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Etude des gènes de la famille IFF dans les interactions de C. albicans avec son hôte.

Abstract : C. albicans is an opportunistic pathogen responsible for nosocomial candidiasis, and its cell wall is the most important therapeutic target. The principal cell wall protein type is the one composed by the GPI anchored proteins which largest family is composed of the 12 members of the IFF family. Hyr1, an hyphal regulation protein, has been shown to be a virulence factor, moreover, Iff4 is involved in the adherence and Iff11, the only secreted protein in this family, is involved in the cell wall biosynthesis and virulence. We have shown that the expression of this kind of proteins is low under lab conditions as well as in vivo in a mouse model, except HYR1 as expected. The IFF2 gene is highly expressed during stationary phase. The mutant construction did not show the cell wall biosynthesis phenotype, stress response to pH, oxidative stress, high temperature, adherence to epithelial HeLa cells, and survival to macrophages J774. It seems that there is an internal regulation in this protein family regarding IFF2, IFF6, IFF7 and IFF8 on the FF3 and IFF9 genes. Since the production of the homozygous mutants for the IFF3 and IFF9 genes was not possible, with a 99% of similarity, might indicate that this proteins are probably essentials for C. albicans.
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Submitted on : Thursday, June 16, 2011 - 9:56:08 AM
Last modification on : Friday, August 5, 2022 - 2:38:10 PM
Long-term archiving on: : Saturday, September 17, 2011 - 2:21:33 AM


  • HAL Id : pastel-00600903, version 1
  • PRODINRA : 246363



Amandine Cornu. Etude des gènes de la famille IFF dans les interactions de C. albicans avec son hôte.. Biologie moléculaire. AgroParisTech, 2010. Français. ⟨NNT : 2010AGPT0046⟩. ⟨pastel-00600903⟩



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