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Diversité génétique structurale et fonctionnelle du CMH chez le Poulet : Implication pour la résistance aux maladies

Abstract : The major histocompatibility complex (MHC) is a complex genomic region in Vertebrates, still imperfectly known in the chicken and which shows a great genetic variability. The MHC is also an interesting region for studying the genetic determinism of adaptation to pathogens in an evolutionary context. Moreover, the MHC plays a central role in the immune response of an animal to infectious diseases, while a better understanding of the genetic determinism of the immune response against pathogens is important for developing a comprehensive strategy to fight against infectious diseases. We therefore used recent tools of genomics, including genetic markers such as SNPs (Single Nucleotide Polymorphism) to characterize the B region of the chicken MHC. First, genetic diversity has been evaluated in more than 80 breeds or populations with the LEI0258 marker. Then, to cover the entire region using SNP markers, we chose to identify these polymorphisms by resequencing 11 genes of interest and comparing the sequences obtained with the genome sequence and reference sequences available in databases. It also led to the improvement of the knowledge of a number of genes, including three DM-like non-classical class II genes. A 96 SNPs chip, dedicated to the B region of the chicken MHC, has been produced and will soon provide the genotypes of a number of infectious challenge studies conducted at INRA.
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Submitted on : Tuesday, June 21, 2011 - 11:36:01 AM
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  • HAL Id : pastel-00601989, version 1
  • PRODINRA : 246353



Olympe Chazara Trokiner. Diversité génétique structurale et fonctionnelle du CMH chez le Poulet : Implication pour la résistance aux maladies. Génétique animale. AgroParisTech, 2010. Français. ⟨NNT : 2010AGPT0025⟩. ⟨pastel-00601989⟩



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