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Biomechanical and physio-pathological models for brain medical image analysis.

Olivier Clatz 
Abstract : This manuscript presents different contribution to the development of algorithmic models of the brain and its pathologies. The common characteristic of this work is a so-called "second generation" model, specific to the patient geometry able to simulate the biomechanical behavior of the brain. The first part of this thesis is dedicated to the application of this model to estimate the brain deformation during two neurosurgical procedures: electro-stimulation for the treatment of Parkinson disease and tumor resection. In the first case, the predictive power of the model is used to simulate the intraoperative deformation based on preoperative data. In the second, the model is used in conjunction with intraoperative MR images to asses the physical brain displacement from the images. In the second part of this thesis, we investigate a new class of models, including cerebral pathologies. We propose a new 3D model of high pressure hydrocephalus. In this model, we introduce the coupling of a scalar with a volumetric model to improve the dynamic behavior of the model in surgical simulation. Then we propose a new model of the growth of glioblastomas. The tumor cell density evolution is computed with an anisotropic reaction diffusion equation taking into account the white matter fiber direction, while the coupling with the mechanical model is introduced through a new constitutive equation. Preliminary results obtained on a patient dataset open new potentialities for clinical applications of major importance.
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Submitted on : Friday, July 4, 2008 - 8:00:00 AM
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  • HAL Id : pastel-00003951, version 1



Olivier Clatz. Biomechanical and physio-pathological models for brain medical image analysis.. Engineering Sciences [physics]. École Nationale Supérieure des Mines de Paris, 2006. English. ⟨pastel-00003951⟩



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