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Theses

Allergénicité des Granules Cytoplasmiques de Pollen

Abstract : Grass pollen is one of the most important aeroallergen vectors in Europe. It highly contributes to respiratory allergic diseases such as asthma or allergic rhinitis. In contact to water or airborne pollutants, pollen grains can release microparticles or pollen cytoplasmic granules. Because of their size (<5 !m), granules may penetrate deeper into the lungs than pollen grains and so, can induce stronger allergic responses. The aim of this study was to characterized allergic potential of pollen cytoplasmic granules along 3 axes: epidemiological, experimental and analytical. Results of the epidemiological study involve a possible effect of granules in the onset of allergic reparatory diseases, in particular asthma. In experimental part, the results show that granules induced allergic - both humoral and cellular - and inflammatory responses. These results are compared with whole pollen, on a good animal model of allergy, the Brown Norway rat. Finally, according to the results of the analytical study, both water-soluble and water-insoluble allergens of granules contribute to the allergenicity of these microparticles.
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Submitted on : Friday, February 18, 2011 - 12:30:48 PM
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  • HAL Id : pastel-00567120, version 1

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Oussama Abou Chakra. Allergénicité des Granules Cytoplasmiques de Pollen. Biologie cellulaire. Université Paris-Diderot - Paris VII, 2009. Français. ⟨pastel-00567120⟩

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