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La viscérosensibilité chimique intestinale: Mécanismes et implications dans le contrôle de la prise alimentaire chez le rat

Nicolas Darcel
Abstract : INTRODUCTION: Although, the implication of intestinal chemosensitivity in the control of food intake is now widely accepted, its precise mechanisms and its modalities of communication with the central nervous system remain poorly understood. OBJECTIVE: the aim of this study was to refine our understanding of nutrient detection within the intestine and to determine the involvement of vagal pathways in the transfer of visceral information from the gastrointestinal tract to the brain. RESULTS: the present study supports the hypothesis proposing that the intestine can be considered also as a sensory organ. It also appeared that the vagus nerve does play a role in transmitting visceral information to the brain. CONCLUSIONS: Vagally mediated intestinal chemosensitivity should be regarded as a sensory system having a strong influence on food intake control. Understanding its implications in energy homeostatic control will undoubtedly lead to develop new therapies to fight the present obesity epidemics.
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Nicolas Darcel. La viscérosensibilité chimique intestinale: Mécanismes et implications dans le contrôle de la prise alimentaire chez le rat. Life Sciences [q-bio]. INAPG (AgroParisTech), 2005. English. ⟨NNT : 2005INAP0010⟩. ⟨pastel-00003115⟩

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