cho, Y. D. Park, J. J. Kim, S. G. Lee, C. Ma et al., ][1,4]oxazin-2-ones, The Journal of Organic Chemistry, vol.68, issue.20, pp.7918-7920, 2003.
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J. B. 57-baudin, G. Hareau, S. A. Julia, and O. Ruel, A direct synthesis of olefins by reaction of carbonyl compounds with lithio derivatives of 2-[alkyl- or (2???-alkenyl)- or benzyl-sulfonyl]-benzothiazoles., Tetrahedron Letters, vol.32, issue.9, pp.1175-1178, 1991.
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P. Beak, J. B. Covington, S. G. Smith, J. M. White, and J. M. Zeigler, Displacement of protomeric equilibriums by self-association: hydroxypyridine-pyridone and mercaptopyridine-thiopyridone isomer pairs, The Journal of Organic Chemistry, vol.45, issue.8, pp.1354-1362, 1980.
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V. Perrier, A. C. Wallace, K. Kanedo, J. Safar, S. B. Prusiner et al., Mimicking dominant negative inhibition of prion replication through structure-based drug design, Proceedings of the National Academy of Sciences, vol.97, issue.11, pp.6073-6078, 2000.
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U. La-réaction, Smiles a été réalisée suivant la procédure B à une concentration de 3M durant 4 jours à partir de 0.22 mmol de pyrimidine vinylée IV.36. Le produit a été purifié par chromatographie flash sur gel de silice (80:20 éther de pétrole/éther diéthylique)

3. , 1. , 1. , J. =. 1h, and J. =. , 28 (dq, 1H, J = 16.0, 1.4 Hz, H 8 ) ; 5.89-5.69 (m, 2H, H 6 et H 9 ), pp.1432-1448

1. Hzdd, J. =. 4h, and H. Cy, 85-3.73 (m, 2H, H 11 et H 4 )50 (s, 3H, CH 3 ), pp.69590-69591

I. Mmol-du-diène, 38 durant 1 jour Le produit obtenu est purifié sur une plaque préparative (50:50 éther de pétrole/éther diéthylique)

I. Mmol-du-diène, 40 durant 1 jour Le produit obtenu est purifié sur une plaque préparative

I. Mmol-du-diène, 42 durant 2 jours Le produit obtenu est purifié sur une plaque préparative (50:50 éther de pétrole/éther diéthylique)

1. , 1. , J. =. 5h, and H. Cy, 56 (dt, 1H, J = 12.2, 1.5 Hz1 Hz, H 4 )02 (dt, 1H, J = 14.1, 3.3 Hz, H 5 ) ; 3.80-3.69 (m, 1H, H 9 ), RMN 1 H (CDCl 3 ; 400 MHz) 6.9277-2.67 (m, 1H, H 6 ), pp.27-33

1. and J. =. 5h, 25 (d, 1H, J = 5.1 Hz, H ar )86 (s, 1H, H 1 ), pp.34-41