Etude des Propriétés Viscoélastiques des Tissus Mous par Elastographie IRM. Une Approche Multi-Echelle

Abstract : Ultrasound andMRI elastography has developed rapidly these past days in order to estimate the viscoelastic properties of soft tissues. This new diagnostic tool is particularly adapted to characterize pathologies such as breast carcinoma because of its higher elasticity than the surrounding tissue. In the first part of the manuscript, viscoelasticmedia are presented in order to describe their mechanical behaviors while an elastic wave is generated. Several rheological models are introduced and analyzed to find the more adapted description of the mechanical properties of soft tissues estimated out of MR-Elastography acquisitions. The second part presents the different techniques of ultrasound elastography and the basis of the Magnetic Resonance Imaging in order to better understand the objectives of MR-Elastography. Two MR-Elastography sequences are theoretically and experimentally analyzed in order to optimize the quality of mechanical properties estimation. The third part enlightens the difficulties to adapt current MR-Elastography sequences to short T2* tissues such as the carotid or the heart. Thus, a new sequence is introduced : the DENSE-MRE sequence. This new MRI sequence is theoretically and experimentally compared to conventional MR-Elastography sequences. And this new sequence is is used in vivo to estimate elastograms of heart during the heart cycle.
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Benjamin Robert. Etude des Propriétés Viscoélastiques des Tissus Mous par Elastographie IRM. Une Approche Multi-Echelle. Optique [physics.optics]. Université Paris-Diderot - Paris VII, 2009. Français. ⟨pastel-00556732⟩

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