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Caractérisation de l'effet satiétogène des protéines et mécanismes centraux impliqués. Cas particulier des protéines et peptides de levure.

Abstract : The involvement of proteins in regulation of energy intake and especially their potency in inducing satiety has been extensively studied lately. The fact that among macronutrients proteins are the most potent in reducing energy intake is widely acknowledged but mechanisms underlying this effect are mostly controversial or unknown. In addition, the impact of the nature of the proteins used on this effect remains unclear. The purpose of this work is to study in a first part the activation of brain areas known to be involved in regulation of energy intake, after describing the bibliographic data regarding these networks. In a second part, we studied the anorectic effect of yeast extracts developed by Bio-Springer and their action on central nervous system. Our results show that proteins activate areas tha t regulate short and mid-term energy intake and especially noradrenergic pathway in the nucleus of the solitary tract and melanocortin pathway in the arcuate nucleus of the hypothalamus. This effect would appear along with an inhibition of neuronal pathway linked to the hedonic value of the food, and specifically the palatability. Moreover, proteins do not trigger the anterior pyriform cortex, a brain area known to be able to detect amino acid deficiency. Regarding yeast proteins and peptides, we showed that these extracts induce a stronger anorectic response than other proteins both in rat and in Human, and yeast peptides reduce daily energy intake even after habituation. This anorectic effect occurs along with a stronger activation of melanocortin pathway in the arcuate nucleus of the hypothalamus. Despite similar anorectic effects, yeast proteins and peptides presumably have different mechanisms of action.
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https://pastel.archives-ouvertes.fr/pastel-00003790
Contributor : Ecole Agroparistech <>
Submitted on : Tuesday, June 3, 2008 - 8:00:00 AM
Last modification on : Friday, May 29, 2020 - 9:54:02 PM
Long-term archiving on: : Friday, September 10, 2010 - 12:36:13 PM

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Rodolphe Faipoux. Caractérisation de l'effet satiétogène des protéines et mécanismes centraux impliqués. Cas particulier des protéines et peptides de levure.. Life Sciences [q-bio]. INAPG (AgroParisTech), 2007. English. ⟨pastel-00003790⟩

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