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Analyse d'images multi-modales TEP-TDM du thorax. Application à l'oncologie : segmentation de tumeurs, d'organes à risque et suivi longitudinal pour la radiothérapie

Abstract : In oncological thoracic imaging, computerized tomography (CT) and positron emission tomography (PET) are widely used jointly, for diagnosis or treatment planing. The development of combined scanners enables the acquisition of pairs of CT-PET volumes, allowing their joint exploitation in clinical routine, without the prerequisite for complex registration. One goal of this thesis work was to propose a segmentation method jointly exploiting PET and CT image information. The proposed methodology therefore focuses on a detailed segmentation of the CT images, using PET information to guide the tumor segmentation. The framework of variational segmentation methods is used to design our algorithms and the specific constraints based on PET information. In addition to target structures for radiotherapy (tumors, nodules), organs at risk which need to be preserved from radiations, must be segmented. An additional goal of this thesis is to provide segmentation methods for these organs. The methods rely on strong a priori knowledge on the non-parametric intensity distributions and on the shapes of the different organs. A final goal of the thesis is to propose a methodological framework for the segmentation of tumors in the context of longitudinal follow up of patients with registered images. The proposed segmentation methods were tested on multiple data sets. When manual tracing is available, quantitive comparisons of the segmentations are presented, demonstrating the performance and accuracy of the proposed segmentation framework.
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https://pastel.archives-ouvertes.fr/pastel-00567100
Contributor : Julien Wojak <>
Submitted on : Friday, February 18, 2011 - 11:01:35 AM
Last modification on : Tuesday, October 20, 2020 - 10:46:51 AM

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Julien Wojak. Analyse d'images multi-modales TEP-TDM du thorax. Application à l'oncologie : segmentation de tumeurs, d'organes à risque et suivi longitudinal pour la radiothérapie. Traitement du signal et de l'image [eess.SP]. Télécom ParisTech, 2010. Français. ⟨pastel-00567100⟩

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