. Es-besitzt-einen-penetranten, höchst unangenehmen Geruch ; das Öffnen eines Gefäßes mit Cyanallyl reicht hin, die Luft eines Zimmers mehrere Tage lang zu verpesten, weshalb alle Arbeiten mit demselben im Freien vorgenommen werden müssen

A. , L. Ann, and . Chem, Gautier A. Liebigs Ann, et 155-161. Gautier A. Liebigs Ann, pp.289-294, 1867.

T. Shingaki, M. Takebayashi, and . Bull, Reaction of Dichlorocarbene and Primary Amines???preparation of Aromatic Isocyanides, Bulletin of the Chemical Society of Japan, vol.36, issue.5, pp.617-617, 1963.
DOI : 10.1246/bcsj.36.617

A. W. Hofmann, . Acad, and A. P. Sci-krapcho, Organic Syntheses, Coll. J. Org. Chem, vol.65, issue.27, pp.484-1089, 1867.

I. Ugi, W. Betz, U. Fetzer, and K. Offermann, Notiz zur Darstellung von Isonitrilen aus monosubstituierten Formamiden durch Wasserabspaltung mittels Phosgen und Trialkylaminen, Chemische Berichte, vol.39, issue.10, pp.2814-2816, 1961.
DOI : 10.1002/cber.19610941033

I. Ugi and R. Meyr, Isonitrile, I. Darstellung von Isonitrilen aus monosubstituierten Formamiden durch Wasserabspaltung, Chemische Berichte, vol.79, issue.1, pp.239-248, 1960.
DOI : 10.1002/cber.19600930136

A. Porcheddu, G. Giacomelli, and M. Salaris, Microwave-Assisted Synthesis of Isonitriles:?? A General Simple Methodology, The Journal of Organic Chemistry, vol.70, issue.6, pp.2361-2363, 2005.
DOI : 10.1021/jo047924f

G. M. Atkins and E. M. Burgess, The reactions of an N-sulfonylamine inner salt, Journal of the American Chemical Society, vol.90, issue.17, pp.4744-4745, 1968.
DOI : 10.1021/ja01019a052

J. Zhu, X. Wu, and S. J. Danishefsky, On the preparation of enantiomerically pure isonitriles from amino acid esters and peptides, Tetrahedron Letters, vol.50, issue.5, pp.577-579, 2009.
DOI : 10.1016/j.tetlet.2008.11.069

H. Lindemann, L. Wiegrebe, and . Ber, ??ber die Konstitution der Verbindungen mit ???zweiwertigem?????? Kohlenstoff, Berichte der deutschen chemischen Gesellschaft (A and B Series), vol.32, issue.7, pp.1650-1657, 1930.
DOI : 10.1002/cber.19300630705

V. V. Tumanov, A. A. Tishkov, and H. Mayr, Nucleophilicity Parameters for Alkyl and Aryl Isocyanides, Angewandte Chemie International Edition, vol.44, issue.19, pp.3563-3566, 2007.
DOI : 10.1002/anie.200605205

A. Dömling, I. Ugi, and L. Grimaud, Multicomponent Reactions with Isocyanides, Angewandte Chemie, vol.7, issue.6, pp.3168-3210, 2000.
DOI : 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U

M. P. Periasamy and H. M. Walborsky, Isocyanides. Dissociation of metallo aldimines, The Journal of Organic Chemistry, vol.39, issue.5, pp.611-618, 1974.
DOI : 10.1021/jo00919a007

N. Elders, R. F. Schmitz, F. J. De-kanter, E. Ruitjer, M. B. Groen et al., A Resource-Efficient and Highly Flexible Procedure for a Three-Component Synthesis of 2-Imidazolines, The Journal of Organic Chemistry, vol.72, issue.16, pp.6135-6142, 2007.
DOI : 10.1021/jo070840x

N. Elders, E. Ruitjer, F. J. De-kanter, M. B. Groen, and R. V. Orru, Selective Formation of 2-Imidazolines and 2-Substituted Oxazoles by Using a Three-Component Reaction, Chemistry - A European Journal, vol.9, issue.16, pp.4961-4973, 2008.
DOI : 10.1002/chem.200800271

D. H. Shaw and H. Pritchard, Free-radical-catalyzed isomerization of isocyanides, Canadian Journal of Chemistry, vol.45, issue.22, pp.2749-2754, 1967.
DOI : 10.1139/v67-445

T. Saegusa, S. Kobayashi, I. Yoshihiko, N. Yasuda, T. Saegusa et al., Radical reaction of isocyanide with organotin hydride, Journal of the American Chemical Society, vol.90, issue.15, pp.4182-4182, 1968.
DOI : 10.1021/ja01017a061

C. Blackburn, B. Guan, P. Fleming, K. Shiosaki, and S. Tsai, Parallel synthesis of 3-aminoimidazo[1,2-a]pyridines and pyrazines by a new three-component condensation, Tetrahedron Letters, vol.39, issue.22, pp.3635-3638, 1998.
DOI : 10.1016/S0040-4039(98)00653-4

S. M. Ireland, H. Tye, and M. Whittaker, Microwave-assisted multi-component synthesis of fused 3-aminoimidazoles, Tetrahedron Letters, vol.44, issue.23, pp.4369-4371, 2003.
DOI : 10.1016/S0040-4039(03)00941-9

Y. Huang, X. Hu, D. Shen, and Y. Chen, Synthesis of 1H-imidazo[1,2-b]-1,2,4-triazol-6-amines via multicomponent reaction, Molecular Diversity, vol.60, issue.2, pp.73-80, 2007.
DOI : 10.1007/s11030-007-9059-3

G. Mandair, M. Light, A. Russell, M. Hursthouse, and M. Bradley, Re-evaluation of the outcome of a multiple component reaction???2- and 3-amino-imidazo[1,2-a]pyrimidines?, Tetrahedron Letters, vol.43, issue.23, pp.4267-4269, 2002.
DOI : 10.1016/S0040-4039(02)00709-8

V. Z. Parchinsky, O. Schuvalova, O. Ushakova, D. V. Kravchenko, and M. Krasavin, Multi-component reactions between 2-aminopyrimidine, aldehydes and isonitriles: the use of a nonpolar solvent suppresses formation of multiple products, Tetrahedron Letters, vol.47, issue.6, pp.947-951, 2006.
DOI : 10.1016/j.tetlet.2005.11.152

S. Carballares, M. M. Cifuentes, and G. A. Stephenson, Regioselective two step synthesis of 3-substituted 2-aminoimidazo[1,2-a]pyrimidines, Tetrahedron Letters, vol.48, issue.11, pp.2041-2045, 2007.
DOI : 10.1016/j.tetlet.2006.11.181

V. Z. Parchinsky, V. V. Koleda, O. Schuvalova, D. V. Kravchenko, and M. Krasavin, Air-oxidized products of multi-component reactions between 3-amino-1,2,4-triazole, aromatic aldehydes and isonitriles, Tetrahedron Letters, vol.47, issue.38, pp.6891-6894, 2006.
DOI : 10.1016/j.tetlet.2006.07.037

M. Adib, M. Mahdavi, M. A. Noghani, and P. Mirzaei, Catalyst-free three-component reaction between 2-aminopyridines (or 2-aminothiazoles), aldehydes, and isocyanides in water, Tetrahedron Letters, vol.48, issue.41, pp.7263-7265, 2007.
DOI : 10.1016/j.tetlet.2007.08.049

A. Shaabani, E. Soleimani, and A. Maleki, Ionic liquid promoted one-pot synthesis of 3-aminoimidazo[1,2-a]pyridines, Tetrahedron Letters, vol.47, issue.18, pp.3031-3034, 2006.
DOI : 10.1016/j.tetlet.2006.03.011

R. S. Varma and D. Kumar, Microwave-accelerated three-component condensation reaction on clay: solvent-free synthesis of imidazo[1,2-a] annulated pyridines, pyrazines and pyrimidines, Tetrahedron Letters, vol.40, issue.43, pp.7665-7669, 1999.
DOI : 10.1016/S0040-4039(99)01585-3

J. J. Chen, A. Golebiowski, J. Mcclenaghan, S. R. Klopfenstein, and L. West, Universal Rink???isonitrile resin: application for the traceless synthesis of 3-acylamino imidazo[1,2-a]pyridines, Tetrahedron Letters, vol.42, issue.12, pp.2269-2271, 2001.
DOI : 10.1016/S0040-4039(01)00159-9

A. Shaabani, F. Rezazadeh, and E. Soleimani, Ammonium chloride catalyzed one-pot synthesis of imidazo[1,2-a]pyridines, Monatshefte f??r Chemie - Chemical Monthly, vol.138, issue.8, pp.931-933, 2008.
DOI : 10.1007/s00706-008-0872-x

D. Bonne, M. Dekhane, J. Zhu, P. Janvier, X. Sun et al., Modulating the Reactivity of ??-Isocyanoacetates: Multicomponent Synthesis of 5-Methoxyoxazoles and Furopyrrolones, Angewandte Chemie International Edition, vol.143, issue.14, pp.2485-2488, 2002.
DOI : 10.1002/anie.200605005
URL : https://hal.archives-ouvertes.fr/hal-00157605

L. Kaim, M. Gizzi, and M. Grimaud, New MCR???Heck???Isomerization Cascade toward Indoles, Organic Letters, vol.10, issue.16, pp.3417-3419, 2008.
DOI : 10.1021/ol801217a

L. Kaim, M. Gizzi, L. Grimaud, and J. Oble, Ugi-Smiles Access to Quinoxaline Derivatives, HETEROCYCLES, vol.73, issue.1, pp.503-517, 2007.
DOI : 10.3987/COM-07-S(U)26

L. Kaim, L. Grimaud, and J. Oble, New Ugi-Smiles-Metathesis Strategy toward the Synthesis of Pyrimido Azepines, The Journal of Organic Chemistry, vol.72, issue.15, pp.5835-5838, 2007.
DOI : 10.1021/jo070706c

P. J. Scheuer, Isocyanides and cyanides as natural products, Accounts of Chemical Research, vol.25, issue.10, pp.433-439, 1992.
DOI : 10.1021/ar00022a001

A. Guirado, A. Zapata, J. L. Gómez, L. Trabalón, and J. Gálvez, Electrochemical generation of alkyl and aryl isocyanides, Tetrahedron, vol.55, issue.31, pp.9631-9640, 1992.
DOI : 10.1016/S0040-4020(99)00509-8

G. Höfle, B. Lange, U. Hess, H. Brosig, and W. P. Fehlhammer, Oxidation of 5-Aminotetraazoles, a New Route to Isocyanides, Angewandte Chemie International Edition in English, vol.18, issue.2, pp.113-114, 1976.
DOI : 10.1002/anie.197601131

M. C. Pirrung and S. Ghorai, Versatile, Fragrant, Convertible Isonitriles, Journal of the American Chemical Society, vol.128, issue.36, pp.11772-11773, 2006.
DOI : 10.1021/ja0644374

W. Madelung, M. Tencer, and . Ber, ??ber einige Reaktionen des Indols, Berichte der deutschen chemischen Gesellschaft, vol.17, issue.1, pp.953-955, 1915.
DOI : 10.1002/cber.191504801129

K. Gollnick, S. Koegler, and D. Maurer, Photooxygenation of 1,4-diaza-1,3-butadienes (.alpha.-diimines): formation of isonitriles, The Journal of Organic Chemistry, vol.57, issue.1, pp.229-234, 1992.
DOI : 10.1021/jo00027a041

T. Mukaijama, K. Tonooka, and K. Inoue, Studies on the Beckmann Rearrangement. I. Dehydrations of Aldoximes with Methylketene Diethylacetal, The Journal of Organic Chemistry, vol.26, issue.7, pp.2202-2206, 1961.
DOI : 10.1021/jo01351a010

H. Bienaymé, ???Reagent explosion???: an efficient method to increase library size and diversity, Tetrahedron Letters, vol.39, issue.24, pp.4255-4258, 1998.
DOI : 10.1016/S0040-4039(98)00696-0

A. Dömling, B. Beck, T. Fuchs, and A. Yazbak, Parallel Synthesis of Arrays of Amino-Acid-Derived Isocyanoamides Useful As Starting Materials in IMCR, Journal of Combinatorial Chemistry, vol.8, issue.6, pp.872-880, 2006.
DOI : 10.1021/cc060068w

P. A. Tempest, D. Brown, and R. W. Armstrong, Solid-Phase, Parallel Syntheses by Ugi Multicomponent Condensation, Angewandte Chemie International Edition in English, vol.35, issue.6, pp.640-642, 1996.
DOI : 10.1002/anie.199606401

T. Austad, J. Songstad, and L. J. Stangeland, The Ambident Nature of the Cyanide Ion. The Reaction between Trityl Chloride and Tetraphenylarsonium Cyanide in Acetonitrile., Acta Chemica Scandinavica, vol.25, pp.2327-2336, 1971.
DOI : 10.3891/acta.chem.scand.25-2327

S. Otsuka, K. Mori, and K. Yamagami, Coordination Effects in Organic Reactions. I. A Novel Preparation of t-Alkyl Isocyanide Complexes by N-Alkylation of Hydrogen Cyanide, The Journal of Organic Chemistry, vol.31, issue.12, pp.4170-4174, 1966.
DOI : 10.1021/jo01350a069

A. Gautier and . Ann, Chimie, 1869, pp.103-203

J. Wade, CLX.???The constitution of the metallic cyanides as deduced from their synthetic interactions: the constitution of hydrogen cyanide, J. Chem. Soc., Trans., vol.81, issue.0, pp.1596-1619, 1902.
DOI : 10.1039/CT9028101596

J. C. Carretero, J. L. García-ruano, G. Höfle, and B. Lange, Stereochemistry of the reactions of ??-halothioethers with NaCN and AgCN, Tetrahedron Letters, vol.26, issue.28, pp.3381-3384, 1985.
DOI : 10.1016/S0040-4039(00)98303-5

K. Imi, N. Yanagihara, K. Utimoto, P. G. Gassman, T. L. Guggenheim et al., Reaction of cyanotrimethylsilane with oxiranes. Effects of catalysts or mediators on regioselectivity and ambident character, The Journal of Organic Chemistry, vol.52, issue.6, pp.1013-1016, 1987.
DOI : 10.1021/jo00382a008

Y. Kitano, K. Chiba, and M. Tada, A direct conversion of alcohols to isocyanides, Tetrahedron Letters, vol.39, issue.14, pp.1911-1912, 1998.
DOI : 10.1016/S0040-4039(98)00045-8

K. Masutani, T. Minowa, T. Mukaiyama, T. Mukaiyama, and H. Yamabe, Selective Synthesis of Isocyanides from Secondary Alcohols by a New Type of Oxidation???Reduction Condensation, Chemistry Letters, vol.34, issue.8, pp.1124-1125, 2005.
DOI : 10.1246/cl.2005.1124

J. Songstad, L. J. Stangeland, T. Austad, T. Austad, J. Songstad et al., Isonitriles from Alkyl Halides and Onium Dicyanoargentates., Acta Chemica Scandinavica, vol.24, issue.25, pp.355-356, 1970.
DOI : 10.3891/acta.chem.scand.24-0355

W. Weith, J. Ber-casanova, N. D. Werner, and R. E. Schuster, Sung K, Dtsch. Chem. Ges. 1873 J. Org. Chem. J. Org. Chem, vol.6, issue.31, pp.210-214, 1966.

M. Meier, B. Müller, and C. Rüchardt, The isonitrile-nitrile rearrangement. A reaction without a structure-reactivity relationship, The Journal of Organic Chemistry, vol.52, issue.4, pp.648-652, 1987.
DOI : 10.1021/jo00380a028

H. 123-finkelstein, . Ber, and . Dtsch, Darstellung organischer Jodide aus den entsprechenden Bromiden und Chloriden, Berichte der deutschen chemischen Gesellschaft, vol.1870, issue.2, pp.1528-1532, 1910.
DOI : 10.1002/cber.19100430257

M. Li, J. Cheung, and A. Mayr, Syntheses and Solid-State Structures of Molecular and Extended Silver(I) Complexes of 4-Isocyano-3,5-diisopropylbenzonitrile, Journal of Solid State Chemistry, vol.152, issue.1, pp.247-252, 2000.
DOI : 10.1006/jssc.2000.8689

R. S. Bon, B. Vliet, N. E. Sprenkels, R. F. Schmitz, F. Kanter et al., Multicomponent Synthesis of 2-Imidazolines, The Journal of Organic Chemistry, vol.70, issue.9, pp.3542-3553, 2005.
DOI : 10.1021/jo050132g

L. Kaim, L. Grimaud, and J. Oble, Phenol Ugi-Smiles Systems: Strategies for the Multicomponent N-Arylation of Primary Amines with Isocyanides, Aldehydes, and Phenols, Angewandte Chemie International Edition, vol.43, issue.48, pp.7961-7964, 2005.
DOI : 10.1002/anie.200502636
URL : https://hal.archives-ouvertes.fr/hal-00176926

E. Kaim, L. Gizolme, M. Grimaud, L. Oble, and J. , -Arylamides, The Journal of Organic Chemistry, vol.72, issue.11, pp.4169-4180, 2007.
DOI : 10.1021/jo070202e
URL : https://hal.archives-ouvertes.fr/hal-00176916

W. M. Dai and H. Li, Lewis acid-catalyzed formation of Ugi four-component reaction product from Passerini three-component reaction system without an added amine, Tetrahedron, vol.63, issue.52, pp.12866-12876, 2007.
DOI : 10.1016/j.tet.2007.10.050

W. Dai and H. Li, Lewis acid-catalyzed formation of Ugi four-component reaction product from Passerini three-component reaction system without an added amine, Tetrahedron, vol.63, issue.52, pp.12866-12876, 2007.
DOI : 10.1016/j.tet.2007.10.050

M. C. Pirrung and K. D. Sarma, Aqueous medium effects on multi-component reactions, Tetrahedron, vol.61, issue.48, pp.11456-11472, 2005.
DOI : 10.1016/j.tet.2005.08.068

V. Z. Parchinsky, O. Shuvalova, O. Ushakova, D. Kravchenko, and M. Krasavin, Multi-component reactions between 2-aminopyrimidine, aldehydes and isonitriles: the use of a nonpolar solvent suppresses formation of multiple products, Tetrahedron Letters, vol.47, issue.6, pp.947-951, 2006.
DOI : 10.1016/j.tetlet.2005.11.152

A. Trifilenkov, A. Ilyin, V. Kysil, Y. Sandulenko, and A. Ivachtchenko, One-pot tandem complexity-generating reaction based on Ugi four component condensation and intramolecular cyclization, Tetrahedron Letters, vol.48, issue.14, pp.2563-2567, 2007.
DOI : 10.1016/j.tetlet.2007.02.015

E. Kaïm, . Gamez-montaño, . Grimaud, and . Ibarra-rivera, 139 Un mécanisme ionique faisant intervenir un énolate de palladium a été proposé car les produits diffèrent de ceux obtenus avec du triflate de cuivre II via un processus radicalaire. 140 Levy A., Rains H., Smiles S, Chem. Commun. J. Chem. Soc, issue.11, pp.3264-3269, 1350.

R. Bayles, M. Johnson, R. Maisey, and R. Turner, -Aryl-2-hydroxy-2-methylpropanamides, Synthesis, vol.1977, issue.01, pp.31-33
DOI : 10.1055/s-1977-24262
URL : https://hal.archives-ouvertes.fr/hal-01019750

N. Sharma, R. Gupta, M. Kumar, and R. R. Gupta, Synthesis of fluorophenothiazines via Smiles rearrangement and their conversion into sulfones, Journal of Fluorine Chemistry, vol.98, issue.2, pp.153-157, 1999.
DOI : 10.1016/S0022-1139(99)00098-6

M. Soukri, S. Lazar, M. Akssira, and G. Guillaumet, ]pyridine Derivatives, Organic Letters, vol.2, issue.11, pp.1557-1560, 2000.
DOI : 10.1021/ol005761l

S. Davies and W. Hume, Smiles rearrangements promoted by complexation to chromium tricarbonyl, Tetrahedron Letters, vol.36, issue.15, pp.2673-2674, 1995.
DOI : 10.1016/0040-4039(95)00330-F

N. Gilman, P. Levitan, and L. Sternbach, A nitrogen-nitrogen intramolecular aromatic substitution reaction, Tetrahedron Letters, vol.11, issue.47, pp.4121-4124, 1970.
DOI : 10.1016/S0040-4039(01)98682-4

P. Anelli, M. Brocchetta, L. Calabi, C. Secchi, F. Uggeri et al., Smiles rearrangement as a tool for the preparation of 5-[(2-hydroxyacyl)amino]-2,4,6-triiodo-1,3-benzenedicarboxamides: Main pathway and side reactions, Tetrahedron, vol.53, issue.34, pp.11919-11928, 1997.
DOI : 10.1016/S0040-4020(97)00764-3

Y. Fukuzawa, N. Kato, and S. Ito, Phenyl migration in bicyclo[5.3.1]undeca-1,3,5,8-tetraene-8-carboxy-n-methylanilide a unique truce-smiles type rearrangement of an anilide, Tetrahedron Letters, vol.23, issue.4, pp.437-438, 1982.
DOI : 10.1016/S0040-4039(00)86853-7

L. Mitchell and N. Barvian, A homologous enolate Truce???Smiles rearrangement, Tetrahedron Letters, vol.45, issue.29, pp.5669-5672, 2004.
DOI : 10.1016/j.tetlet.2004.05.111

W. Erickson and M. Mckennon, Unexpected Truce???Smiles type rearrangement of 2-(2???-pyridyloxy) phenylacetic esters: synthesis of 3-pyridyl-2-benzofuranones, Tetrahedron Letters, vol.41, issue.23, pp.4541-4544, 2000.
DOI : 10.1016/S0040-4039(00)00701-2

A. Studer and M. Bossart, Radical aryl migration reactions, Tetrahedron, vol.57, issue.48, pp.9649-9667, 2001.
DOI : 10.1016/S0040-4020(01)00990-5

M. Tada, H. Shijima, and M. Nakamura, Smiles-type free radical rearrangement of aromatic sulfonates and sulfonamides: syntheses of arylethanols and arylethylamines, Organic & Biomolecular Chemistry, vol.1, issue.14, pp.2499-2505, 2003.
DOI : 10.1039/b303728b