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Interaction toxine-cellule étudiée par imagerie individuelle de nanoparticules d'oxyde fluorescentes.

Abstract : This thesis has been carried out at the Laboratory for Optics and Biosciences (LOB, Ecole Polytechnic) under the direction of Antigoni Alexandrou. One of the themes of this laboratory is the development and application in the field of biology of a new type of nanometer-sized fluorescent probes. These nanoparticles (NPs) consist of a matrix of yttrium vanadate doped with europium ions (Y1-xEuxVO4) are individually detectable by optical microscopy through the fluorescence they emit. NPs These can be further functionalized to be linked to a biomolecule which one seeks to determine the activity, location or even the dynamics. They join a long line of fluorescent probes which we will briefly describe the various developments. This work has benefited from collaboration with the team Thierry and Jean-Pierre Gacoin BOILOT Laboratory of Condensed Matter Physics (LPMC, Ecole Polytechnique) for the synthesis and functionalization of NPs with the team of Michel Robert Popoff Unit Anaerobic Bacteria and Toxins (TAO, Pasteur Institute) for monitoring and ε toxin with that of Pierre-Louis Tharaux of Cardiovascular Research Centre Inserm Lariboisière for the study of vascular signaling of endothelin- 1.
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Submitted on : Tuesday, July 27, 2010 - 2:18:14 PM
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  • HAL Id : pastel-00003731, version 1



Didier Casanova. Interaction toxine-cellule étudiée par imagerie individuelle de nanoparticules d'oxyde fluorescentes.. Sciences du Vivant [q-bio]. Ecole Polytechnique X, 2008. Français. ⟨pastel-00003731⟩



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