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Theses

Pervaporation microfluidique pour le criblage et mesures de concentration in situ

Abstract : This thesis presents the design and implementation of a microfluidic device in PDMS (Polydimethylsiloxane) for the exploration of phase diagrams. The microsystem uses pervaporation (evaporation through a membrane). It includes independent microchambres 5nL solution which concentration changes over time. It is possible to concentrate up to the observation of phase transitions (demixing, nucleation, crystallization, ...). We have shown that pervaporation is an interesting method for phase diagram explorations. In parallel, we developed an original tool for in situ and in real time concentration measurements, which is the fundamental screening parameter. This tool, based on the principle of refractometry, has the advantage of being non-intrusive and requires no special modification of the microsystem. The method uses the microchannel walls as optical elements. We show that this method allows to measure diffusion coefficients and viscosities in T-junctions without adding tracers nor use fluorescence. We used this method for measuring in situ concentration in screening experiments using model fluid systems (ionic solutions, surfactants, polymers, proteins, ...).
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Submitted on : Thursday, January 13, 2011 - 4:39:59 PM
Last modification on : Saturday, September 26, 2020 - 11:44:08 PM
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  • HAL Id : pastel-00555545, version 1

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Annick Marin. Pervaporation microfluidique pour le criblage et mesures de concentration in situ. Dynamique des Fluides [physics.flu-dyn]. Université Pierre et Marie Curie - Paris VI, 2009. Français. ⟨pastel-00555545⟩

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