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Collagène hydrolysé et santé osseuse

Abstract : The osseous diseases related to ageing, such as osteoarthritis or osteoporosis, constitute a true problem of public health. The increase of the bone turn over, and the imbalance between bone formation and resorption, due to the deficiency in estrogens following menopause, contribute to the apparition of osteoporosis. This disease is characterized by a loss of bone mineral density (DMO) and by a degradation of bone microarchitecture which involve an increased risk of fracture. In front of this phenomenon, it is important to develop new products directing toward the promotion of osseous health. Collagen plays an important part in our body, especially on the osseous structure and the cartilage. Consequently it seems interesting to look for the use of collagen or hydrolyzed collagen to limit osseous degeneration. The objective of this study was to demonstrate the beneficial effect of the peptides derived from the intake of hydrolyzed collagen on bone metabolism. We supposed that these peptides mimes the action of the ones issue from the degradation of the type I collagen of the bone matrix on bone cells. We carried out a first experimental approach to check if there could be an effect of hydrolyzed collagen on the bone growth. The cell model used to realize this study is a primary culture of osteoclasts and osteoblasts. We studied cell growth and differenciation. Consequently to this work, we chose a C3H/HeN mouse model which has undergone ovariectomy inducing hormonal deficiency then bone mass density decrease. We followed different bone parameters: DMO, formation and resorption markers, and bone microarchitecture. Our results showed that the intake in a continuous or accurate way of hydrolyzed collagen modulates the osteoblasts activity. This effect induces an increase of the bone turn over formation of the femoral cortical area. This phenomenon induces an increase of bone strength in growing mice or a better bone elasticity in mature mice. Moreover, we noticed a potential effect of hydrolyzed collagen intake to prevent bone lost. Theses results confirm the interest of the intake of hydrolyzed collagen in order to maintain bone health.
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Submitted on : Friday, September 9, 2011 - 3:49:57 PM
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  • HAL Id : pastel-00621193, version 1



Fanny Guillerminet. Collagène hydrolysé et santé osseuse. Alimentation et Nutrition. AgroParisTech, 2010. Français. ⟨NNT : 2010AGPT0059⟩. ⟨pastel-00621193⟩



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