69 III, p.72 ,
102 II. Supports d'immobilisation utilisés103 III. Faisabilité de l'oligoextraction : caractérisation des oligoadsorbants anti-cocaïne synthétisés, p.109 ,
124 A. Influence sur la rétention non spécifique, p.127 ,
138 VI Influence de la composition du tampon sur la rétention 139 A. Données sur l'influence des ions divalents sur l'aptamère anti 139 B. Étude de l'influence des ions divalents sur l'aptamère anti-cocaïne 140 C. Commentaires sur les évolutions de la procédure de synthèse, p.142 ,
162 A. Oligoadsorbant à base d'agarose activée streptavidine 162 B. Oligoextraction de vin sur le support à base de sepharose, CNBr, p.163 ,
168 Références bibliographiques [1] P. Jatlow, The Yale journal of, Handbook of Analytical Separations. [9] G. Pépin, G. Duffort, N. Rommel, P. Kintz, V. Dumestre-Toulet, M.-F, pp.67-390, 1988. ,
Passer ?? travers les tests de d??pistage : substitution, dilution, adult??ration des urines et des cheveux, Annales de Toxicologie Analytique, vol.14, issue.1, p.43, 2002. ,
DOI : 10.1051/ata/2002038
Validation of ELISA screening and LC???MS/MS confirmation methods for cocaine in hair after simple extraction, Analytical and Bioanalytical Chemistry, vol.145, issue.2???3, p.1539, 2010. ,
DOI : 10.1007/s00216-010-3684-x
Using environmental analytical data to estimate levels of community consumption of illicit drugs and abused pharmaceuticals, Journal of Environmental Monitoring, vol.142, issue.7, p.701, 2007. ,
DOI : 10.1039/b702799k
Water Analysis: Emerging Contaminants and Current Issues, Analytical Chemistry, vol.81, issue.12, p.4645, 2009. ,
DOI : 10.1021/ac9008012
HPLC???DAD determination of opioids, cocaine and their metabolites in plasma, Forensic Science International, vol.161, issue.1, p.31, 2006. ,
DOI : 10.1016/j.forsciint.2005.10.016
Determination of basic drugs of abuse in human serum by online extraction and LC???MS/MS, Analytical and Bioanalytical Chemistry, vol.71, issue.8, p.2499, 2009. ,
DOI : 10.1007/s00216-009-3036-x
Determination of 19 drugs of abuse and metabolites in whole blood by high-performance liquid chromatography???tandem mass spectrometry, Analytical and Bioanalytical Chemistry, vol.35, issue.7, p.2393, 2010. ,
DOI : 10.1007/s00216-009-3268-9
Determination of opiates and cocaine in urine by high pH mobile phase reversed phase UPLC???MS/MS, Journal of Chromatography B, vol.877, issue.4, p.421, 2009. ,
DOI : 10.1016/j.jchromb.2008.12.052
VALIDATED QUANTITATIVE SIMULTANEOUS DETERMINATION OF COCAINE, OPIATES AND AMPHETAMINES IN SERUM BY U-HPLC COUPLED TO TANDEM MASS SPECTROMETRY, Acta Clinica Belgica, vol.36, issue.1, p.75, 2010. ,
DOI : 10.1016/j.chroma.2007.03.111
A high???throughput multicomponent screening method for diuretics, masking agents, central nervous system (CNS) stimulants and opiates in human urine by UPLC???MS/MS, Journal of Mass Spectrometry, vol.75, issue.7, p.980, 2008. ,
DOI : 10.1002/jms.1436
ELISA and HPLC analysis of ochratoxin A in red wines of Croatia, Food Control, vol.20, issue.6, p.590, 2009. ,
DOI : 10.1016/j.foodcont.2008.08.021
Natural Occurrence of Ochratoxin A and Antioxidant Activities of Green and Roasted Coffees and Corresponding Byproducts, Journal of Agricultural and Food Chemistry, vol.55, issue.25, p.10499, 2007. ,
DOI : 10.1021/jf071959+
Evaluation of Methods Used To Determine Ochratoxin A in Coffee Beans, Journal of Agricultural and Food Chemistry, vol.55, issue.23, p.9576, 2007. ,
DOI : 10.1021/jf072558x
External and internal dose in subjects occupationally exposed to ochratoxin A, International Archives of Occupational and Environmental Health, vol.75, issue.6, p.381, 2002. ,
DOI : 10.1007/s00420-002-0319-3
Preliminary study of Ochratoxin A in human plasma in agricultural zones of Chile and its relation to food consumption, Food and Chemical Toxicology, vol.44, issue.11, p.1884, 2006. ,
DOI : 10.1016/j.fct.2006.06.008
In Vitro Cytogenetic Results Supporting a DNA Nonreactive Mechanism for Ochratoxin A, Potentially Relevant for Its Carcinogenicity, Chemical Research in Toxicology, vol.21, issue.6, p.1235, 2008. ,
DOI : 10.1021/tx800029f
Chromatographic methods for the determination of ochratoxin A in animal and human tissues and fluids, Journal of Chromatography A, vol.815, issue.1, p.75, 1998. ,
DOI : 10.1016/S0021-9673(98)00163-0
Occurrence of aflatoxin B1, citrinin and ochratoxin A in rice in five provinces of the central region of Vietnam, Food Chemistry, vol.105, issue.1, p.42, 2007. ,
DOI : 10.1016/j.foodchem.2007.03.040
The occurrence of ochratoxin A in coffee, Food and Chemical Toxicology, vol.33, issue.5, p.341, 1995. ,
DOI : 10.1016/0278-6915(94)00150-M
Simple and high-throughput method for the multimycotoxin analysis in cereals and related foods by ultra-high performance liquid chromatography/tandem mass spectrometry, Food Chemistry, vol.117, issue.4, p.705, 2009. ,
DOI : 10.1016/j.foodchem.2009.04.045
Ultra-performance liquid chromatography/tandem mass spectrometry for the simultaneous analysis of aflatoxins B1, G1, B2, G2 and ochratoxin A in beer, Rapid Communications in Mass Spectrometry, vol.13, issue.21, p.3199, 2006. ,
DOI : 10.1002/rcm.2723
The Gilson Guide for SPE automation ,
Recent developments in extraction procedures relevant to analytical toxicology, Analytical and Bioanalytical Chemistry, vol.801, issue.7, p.1381, 2007. ,
DOI : 10.1007/s00216-007-1294-z
Matrix effects in quantitative pesticide analysis using liquid chromatography???mass spectrometry, Mass Spectrometry Reviews, vol.378, issue.6, p.881, 2006. ,
DOI : 10.1002/mas.20097
Determination of drugs of abuse in blood, Journal of Chromatography B: Biomedical Sciences and Applications, vol.713, issue.1, p.91, 1998. ,
DOI : 10.1016/S0378-4347(97)00573-2
An Aptamer Cross-Linked Hydrogel as a Colorimetric Platform for Visual Detection, Angewandte Chemie International Edition, vol.48, issue.6, p.1052, 2010. ,
DOI : 10.1002/anie.200905570
Label-free impedimetric immunosensor for sensitive detection of ochratoxin A, Biosensors and Bioelectronics, vol.24, issue.7, p.1888, 2009. ,
DOI : 10.1016/j.bios.2008.09.021
An electrochemical immunosensor for ochratoxin A based on immobilization of antibodies on diazonium-functionalized gold electrode, Electrochimica Acta, vol.54, issue.8, p.2180, 2009. ,
DOI : 10.1016/j.electacta.2008.10.013
Novel highly-performing immunosensor-based strategy for ochratoxin A detection in wine samples, Biosensors and Bioelectronics, vol.23, issue.7, p.995, 2008. ,
DOI : 10.1016/j.bios.2007.10.002
Development of immunosensor based on OWLS technique for determining Aflatoxin B1 and Ochratoxin A, Biosensors and Bioelectronics, vol.22, issue.6, p.797, 2007. ,
DOI : 10.1016/j.bios.2006.02.015
Emerging biotools for assessment of mycotoxins in the past decade, TrAC Trends in Analytical Chemistry, vol.26, issue.7, p.689, 2007. ,
DOI : 10.1016/j.trac.2007.05.012
Continuous, Real-Time Monitoring of Cocaine in Undiluted Blood Serum via a Microfluidic, Electrochemical Aptamer-Based Sensor, Journal of the American Chemical Society, vol.131, issue.12, p.4262, 2009. ,
DOI : 10.1021/ja806531z
29. [113] N. Delaunay-Bertoncini, Thèse intutilée "Développement d'immunoadsorbants à base d'anticorps monoclonaux pour l'extraction sélective de familles de micropolluants organiques, Journal of Chromatography, A, vol.1000, 2001. ,
URL : https://hal.archives-ouvertes.fr/hal-00842185
Selective sample treatment using molecularly imprinted polymers, Journal of Chromatography A, vol.1152, issue.1-2, p.41, 2007. ,
DOI : 10.1016/j.chroma.2007.02.109
URL : https://hal.archives-ouvertes.fr/hal-00261614
Retention mechanism of analytes in the solid-phase extraction process using molecularly imprinted polymers, Journal of Chromatography B, vol.804, issue.1, p.93, 2004. ,
DOI : 10.1016/j.jchromb.2003.12.033
Towards ochratoxin A selective molecularly imprinted polymers for solid-phase extraction, Journal of Chromatography A, vol.945, issue.1-2, p.45, 2002. ,
DOI : 10.1016/S0021-9673(01)01504-7
Adaptation of the molecular imprinted polymers towards polar environment, Analytica Chimica Acta, vol.542, issue.1, p.47, 2005. ,
DOI : 10.1016/j.aca.2005.01.034
The Aptamer Handbook, p.228, 2006. ,
Aptamères énantiosélectifs en série ADN et ARN : applications à la séparation chirale en microchromatographie et en électrophorèse capillaire, 2008. ,
Structural Basis of Ligand Discrimination by Two Related RNA Aptamers Resolved by NMR Spectroscopy, Science, vol.272, issue.5266, p.1343, 1996. ,
DOI : 10.1126/science.272.5266.1343
High-resolution molecular discrimination by RNA, Science, vol.263, issue.5152, p.1425, 1994. ,
DOI : 10.1126/science.7510417
Isolation of RNA Aptamers for Biological Cofactors by In Vitro Selection, Angewandte Chemie International Edition in English, vol.30, issue.10, p.1084, 1994. ,
DOI : 10.1002/anie.199410841
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase, Science, vol.249, issue.4968, p.505, 1990. ,
DOI : 10.1126/science.2200121
Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase, PLoS Biology, vol.261, issue.4, p.123, 2005. ,
DOI : 10.1371/journal.pbio.0030123.g006
URL : https://hal.archives-ouvertes.fr/cea-00161297
Development of an automated in vitro selection protocol to obtain RNA-based aptamers: identification of a biostable substance P antagonist, Nucleic Acids Research, vol.33, issue.4, p.45, 2005. ,
DOI : 10.1093/nar/gni044
Integrated microfluidic system for rapid screening of CRP aptamers utilizing systematic evolution of ligands by exponential enrichment (SELEX), Biosensors and Bioelectronics, vol.25, issue.7, p.1761, 2010. ,
DOI : 10.1016/j.bios.2009.12.029
SELEX???A (r)evolutionary method to generate high-affinity nucleic acid ligands, Biomolecular Engineering, vol.24, issue.4, p.381, 2007. ,
DOI : 10.1016/j.bioeng.2007.06.001
An RNA aptamer to the xanthine/guanine base with a distinctive mode of purine recognition, Nucleic Acids Research, vol.26, issue.7, p.1755, 1998. ,
DOI : 10.1093/nar/26.7.1755
Determination of Ochratoxin A with a DNA Aptamer, Journal of Agricultural and Food Chemistry, vol.56, issue.22, p.10456, 2008. ,
DOI : 10.1021/jf801957h
Aptamer-Based Folding Fluorescent Sensor for Cocaine, Journal of the American Chemical Society, vol.123, issue.21, p.4928, 2001. ,
DOI : 10.1021/ja0038171
Aptamer-Based Colorimetric Probe for Cocaine, Journal of the American Chemical Society, vol.124, issue.33, p.9678, 2002. ,
DOI : 10.1021/ja0259483
RNA aptamers that bind L-arginine with sub-micromolar dissociation constants and high enantioselectivity, Nucleic Acids Research, vol.24, issue.6, p.1029, 1996. ,
DOI : 10.1093/nar/24.6.1029
URL : http://doi.org/10.1093/nar/24.6.1029
DNA Aptamers Selected Against the HIV-1trans-Activation-responsive RNA Element Form RNA-DNA Kissing Complexes, Journal of Biological Chemistry, vol.274, issue.18, p.12730, 1999. ,
DOI : 10.1074/jbc.274.18.12730
Molecular Recognition of Amino Acids by RNA-Aptamers: An L-Citrulline Binding RNA Motif and Its Evolution into an L-Arginine Binder, Journal of the American Chemical Society, vol.116, issue.5, p.1698, 1994. ,
DOI : 10.1021/ja00084a010
Nanomechanical microcantilever operated in vibration modes with use of RNA aptamer as receptor molecules for label-free detection of HCV helicase, Biosensors and Bioelectronics, vol.23, issue.4, p.459, 2007. ,
DOI : 10.1016/j.bios.2007.05.006
The DNA aptamers that specifically recognize ricin toxin are selected by twoin vitro selection methods, ELECTROPHORESIS, vol.13, issue.7, p.1303, 2006. ,
DOI : 10.1002/elps.200500489
In Vitro Selection of Functional Nucleic Acids, Annual Review of Biochemistry, vol.68, issue.1, p.611, 1999. ,
DOI : 10.1146/annurev.biochem.68.1.611
Biosensor-based on-site explosives detection using aptamers as recognition elements, Analytical and Bioanalytical Chemistry, vol.14, issue.2, p.1793, 2008. ,
DOI : 10.1007/s00216-008-2150-5
Specific binding of aminoglycoside antibiotics to RNA, Chemistry & Biology, vol.2, issue.5, p.281, 1995. ,
DOI : 10.1016/1074-5521(95)90047-0
Fluorescent Sensors Based on Aptamer Self-Assembly, Journal of the American Chemical Society, vol.122, issue.46, p.11547, 2000. ,
DOI : 10.1021/ja0022223
The aptamer Handbook, p.280, 2006. ,
Aptamers against extracellular targets for in vivo applications, Biochimie, vol.87, issue.9-10, p.921, 2005. ,
DOI : 10.1016/j.biochi.2005.04.013
Protein Detection with Aptamer Biosensors, Sensors, vol.8, issue.7, p.4296, 2008. ,
DOI : 10.3390/s8074296
Electrogenerated chemiluminescence aptamer-based biosensor for the determination of cocaine, Electrochemistry Communications, vol.9, issue.10, p.2571, 2007. ,
DOI : 10.1016/j.elecom.2007.07.038
Electrochemical, Photoelectrochemical, and Surface Plasmon Resonance Detection of Cocaine Using Supramolecular Aptamer Complexes and Metallic or Semiconductor Nanoparticles, Analytical Chemistry, vol.81, issue.22, p.9291, 2009. ,
DOI : 10.1021/ac901551q
Single Quantum-Dot-Based Aptameric Nanosensor for Cocaine, Analytical Chemistry, vol.81, issue.8, p.3051, 2009. ,
DOI : 10.1021/ac802737b
Adenosine detection by using gold nanoparticles and designed aptamer sequences, The Analyst, vol.289, issue.7, p.1355, 2009. ,
DOI : 10.1039/b900900k
Fast Colorimetric Sensing of Adenosine and Cocaine Based on a General Sensor Design Involving Aptamers and Nanoparticles, Angewandte Chemie International Edition, vol.42, issue.1, p.90, 2006. ,
DOI : 10.1002/anie.200502589
Detection of aptamer???protein interactions using QCM and electrochemical indicator methods, Bioorganic & Medicinal Chemistry Letters, vol.15, issue.2, p.291, 2005. ,
DOI : 10.1016/j.bmcl.2004.10.083
Quantum-Dot Aptamer Beacons for the Detection of Proteins, ChemBioChem, vol.95, issue.12, pp.2163-183, 2005. ,
DOI : 10.1002/cbic.200500218
A Simple and Sensitive ???Dipstick??? Test in Serum Based on Lateral Flow Separation of Aptamer-Linked Nanostructures, Angewandte Chemie International Edition, vol.1, issue.47, p.7955, 2006. ,
DOI : 10.1002/anie.200603106
Aptamers as Ligands in Affinity Probe Capillary Electrophoresis, Analytical Chemistry, vol.70, issue.21, p.4540, 1998. ,
DOI : 10.1021/ac980638h
Different strategies to develop an electrochemical thrombin aptasensor, Electrochemistry Communications, vol.8, issue.3, p.505, 2006. ,
DOI : 10.1016/j.elecom.2005.12.022
Nucleic Acid-Functionalized Pt Nanoparticles:?? Catalytic Labels for the Amplified Electrochemical Detection of Biomolecules, Analytical Chemistry, vol.78, issue.7, p.2268, 2006. ,
DOI : 10.1021/ac0519864
Detection of Protein Biomarkers Using RNA Aptamer Microarrays and Enzymatically Amplified Surface Plasmon Resonance Imaging, Analytical Chemistry, vol.79, issue.3, p.1082, 2007. ,
DOI : 10.1021/ac061849m
Competitive Binding Assay for Thyroxine Using in Vitro Selected Oligonucleotides, Analytical Chemistry, vol.70, issue.16, p.3510, 1998. ,
DOI : 10.1021/ac9800816
An enzyme-linked oligonucleotide assay, Nature Biotechnology, vol.92, issue.8, p.1021, 1996. ,
DOI : 10.1016/1074-5521(95)90032-2
Aptamers: molecular tools for analytical applications, Analytical and Bioanalytical Chemistry, vol.5, issue.9, p.989, 2008. ,
DOI : 10.1007/s00216-007-1346-4
Analytical applications of aptamers, Biosensors and Bioelectronics, vol.20, issue.12, p.2424, 2005. ,
DOI : 10.1016/j.bios.2004.11.006
Aptamers as analytical reagents, ELECTROPHORESIS, vol.40, issue.9, p.1335, 2002. ,
DOI : 10.1002/1522-2683(200205)23:9<1335::AID-ELPS1335>3.0.CO;2-E
Retention and Separation of Adenosine and Analogues by Affinity Chromatography with an Aptamer Stationary Phase, Analytical Chemistry, vol.73, issue.22, p.5415, 2001. ,
DOI : 10.1021/ac0105437
Covalently bonded DNA aptamer chiral stationary phase for the chromatographic resolution of adenosine, Analytical and Bioanalytical Chemistry, vol.21, issue.4, p.1051, 2008. ,
DOI : 10.1007/s00216-007-1552-0
URL : https://hal.archives-ouvertes.fr/hal-00383152
Quantitation of cocaine and cocaethylene in small volumes of rat whole blood using gas chromatography-mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, vol.15, issue.8, p.1167, 1997. ,
DOI : 10.1016/S0731-7085(96)01952-8
Aptamer-Based Affinity Chromatographic Assays for Thrombin, Analytical Chemistry, vol.80, issue.19, p.7586, 2008. ,
DOI : 10.1021/ac801206s
Analysis of Adenosine Triphosphate and Glutathione through Gold Nanoparticles Assisted Laser Desorption/Ionization Mass Spectrometry, Analytical Chemistry, vol.79, issue.13, p.4852, 2007. ,
DOI : 10.1021/ac070023x
An aptamer-based microfluidic device for thermally controlled affinity extraction, Microfluidics and Nanofluidics, vol.94, issue.4, p.479, 2009. ,
DOI : 10.1007/s10404-008-0322-4
Solid-State Sensors, Actuators and Microsystems Conference, International, p.1857, 2007. ,
Nucleic acid aptamer molecular recognition principles and application in liquid chromatography and capillary electrophoresis, Journal of Separation Science, vol.33, issue.10, p.1531, 2009. ,
DOI : 10.1002/jssc.200900061
URL : https://hal.archives-ouvertes.fr/hal-00383198
Covalent attachment of synthetic DNA to self-assembled monolayer films, Nucleic Acids Research, vol.24, issue.15, p.3031, 1996. ,
DOI : 10.1093/nar/24.15.3031
Evaluation of various immobilized enzymatic microreactors coupled on-line with liquid chromatography and mass spectrometry detection for quantitative analysis of cytochrome c, Journal of Chromatography A, vol.1209, issue.1-2, p.95, 2008. ,
DOI : 10.1016/j.chroma.2008.08.120
Bonded stationary phases in chromatography, 1974. ,
Pierce application notes AN0014, 2006. ,
An Aptamer Cross-Linked Hydrogel as a Colorimetric Platform for Visual Detection, Angewandte Chemie International Edition, vol.48, issue.6, p.1052, 2010. ,
DOI : 10.1002/anie.200905570
The analysis of drugs in biological fluids, p.39, 1995. ,
Comparison of protein precipitation methods for sample preparation prior to proteomic analysis, Journal of Chromatography A, vol.1023, issue.2, p.317, 2004. ,
DOI : 10.1016/j.chroma.2003.10.029
Protein precipitation for the analysis of a drug cocktail in plasma by LC???ESI???MS, Journal of Pharmaceutical and Biomedical Analysis, vol.35, issue.4, p.913, 2004. ,
DOI : 10.1016/j.jpba.2004.03.005