Excision du marqueur de sélection -expression de, p.111 ,
Estimation, p.112 ,
Coloration de cellules au rouge Nil, p.112 ,
117 A. Physiologie de l'accumulation des lipides chez Y, p.118 ,
120 B.1 Souches de référence, p.120 ,
127 C.1 Définition des approches mises en oeuvre pour l'ingénierie métabolique, p.129 ,
136 D.1 Analyse fonctionnelle des acyltransférases, p.137 ,
147 E.1 Construction des vecteurs d'expression et des mutants, p.147 ,
Cloning of the yeast FAS3 gene and primary structure of yeast acetyl-CoA carboxylase., Proceedings of the National Academy of Sciences, vol.89, issue.10, pp.4534-4542, 1992. ,
DOI : 10.1073/pnas.89.10.4534
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Research, vol.25, issue.17, pp.3389-3402, 1997. ,
DOI : 10.1093/nar/25.17.3389
have distinct roles in osmoadaptation and redox regulation, The EMBO Journal, vol.56, issue.9, pp.2179-87, 1997. ,
DOI : 10.1093/emboj/16.9.2179
Biosynthesis of phosphatidic acid in lipid particles and endoplasmic reticulum of Saccharomyces cerevisiae., Journal of Bacteriology, vol.179, issue.24, pp.7611-7617, 1997. ,
DOI : 10.1128/jb.179.24.7611-7616.1997
The life cycle of neutral lipids: synthesis, storage and degradation, Cellular and Molecular Life Sciences, vol.63, issue.12, pp.1355-69, 2006. ,
DOI : 10.1007/s00018-006-6016-8
Lipid particle composition of the yeastYarrowia lipolytica depends on the carbon source, PROTEOMICS, vol.279, issue.5, pp.1450-1459, 2006. ,
DOI : 10.1002/pmic.200500339
Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae, J Bacteriol, vol.181, pp.6441-6449, 1999. ,
Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast, Proceedings of the National Academy of Sciences, vol.97, issue.7, pp.3254-3263, 2000. ,
DOI : 10.1073/pnas.97.7.3254
Yarrowia lipolytica, Non conventional Yeasts in Biotechnology. K. Wolf. Berlin, vol.25, pp.313-388, 1996. ,
DOI : 10.1007/978-3-642-38583-4
Functional genetics of Yarrowia lipolytica. Fuctional Genetics of industrial yeasts, pp.227-271, 2003. ,
Cloning of the isocitrate lyase gene (ICL1) from Yarrowia lipolytica and characterization of the deduced protein, MGG Molecular & General Genetics, vol.241, issue.3-4, pp.422-452, 1993. ,
DOI : 10.1007/BF00284696
CELL BIOLOGY: Great Balls of Fat, Science, vol.311, issue.5765, pp.1232-1236, 2006. ,
DOI : 10.1126/science.311.5765.1232
Fatty acid desaturation: variations on an oxidative theme, Current Opinion in Chemical Biology, vol.6, issue.5, pp.577-82, 2002. ,
DOI : 10.1016/S1367-5931(02)00365-4
Yarrowia lipolytica: A model and a tool to understand the mechanisms implicated in lipid accumulation, Biochimie, vol.91, issue.6, pp.692-696, 2009. ,
DOI : 10.1016/j.biochi.2009.02.004
Control of Lipid Accumulation in the Yeast Yarrowia lipolytica, Applied and Environmental Microbiology, vol.74, issue.24, 2008. ,
DOI : 10.1128/AEM.01412-08
Control of Lipid Accumulation in the Yeast Yarrowia lipolytica, Applied and Environmental Microbiology, vol.74, issue.24, pp.7779-89, 2008. ,
DOI : 10.1128/AEM.01412-08
Characterization of FadL-specific fatty acid binding in Escherichia coli, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol.1046, issue.1, pp.97-105, 1990. ,
DOI : 10.1016/0005-2760(90)90099-J
Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes, J Lipid Res, vol.36, pp.1211-1237, 1995. ,
Two upstream activation sequences control the expression of the XPR2 gene in the yeast Yarrowia lipolytica., Molecular and Cellular Biology, vol.14, issue.1, pp.327-365, 1994. ,
DOI : 10.1128/MCB.14.1.327
Nutritional regulation of yeast delta-9 fatty acid desaturase activity., Journal of Bacteriology, vol.171, issue.12, pp.6409-6422, 1989. ,
DOI : 10.1128/jb.171.12.6409-6413.1989
Structural organization and mapping of the human mitochondrial glycerol phosphate dehydrogenase-encoding gene and pseudogene, Gene, vol.172, issue.2, pp.309-321, 1996. ,
DOI : 10.1016/0378-1119(96)00019-4
Fatty acid composition of leaf lipids determined after combined digestion and fatty acid methyl ester formation from fresh tissue, Analytical Biochemistry, vol.152, issue.1, pp.141-146, 1986. ,
DOI : 10.1016/0003-2697(86)90132-6
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis, Proceedings of the National Academy of Sciences, vol.95, issue.22, pp.13018-13041, 1998. ,
DOI : 10.1073/pnas.95.22.13018
Changes of the compositional asymmetry of phospholipids associated to the increment in the membrane surface potential, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1067, issue.2, pp.139-183, 1991. ,
DOI : 10.1016/0005-2736(91)90035-7
Accumulation d'acylglycérols par des espèces levuriennes à usage carburant aéronautique : physiologie et performances de procédés, p.283, 2009. ,
The phospholipid requirement for activity of the lactose carrier of Escherichia coli, J Biol Chem, vol.259, pp.10150-10158, 1984. ,
Coordinated regulation and inositol-mediated and fatty acid-mediated repression of fatty acid synthase genes in Saccharomyces cerevisiae., Proceedings of the National Academy of Sciences, vol.89, issue.21, pp.10232-10238, 1992. ,
DOI : 10.1073/pnas.89.21.10232
Complementation of mutations and nucleotide sequence of FAS1 gene encoding beta subunit of yeast fatty acid synthase, J Biol Chem, vol.262, pp.4231-4271, 1987. ,
Regulatory elements that control transcription activation and unsaturated fatty acid-mediated repression of the Saccharomyces cerevisiae OLE1 gene, J Biol Chem, vol.271, pp.3581-3590, 1996. ,
Isolation of the catalase A gene of Saccharomyces cerevisiae by complementation of the cta1 mutation, MGG Molecular & General Genetics, vol.76, issue.1, pp.74-83, 1985. ,
DOI : 10.1007/BF00383315
Efficient selection of hygromycin-B-resistant Yarrowia lipolytica transformants, Appl Microbiol Biotechnol, vol.46, pp.143-148, 1996. ,
Synthesis, storage and degradation of neutral lipids in yeast, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1771, issue.3, 2006. ,
DOI : 10.1016/j.bbalip.2006.07.001
Synthesis, storage and degradation of neutral lipids in yeast, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1771, issue.3, pp.299-309, 2007. ,
DOI : 10.1016/j.bbalip.2006.07.001
Structural and Biochemical Properties of Lipid Particles from the Yeast Saccharomyces cerevisiae, Journal of Biological Chemistry, vol.283, issue.25, pp.17065-74, 2008. ,
DOI : 10.1074/jbc.M800401200
Regulation of lecithin-cholesterol acyltransferase reaction by acyl acceptors and demonstration of its "idling" reaction, J Biol Chem, vol.268, pp.19334-19374, 1993. ,
Phospholipid:diacylglycerol acyltransferase: An enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants, Proceedings of the National Academy of Sciences, vol.97, issue.12, pp.6487-92, 2000. ,
DOI : 10.1073/pnas.120067297
Biochemistry, cell biology and molecular biology of lipids ofSaccharomyces cerevisiae, Yeast, vol.267, issue.16, pp.1471-510, 1998. ,
DOI : 10.1002/(SICI)1097-0061(199812)14:16<1471::AID-YEA353>3.0.CO;2-Y
New Yarrowia lipolytica transformants used for expression and secretion of heterologous proteins, especially prorennin and human anaphylatoxin C5a, European Patent Application EP 86, p.839, 1987. ,
EVOLUTION OF THE ATP-BINDING CASSETTE (ABC) TRANSPORTER SUPERFAMILY IN VERTEBRATES, Annual Review of Genomics and Human Genetics, vol.6, issue.1, pp.123-165, 2005. ,
DOI : 10.1146/annurev.genom.6.080604.162122
Study on fatty acid binding by proteins in yeast. Dissimilar results in Saccharomyces cerevisiae and Yarrowia lipolytica, Comp Biochem Physiol B, vol.102, pp.261-266, 1992. ,
Molecular inroads into the regulation and metabolism of fatty acids, lessons from bacteria, Progress in Lipid Research, vol.38, issue.2, pp.129-97, 1999. ,
DOI : 10.1016/S0163-7827(98)00022-8
A novel application of solid state culture: production of lipases by Yarrowia lipolytica, Biotechnology Letters, vol.25, issue.15, pp.1225-1234, 2003. ,
DOI : 10.1023/A:1025068205961
<i>Yarrowia lipolytica</i>: An Organism Amenable to Genetic Manipulation as a Model for Analyzing Dimorphism in Fungi, Contrib. Microbiol, vol.5, pp.151-72, 2000. ,
DOI : 10.1159/000060349
Mechanism and kinetics of transfer of a fluorescent fatty acid between single-walled phosphatidylcholine vesicles, Biochemistry, vol.19, issue.1, pp.108-124, 1980. ,
DOI : 10.1021/bi00542a017
The upstream region of the FOX3 gene encoding peroxisomal 3-oxoacyl-coenzyme A thiolase in Saccharomyces cerevisiae contains ABF1- and replication protein A-binding sites that participate in its regulation by glucose repression., Molecular and Cellular Biology, vol.15, issue.6, pp.3405-3419, 1995. ,
DOI : 10.1128/MCB.15.6.3405
A Specific Structural Requirement for Ergosterol in Long-chain Fatty Acid Synthesis Mutants Important for Maintaining Raft Domains in Yeast, Molecular Biology of the Cell, vol.13, issue.12, pp.4414-4442, 2002. ,
DOI : 10.1091/mbc.E02-02-0116
The Acyl-CoA Synthetases Encoded within FAA1 andFAA4 in Saccharomyces cerevisiaeFunction as Components of the Fatty Acid Transport System Linking Import, Activation, and Intracellular Utilization, Journal of Biological Chemistry, vol.276, issue.40, pp.37051-37060, 2001. ,
DOI : 10.1074/jbc.M100884200
Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling, Biochemical Journal, vol.323, issue.1, pp.1-12, 1997. ,
DOI : 10.1042/bj3230001
A yeast sterol carrier protein with fatty-acid and fatty-acyl-CoA binding activity, Archives of Biochemistry and Biophysics, vol.453, issue.2, pp.197-206, 2006. ,
DOI : 10.1016/j.abb.2006.06.024
Identification and characterisation of LIP7 and LIP8 genes encoding two extracellular triacylglycerol lipases in the yeast Yarrowia lipolytica, Fungal Genetics and Biology, vol.42, issue.3, pp.264-74, 2005. ,
DOI : 10.1016/j.fgb.2004.12.003
New disruption cassettes for rapid gene disruption and marker rescue in the yeast Yarrowia lipolytica, Journal of Microbiological Methods, vol.55, issue.3, pp.727-764, 2003. ,
DOI : 10.1016/j.mimet.2003.07.003
Overproduction of lipase by Yarrowia lipolytica mutants, Applied Microbiology and Biotechnology, vol.63, issue.2, pp.136-178, 2003. ,
DOI : 10.1007/s00253-003-1342-3
A simple method for the isolation and purification of total lipides from animal tissues, J Biol Chem, vol.226, pp.497-509, 1957. ,
Scarcity ofars sequences isolated in a morphogenesis mutant of the yeastYarrowia lipolytica, Yeast, vol.14, issue.1, pp.25-36, 1991. ,
DOI : 10.1002/yea.320070104
Studies on the source of cholesterol used for steroid biosynthesis in cultured Leydig tumor cells, J Biol Chem, vol.257, pp.14231-14239, 1982. ,
Depletion of Acyl-Coenzyme A-Binding Protein Affects Sphingolipid Synthesis and Causes Vesicle Accumulation and Membrane Defects in Saccharomyces cerevisiae, Molecular Biology of the Cell, vol.12, issue.4, pp.1147-60, 2001. ,
DOI : 10.1091/mbc.12.4.1147
LEU2 directed expression of ?-galactosidase activity and phleomycin resistance in Yarrowia lipolytica, Current Genetics, vol.76, issue.5, pp.369-75, 1987. ,
DOI : 10.1007/BF00378179
Integrative transformation of the yeast Yarrowia lipolytica, Current Genetics, vol.80, issue.1, pp.49-58, 1985. ,
DOI : 10.1007/BF00418493
Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes, Molecular Biology of the Cell, vol.11, issue.12, pp.4241-57, 2000. ,
DOI : 10.1091/mbc.11.12.4241
Effect of n-alkanes on the transport of glucose in Candida sp. strain 107, Biochem J, vol.127, pp.59-60, 1972. ,
Fatty acid-responsive control of mRNA stability. Unsaturated fatty acid-induced degradation of the Saccharomyces OLE1 transcript, J Biol Chem, vol.271, pp.25801-25810, 1996. ,
Nutritional and hormonal regulation of genes for lipogenic enzymes, Proceedings of the Nutrition Society, vol.50, issue.2, pp.115-137, 1991. ,
DOI : 10.1079/PNS19910022
Expression of GUT1, which encodes glycerol kinase in Saccharomyces cerevisiae, is controlled by the positive regulators Adr1p, Ino2p and Ino4p and the negative regulator Opi1p in a carbon source-dependent fashion, Nucleic Acids Research, vol.27, issue.22, pp.4391-4399, 1999. ,
DOI : 10.1093/nar/27.22.4391
Carbon source-dependent transcriptional regulation of the mitochondrial glycerol-3-phosphate dehydrogenase gene, <i>GUT2</i>, from <i>Saccharomyces cerevisiae</i>, Canadian Journal of Microbiology, vol.46, issue.12, pp.1096-100, 2000. ,
DOI : 10.1139/cjm-46-12-1096
Alteration in cellular fatty acid composition as a response to salt, acid, oxidative and thermal stresses in Lactobacillus helveticus, Microbiology, vol.147, issue.8, pp.2255-64, 2001. ,
DOI : 10.1099/00221287-147-8-2255
Variability of the lipolytic activity in Yarrowia lipolytica and its dependence on environmental conditions, International Journal of Food Microbiology, vol.69, issue.1-2, pp.79-89, 2001. ,
DOI : 10.1016/S0168-1605(01)00575-X
is regulated by a signal from inside the peroxisome, The Journal of Cell Biology, vol.181, issue.7, pp.1255-66, 2003. ,
DOI : 10.1016/S0092-8674(00)81457-9
Lipid Biochemistry, 2002. ,
DOI : 10.1007/978-94-011-3062-2
The Role of Lipoproteins in Steroidogenesis and Cholesterol Metabolism in Steroidogenic Glands*, Endocrine Reviews, vol.3, issue.3, pp.3-299, 1982. ,
DOI : 10.1210/edrv-3-3-299
Fatty acid transport: difficult or easy?, J Lipid Res, vol.39, pp.467-81, 1998. ,
The Saccharomyces cerevisiae YBR159w Gene Encodes the 3-Ketoreductase of the Microsomal Fatty Acid Elongase, Journal of Biological Chemistry, vol.277, issue.38, pp.35440-35449, 2002. ,
DOI : 10.1074/jbc.M205620200
Positional asymmetry of fatty acids on lecithin, J Biol Chem, vol.211, pp.313-322, 1954. ,
Acetyl-CoA carboxylase from yeast is an essential enzyme and is regulated by factors that control phospholipid metabolism, J Biol Chem, vol.268, pp.10946-52, 1993. ,
ABC Proteins Bacteria to, 2003. ,
in microsomal stearyl coenzyme A desaturation, Biochemistry, vol.11, issue.20, pp.3689-96, 1972. ,
DOI : 10.1021/bi00770a005
Activation of a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent Processing, Cell, vol.102, issue.5, pp.577-86, 2000. ,
DOI : 10.1016/S0092-8674(00)00080-5
Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: an assessment of their role in regulating protein N- myristoylation and cellular lipid metabolism, The Journal of Cell Biology, vol.127, issue.3, pp.751-62, 1994. ,
DOI : 10.1083/jcb.127.3.751
Vectors for gene expression and amplification in the yeastYarrowia lipolytica, Yeast, vol.184, issue.2, pp.97-113, 2001. ,
DOI : 10.1002/1097-0061(20010130)18:2<97::AID-YEA652>3.0.CO;2-U
Comparison of promoters suitable for regulated overexpression of ??-galactosidase in the alkane-utilizing yeastYarrowia lipolytica, Biotechnology and Bioprocess Engineering, vol.25, issue.5, pp.320-326, 2000. ,
DOI : 10.1007/BF02942206
Evidence that acyl coenzyme A synthetase activity is required for repression of yeast acetyl coenzyme A carboxylase by exogenous fatty acids., Proceedings of the National Academy of Sciences, vol.73, issue.2, pp.386-90, 1976. ,
DOI : 10.1073/pnas.73.2.386
Fatty Acid Flip-Flop in Phospholipid Bilayers Is Extremely Fast, Biochemistry, vol.34, issue.37, pp.11928-11965, 1995. ,
DOI : 10.1021/bi00037a034
THE BIOLOGICAL SYNTHESIS OF PHOSPHOLIPIDS, Biochemistry and Cell Biology, vol.34, issue.2, pp.334-382, 1956. ,
DOI : 10.1139/o56-036
Eukaryotic Phospholipid Biosynthesis, Annual Review of Biochemistry, vol.64, issue.1, pp.315-358, 1995. ,
DOI : 10.1146/annurev.bi.64.070195.001531
Transfer of long-chain fluorescent fatty acids between small and large unilamellar vesicles, Biochemistry, vol.32, issue.8, pp.2053-61, 1993. ,
DOI : 10.1021/bi00059a024
Yeast acyl-CoA-binding protein: acyl-CoA-binding affinity and effect on intracellular acyl-CoA pool size, Biochemical Journal, vol.302, issue.2, pp.479-85, 1994. ,
DOI : 10.1042/bj3020479
The Saccharomyces cerevisiae YLL012/YEH1, YLR020/YEH2, and TGL1 Genes Encode a Novel Family of Membrane-Anchored Lipases That Are Required for Steryl Ester Hydrolysis, Molecular and Cellular Biology, vol.25, issue.5, pp.1655-68, 2005. ,
DOI : 10.1128/MCB.25.5.1655-1668.2005
The pentafunctional FAS1 genes of Saccharomyces cerevisiae and Yarrowia lipolytica are co-linear and considerably longer than previously estimated, Mol Gen Genet, vol.226, pp.310-314, 1991. ,
??-Oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: A century of continued progress, Progress in Lipid Research, vol.34, issue.4, pp.267-342, 1995. ,
DOI : 10.1016/0163-7827(95)00011-9
A simple method for displaying the hydropathic character of a protein, Journal of Molecular Biology, vol.157, issue.1, pp.105-137, 1982. ,
DOI : 10.1016/0022-2836(82)90515-0
DGAT2 Is a New Diacylglycerol Acyltransferase Gene Family: PURIFICATION, CLONING, AND EXPRESSION IN INSECT CELLS OF TWO POLYPEPTIDES FROM MORTIERELLA RAMANNIANA WITH DIACYLGLYCEROL ACYLTRANSFERASE ACTIVITY, Journal of Biological Chemistry, vol.276, issue.42, pp.38862-38871, 2001. ,
DOI : 10.1074/jbc.M106168200
Multiple-copy integration in the yeast Yarrowia lipolytica, Current Genetics, vol.14, issue.1, pp.38-44, 1994. ,
DOI : 10.1007/BF00326302
Dual Localization of Squalene Epoxidase, Erg1p, in Yeast Reflects a Relationship between the Endoplasmic Reticulum and Lipid Particles, Molecular Biology of the Cell, vol.9, issue.2, pp.375-86, 1998. ,
DOI : 10.1091/mbc.9.2.375
Mutant strains of Saccharomyces cerevisiae lacking sphingolipids synthesize novel inositol glycerophospholipids that mimic sphingolipid structures, J Biol Chem, vol.268, pp.845-56, 1993. ,
Crystal structure of delta9 stearoyl-acyl carrier protein desaturase from castor seed and its relationship to other diiron proteins, Embo J, vol.15, pp.4081-92, 1996. ,
The acyl???CoA oxidases from the yeast Yarrowia lipolytica: characterization of Aox2p, Archives of Biochemistry and Biophysics, vol.407, issue.1, pp.32-38, 2002. ,
DOI : 10.1016/S0003-9861(02)00466-6
Purification and Characterization of the Recombinant Form of Acyl CoA Oxidase 3 from the Yeast Yarrowia lipolytica, Archives of Biochemistry and Biophysics, vol.384, issue.1, pp.1-8, 2000. ,
DOI : 10.1006/abbi.2000.2079
Heterologous protein expression and secretion in the non-conventional yeast Yarrowia lipolytica: a review, Journal of Biotechnology, vol.109, issue.1-2, pp.63-81, 2004. ,
DOI : 10.1016/j.jbiotec.2003.10.027
Strong hybrid promoters and integrative expression/secretion vectors for quasi-constitutive expression of heterologous proteins in the yeast Yarrowia lipolytica, J Mol Microbiol Biotechnol, vol.2, pp.207-223, 2000. ,
Sticky-end polymerase chain reaction method for systematic gene disruption in Saccharomyces cerevisiae, Yeast, vol.11, issue.9, pp.859-68, 1996. ,
DOI : 10.1002/(SICI)1097-0061(199607)12:9<859::AID-YEA978>3.0.CO;2-Q
Futile Cycling of Intermediates of Fatty Acid Biosynthesis toward Peroxisomal ??-Oxidation in Saccharomyces cerevisiae, Journal of Biological Chemistry, vol.278, issue.35, pp.32596-32601, 2003. ,
DOI : 10.1074/jbc.M305574200
Phospholipase D, Biochemistry and Cell Biology, vol.82, issue.1, pp.225-53, 2004. ,
DOI : 10.1139/o03-079
Specificity of unsaturated fatty acidregulated expression of the Saccharomyces cerevisiae OLE1 gene, J Biol Chem, vol.267, pp.5931-5937, 1992. ,
Identification of a Class of Saccharomyces cerevisiae Mutants Defective in Fatty Acid Repression of Gene Transcription and Analysis of the frm2 Gene, Yeast, vol.12, issue.4, pp.319-350, 1996. ,
DOI : 10.1002/(SICI)1097-0061(19960330)12:4<319::AID-YEA914>3.3.CO;2-R
A novel cytochrome b5-like domain is linked to the carboxyl terminus of the Saccharomyces cerevisiae delta-9 fatty acid desaturase, J Biol Chem, vol.270, pp.29766-72, 1995. ,
Fah1p, a Saccharomyces cerevisiae Cytochromeb 5 Fusion Protein, and ItsArabidopsis thaliana Homolog That Lacks the Cytochromeb 5 Domain Both Function in the ??-Hydroxylation of Sphingolipid-associated Very Long Chain Fatty Acids, Journal of Biological Chemistry, vol.272, issue.45, pp.28281-28289, 1997. ,
DOI : 10.1074/jbc.272.45.28281
Lipid Accumulation, Lipid Body Formation, and Acyl Coenzyme A Oxidases of the Yeast Yarrowia lipolytica, Applied and Environmental Microbiology, vol.70, issue.7, pp.3918-3942, 2004. ,
DOI : 10.1128/AEM.70.7.3918-3924.2004
Primary structure of the multifunctional alpha subunit protein of yeast fatty acid synthase derived from FAS2 gene sequence, J Biol Chem, vol.263, pp.12315-12340, 1988. ,
Comparison of expression systems in the yeasts Saccharomyces cerevisiae, Hansenula polymorpha, Klyveromyces lactis, Schizosaccharomyces pombe and Yarrowia lipolytica. cloning of two novel promoters from Yarrowia lipolytica, Yeast, vol.14, issue.14, pp.1267-83, 1998. ,
DOI : 10.1002/(SICI)1097-0061(1998100)14:14<1267::AID-YEA327>3.3.CO;2-U
Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain Reaction, Cold Spring Harbor Symposia on Quantitative Biology, vol.51, issue.0, pp.263-73, 1986. ,
DOI : 10.1101/SQB.1986.051.01.032
Endocytosis is required for the growth of vacuolar H, 1994. ,
Mechanisms of lipid-body formation, Trends in Biochemical Sciences, vol.24, issue.3, pp.109-124, 1999. ,
DOI : 10.1016/S0968-0004(98)01349-8
Mga2p Is a Putative Sensor for Low Temperature and Oxygen to Induce OLE1 Transcription in Saccharomyces cerevisiae, Biochemical and Biophysical Research Communications, vol.291, issue.3, pp.707-720, 2002. ,
DOI : 10.1006/bbrc.2002.6507
Engineering of Saccharomyces cerevisiae for the production of ?-glycerol 3-phosphate, Metabolic Engineering, vol.6, issue.2, 2004. ,
DOI : 10.1016/j.ymben.2004.02.005
Expression of invertase activity in Yarrowia lipolytica and its use as a selective marker, Current Genetics, vol.33, issue.4, pp.253-60, 1989. ,
DOI : 10.1007/BF00422111
Méthode d'intégration multiple ciblée chez la levure Yarrowia lipolytica. France, 2008. ,
Protein expression and secretion in the yeast Yarrowia lipolytica, FEMS Yeast Res, vol.2, pp.371-380, 2002. ,
Mutation in the Calcium-Binding Domain of the Mitochondrial Glycerophosphate Dehydrogenase Gene in a Family of Diabetic Subjects, Biochemical and Biophysical Research Communications, vol.231, issue.3, pp.570-572, 1997. ,
DOI : 10.1006/bbrc.1997.6147
Rapid identification and characterization of peroxisomal assembly mutants inYarrowia lipolytica, Yeast, vol.14, issue.5, pp.507-517, 1993. ,
DOI : 10.1002/yea.320090506
The DGA1 Gene Determines a Second Triglyceride Synthetic Pathway in Yeast, Journal of Biological Chemistry, vol.277, issue.11, pp.8877-8881, 2002. ,
DOI : 10.1074/jbc.M111646200
ELO2 and ELO3, Homologues of theSaccharomyces cerevisiae ELO1 Gene, Function in Fatty Acid Elongation and Are Required for Sphingolipid Formation, Journal of Biological Chemistry, vol.272, issue.28, pp.17376-84, 1997. ,
DOI : 10.1074/jbc.272.28.17376
Biogenesis of cytoplasmic lipid droplets: From the lipid ester globule in the membrane to the visible structure, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1791, issue.6, pp.399-407, 2009. ,
DOI : 10.1016/j.bbalip.2008.10.002
Metabolic Engineering of Glycerol Production in Saccharomyces cerevisiae, Applied and Environmental Microbiology, vol.68, issue.6, pp.2814-2835, 2002. ,
DOI : 10.1128/AEM.68.6.2814-2821.2002
Identification and functions of new transporters in yeast mitochondria, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1459, issue.2-3, pp.363-372, 2000. ,
DOI : 10.1016/S0005-2728(00)00173-0
Identification and functional reconstitution of the yeast peroxisomal adenine nucleotide transporter, The EMBO Journal, vol.20, issue.18, pp.5049-59, 2001. ,
DOI : 10.1093/emboj/20.18.5049
Modeling Lipid Accumulation and Degradation in Yarrowia lipolytica Cultivated on Industrial Fats, Current Microbiology, vol.46, issue.6, pp.398-402, 2003. ,
DOI : 10.1007/s00284-002-3907-2
Modeling lipid accumulation and degradation in Yarrowia lipolytica growing in the presence of Teucrium polium L. aqueous extract, Biotechnol Lett, vol.21, pp.747-749, 2003. ,
Single cell oil production by Yarrowia lipolytica growing on an industrial derivative of animal fat in batch cultures, Applied Microbiology and Biotechnology, vol.58, issue.3, pp.308-320, 2002. ,
DOI : 10.1007/s00253-001-0897-0
Members of the Arabidopsis FAE1-like 3-Ketoacyl-CoA Synthase Gene Family Substitute for the Elop Proteins of Saccharomyces cerevisiae, Journal of Biological Chemistry, vol.281, issue.14, pp.9018-9047, 2006. ,
DOI : 10.1074/jbc.M507723200
Premiminary characterisation of the lipase of Mycotorula lipolytica, J Bacteriol, vol.55, pp.593-600, 1948. ,
Characterization of an Extracellular Lipase Encoded by LIP2 in Yarrowia lipolytica, Journal of Bacteriology, vol.182, issue.10, pp.2802-2810, 2000. ,
DOI : 10.1128/JB.182.10.2802-2810.2000
Microbial lipids, 1989. ,
Yeasts, moulds, algae and bacteria as sources of lipids. Technological advances in improved and alternative sources of lipids, academic and professional, pp.235-291, 1994. ,
Regulation of lipid accumulation in oleaginous micro-organisms, Biochemical Society Transactions, vol.30, issue.6, pp.1047-50, 2002. ,
DOI : 10.1042/bst0301047
Fatty acid biosynthesis in microorganisms being used for Single Cell Oil production, Biochimie, vol.86, issue.11, pp.807-822, 2004. ,
DOI : 10.1016/j.biochi.2004.09.017
Oils and fats: production, degradation and utilization by yeasts. Yeast biotechnology and biocatalysis. H. Verachtert and R. De Mot, pp.223-254, 1990. ,
The Biochemistry and Molecular Biology of Lipid Accumulation in Oleaginous Microorganisms, Adv Appl Microbiol, vol.51, pp.1-51, 2002. ,
DOI : 10.1016/S0065-2164(02)51000-5
Oils and fats: production, degradation and utilization by yeasts. Yeast biotechnology and biocatalysis, pp.223-254, 1990. ,
Tagging Morphogenetic Genes by Insertional Mutagenesis in the Yeast Yarrowia lipolytica, Journal of Bacteriology, vol.183, issue.10, pp.3098-3107, 2001. ,
DOI : 10.1128/JB.183.10.3098-3107.2001
Lipids partition caveolin-1 from ER membranes into lipid droplets: updating the model of lipid droplet biogenesis, The FASEB Journal, vol.18, pp.866-874, 2004. ,
DOI : 10.1096/fj.03-0782fje
Molecular cloning of the gene for the yeast homolog (ACB) of diazepam binding inhibitor/endozepine/acyl-CoA-binding protein., Proceedings of the National Academy of Sciences, vol.89, issue.23, pp.11287-91, 1992. ,
DOI : 10.1073/pnas.89.23.11287
Functional differentiation and selective inactivation of multiple Saccharomyces cerevisiae genes involved in verylong-chain fatty acid synthesis, Mol Genet Genomics, vol.269, pp.290-298, 2003. ,
The TAG1 locus of Arabidopsis encodes for a diacylglycerol acyltransferase, Plant Physiology and Biochemistry, vol.37, issue.11, pp.831-840, 1999. ,
DOI : 10.1016/S0981-9428(99)00115-1
Storage Lipid Synthesis Is Non-essential in Yeast, Journal of Biological Chemistry, vol.277, issue.8, pp.6478-6482, 2002. ,
DOI : 10.1074/jbc.M109109200
Functional expression of the cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiae., Molecular and Cellular Biology, vol.7, issue.6, pp.2087-96, 1987. ,
DOI : 10.1128/MCB.7.6.2087
Disruption of the gene encoding the acyl-CoA-binding protein (ACB1) perturbs acyl-CoA metabolism in Saccharomyces cerevisiae, J Biol Chem, vol.271, pp.22514-22535, 1996. ,
Coordinate genetic control of yeast fatty acid synthase genes FAS1 and FAS2 by an upstream activation site common to genes involved in membrane lipid biosynthesis, Embo J, vol.11, pp.107-121, 1992. ,
A Saccharomyces cerevisiae Mutant Defective in Saturated Fatty Acid Biosynthesis, Proceedings of the National Academy of Sciences, vol.67, issue.2, pp.660-666, 1970. ,
DOI : 10.1073/pnas.67.2.660
The pentafunctional FAS1 gene of yeast: its nucleotide sequence and order of the catalytic domains, MGG Molecular & General Genetics, vol.28, issue.3, pp.479-86, 1986. ,
DOI : 10.1007/BF00422073
DESATURATION AND RELATED MODIFICATIONS OF FATTY ACIDS, Annual Review of Plant Physiology and Plant Molecular Biology, vol.49, issue.1, pp.611-641, 1998. ,
DOI : 10.1146/annurev.arplant.49.1.611
Transcriptome profiling to identify genes involved in peroxisome assembly and function, The Journal of Cell Biology, vol.78, issue.2, pp.259-271, 2002. ,
DOI : 10.1126/science.283.5407.1493
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat, Nature Genetics, vol.109, issue.1, pp.87-90, 2000. ,
DOI : 10.1038/75651
A Yeast Strain Lacking Lipid Particles Bears a Defect in Ergosterol Formation, Journal of Biological Chemistry, vol.279, issue.30, 2004. ,
DOI : 10.1074/jbc.M403251200
Synthesis of Triacylglycerols by the Acyl-Coenzyme A:Diacyl-Glycerol Acyltransferase Dga1p in Lipid Particles of the Yeast Saccharomyces cerevisiae, Journal of Bacteriology, vol.184, issue.2, pp.519-543, 2002. ,
DOI : 10.1128/JB.184.2.519-524.2002
Triacylglycerol biosynthesis in yeast, Applied Microbiology and Biotechnology, vol.267, issue.4, pp.289-99, 2003. ,
DOI : 10.1007/s00253-002-1212-4
Isolation and characterization of Saccharomyces cerevisiae mutants defective in glycerol catabolism, J Bacteriol, vol.129, pp.1335-1377, 1977. ,
Cloning and Functional Characterization of a Phospholipid:Diacylglycerol Acyltransferase from Arabidopsis, PLANT PHYSIOLOGY, vol.135, issue.3, pp.1324-1359, 2004. ,
DOI : 10.1104/pp.104.044354
Isolation and characterization of OLE1, a gene affecting fatty acid desaturation from Saccharomyces cerevisiae, J Biol Chem, vol.264, pp.16537-16581, 1989. ,
The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene, J Biol Chem, vol.265, pp.20144-20153, 1990. ,
Metabolism of n-alkanes. The yeast. Metabolism and physiology of yeasts A, pp.261-287, 1989. ,
Fatty acid synthesis and elongation in yeast, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1771, issue.3, pp.255-70, 2007. ,
DOI : 10.1016/j.bbalip.2006.07.004
Metabolic engineering of the yeast Yarrowia lipolytica for the production of long-chain dicarboxylic acids from renewable oil feedstock, 2006. ,
Characterization of Yarrowia lipolytica mutants affected in hydrophobic substrate utilization, Fungal Genetics and Biology, vol.44, issue.6, pp.531-573, 2007. ,
DOI : 10.1016/j.fgb.2006.09.001
URL : https://hal.archives-ouvertes.fr/hal-00164177
Cell biology of lipid droplets, Current Opinion in Cell Biology, vol.20, issue.4, pp.378-85, 2008. ,
DOI : 10.1016/j.ceb.2008.05.009
Isolation and Characterization of a Gene Affecting Fatty Acid Elongation in Saccharomyces cerevisiae, Journal of Biological Chemistry, vol.271, issue.31, pp.18413-18435, 1996. ,
DOI : 10.1074/jbc.271.31.18413
Identification of Two Novel Human Acyl-CoA Wax Alcohol Acyltransferases: MEMBERS OF THE DIACYLGLYCEROL ACYLTRANSFERASE 2 (DGAT2) GENE SUPERFAMILY, Journal of Biological Chemistry, vol.280, issue.15, pp.14755-64, 2005. ,
DOI : 10.1074/jbc.M500025200
Surface structure and properties of plant seed oil bodies, The Journal of Cell Biology, vol.117, issue.2, pp.327-362, 1992. ,
DOI : 10.1083/jcb.117.2.327
Membrane lipids: where they are and how they behave, Nature Reviews Molecular Cell Biology, vol.18, issue.2, pp.112-136, 2008. ,
DOI : 10.1038/nrm2330
Peroxisomal beta -oxidation of polyunsaturated fatty acids in Saccharomyces cerevisiae: isocitrate dehydrogenase provides NADPH for reduction of double bonds at even positions, The EMBO Journal, vol.17, issue.3, pp.677-87, 1998. ,
DOI : 10.1093/emboj/17.3.677
An origin of replication and a centromere are both needed to establish a replicative plasmid in the yeast Yarrowia lipolytica., Molecular and Cellular Biology, vol.17, issue.4, pp.1995-2004, 1997. ,
DOI : 10.1128/MCB.17.4.1995
Increasing seed oil content in oil-seed rape (Brassica napus L.) by over-expression of a yeast glycerol-3-phosphate dehydrogenase under the control of a seed-specific promoter, Plant Biotechnology Journal, vol.15, issue.3, pp.431-472, 2007. ,
DOI : 10.1105/tpc.9.6.909
Generation of glycerophospholipid molecular species in the yeastSaccharomyces cerevisiae. Fatty acid pattern of phospholipid classes and selective acyl turnover atsn-1 andsn-2 positions, Yeast, vol.5, issue.11, pp.1429-1466, 1994. ,
DOI : 10.1002/yea.320101106
Fatty Acid Synthesis and its Regulation, Annual Review of Biochemistry, vol.52, issue.1, pp.537-579, 1983. ,
DOI : 10.1146/annurev.bi.52.070183.002541
Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies, The FASEB Journal, vol.21, issue.1, pp.167-78, 2007. ,
DOI : 10.1096/fj.06-6711com
Cloning, sequencing, and characterization of five genes coding for Acyl-CoA oxidase isozymes in the yeastYarrowia lipolytica, Cell Biochemistry and Biophysics, vol.10, issue.2, pp.165-74, 1999. ,
DOI : 10.1007/BF02738170
Evaluation of acyl coenzyme A oxidase (Aox) isozyme function in the n-alkaneassimilating yeast Yarrowia lipolytica, J. Bacteriol, vol.181, pp.5140-5148, 1999. ,
Sterol Esterification in Yeast: A Two-Gene Process, Science, vol.272, issue.5266, pp.1353-1359, 1996. ,
DOI : 10.1126/science.272.5266.1353
MGA2 or SPT23 is required for transcription of the delta9 fatty acid desaturase gene, OLE1, and nuclear membrane integrity in Saccharomyces cerevisiae, Genetics, vol.151, pp.473-83, 1999. ,
Malic enzyme: the controlling activity for lipid production? Overexpression of malic enzyme in Mucor circinelloides leads to a 2.5-fold increase in lipid accumulation, Microbiology, vol.153, issue.7, pp.2013-2038, 2007. ,
DOI : 10.1099/mic.0.2006/002683-0
New insights into the structure and function of fatty acid-binding proteins, Cellular and Molecular Life Sciences (CMLS), vol.59, issue.7, pp.1096-116, 2002. ,
DOI : 10.1007/s00018-002-8490-y
Morphogenetic behavior of tropical marine yeast Yarrowia lipolytica in response to hydrophobic substrates, J Microbiol Biotechnol, vol.18, pp.1522-1530, 2008. ,
Intracellular lipid particles of eukaryotic cells, Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, vol.1469, issue.2, pp.101-121, 2000. ,
DOI : 10.1016/S0005-2736(00)00294-7
Control of lipid accumulation in the yeast Yarrowia lipolytica ,
Yarrowia lipolytica: A model and a tool to understand the mechanisms implicated in lipid accumulation, Biochimie, vol.91, issue.6, pp.91-692, 2009. ,
DOI : 10.1016/j.biochi.2009.02.004
Yarrowia lipolytica as a Cell Factory for Oleochemical Biotechnology, Handbook of Hydrocarbon and Lipid Microbiology, 2009. ,
DOI : 10.1007/978-3-540-77587-4_223
The hydrocarbon-degrading oleaginous yeast Yarrowia lipolytica, in Handbook of Hydrocarbon and Lipid Microbiology, 2009. ,
Uptake and Assimilation of Hydrophobic Substrates by the Oleaginous Yeast Yarrowia lipolytica, Handbook of Hydrocarbon and Lipid Microbiology, 2009. ,
DOI : 10.1007/978-3-319-20796-4_42-1
Yarrowia lipolytica as a model for bio-oil production, Progress in Lipid Research, vol.48, issue.6, 2009. ,
DOI : 10.1016/j.plipres.2009.08.005
Role of storage lipid proteins in lipid accumulation and lipid profile in the oleaginous yeast Yarrowia lipolytica, Appl Environ Microbiol, 2009. ,
At5g50600 encodes a member of the short-chain dehydrogenase reductase superfamily with 11beta-and 17beta-hydroxysteroid dehydrogenase activities associated with Arabidopsis thaliana seed oil bodies, Biochimie, issue.2, pp.89-222, 2007. ,
Augmentation de l'accumulation de lipide et production de lipide par des souches mutantes de Yarrowia lipolytica, BIF117612 FR2008: déposé Juillet, 2008. ,