N. Omi and I. Ezawa, The effect of ovariectomy on bone metabolism in rats, Bone, vol.17, issue.4, pp.163-168, 1995.
DOI : 10.1016/8756-3282(95)00329-C

P. Ammann and R. Rizzoli, Bone strength and its determinants, Osteoporosis International, vol.18, issue.S3, pp.13-18, 2003.
DOI : 10.1016/S8756-3282(00)00268-4

D. Burr, The contribution of the organic matrix to bone???s material properties, Bone, vol.31, issue.1, pp.8-11, 2002.
DOI : 10.1016/S8756-3282(02)00815-3

E. Seeman and P. Delmas, Bone Quality ??? The Material and Structural Basis of Bone Strength and Fragility, New England Journal of Medicine, vol.354, issue.21, pp.2250-2261, 2006.
DOI : 10.1056/NEJMra053077

C. Turner, Bone Strength: Current Concepts, Annals of the New York Academy of Sciences, vol.285, issue.1, pp.429-475, 2006.
DOI : 10.1359/jbmr.2003.18.1.150

B. Peters and L. Martini, Nutritional aspects of the prevention and treatment of osteoporosis, Arquivos Brasileiros de Endocrinologia & Metabologia, vol.54, issue.2, pp.179-185, 2010.
DOI : 10.1590/S0004-27302010000200014

J. Bonjour, Dietary Protein: An Essential Nutrient For Bone Health, Journal of the American College of Nutrition, vol.73, issue.sup6, pp.526-536, 2005.
DOI : 10.1080/07315724.2005.10719450

J. Kerstetter, O. Brien, K. Insogna, and K. , Dietary protein affects intestinal calcium absorption, Am J Clin Nutr, vol.68, pp.859-865, 1998.

P. Lips, R. Bouillon, N. Van-schoor, D. Vanderschueren, S. Verschueren et al., Reducing fracture risk with calcium and vitamin D, Clinical Endocrinology, vol.73, pp.277-285, 2010.
DOI : 10.1111/j.0300-0664.2009.03701.x

J. Thissen, J. Ketelslegers, and L. Underwood, Nutritional regulation of the insulin-like growth factors, Endocr Rev, vol.15, pp.80-101, 1994.

M. Schürch, R. Rizzoli, D. Slosman, L. Vadas, P. Vergnaud et al., Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture A randomized, double-blind, placebo-controlled trial Ann Intern Med, pp.801-809, 1998.

U. Barzel, The skeleton as an ion exchange system: Implications for the role of acid-base imbalance in the genesis of osteoporosis, Journal of Bone and Mineral Research, vol.50, issue.10, pp.1431-1437, 1995.
DOI : 10.1002/jbmr.5650101002

U. S. Barzel and L. K. Massey, Excess dietary protein can adversely affect bone, J Nutr, vol.128, pp.1051-1053, 1998.

R. Moskowitz, Role of collagen hydrolysate in bone and joint disease, Seminars in Arthritis and Rheumatism, vol.30, issue.2, pp.87-99, 2000.
DOI : 10.1053/sarh.2000.9622

Y. Koyama, A. Hirota, H. Mori, H. Takahara, K. Kuwaba et al., Ingestion of Gelatin Has Differential Effect on Bone Mineral Density and Body Weight in Protein Undernutrition., Journal of Nutritional Science and Vitaminology, vol.47, issue.1, pp.84-86, 2001.
DOI : 10.3177/jnsv.47.84

J. Wu, M. Fujioka, K. Sugimoto, G. Mu, and Y. Ishimi, Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats, Journal of Bone and Mineral Metabolism, vol.22, issue.6, pp.547-553, 2004.
DOI : 10.1007/s00774-004-0522-2

Y. Nomura, K. Oohashi, M. Watanabe, and S. Kasugai, Increase in bone mineral density through oral administration of shark gelatin to ovariectomized rats, Nutrition, vol.21, issue.11-12, pp.1120-1126, 2005.
DOI : 10.1016/j.nut.2005.03.007

F. Guillerminet, H. Beaupied, V. Fabien-soulé, D. Tomé, C. Benhamou et al., Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: An in vitro and in vivo study, Bone, vol.46, issue.3, pp.827-834, 2010.
DOI : 10.1016/j.bone.2009.10.035

H. Ohara, H. Matsumoto, K. Ito, K. Iwai, and K. Sato, Comparison of Quantity and Structures of Hydroxyproline-Containing Peptides in Human Blood after Oral Ingestion of Gelatin Hydrolysates from Different Sources, Journal of Agricultural and Food Chemistry, vol.55, issue.4, pp.1532-1535, 2007.
DOI : 10.1021/jf062834s

T. Nagy and A. Clair, Precision and Accuracy of Dual-Energy X-ray Absorptiometry for Determining in Vivo Body Composition of Mice, Obesity Research, vol.271, issue.5, pp.392-398, 2000.
DOI : 10.1038/oby.2000.47

C. Turner and D. Burr, Basic biomechanical measurements of bone: A tutorial, Bone, vol.14, issue.4, pp.595-608, 1993.
DOI : 10.1016/8756-3282(93)90081-K

D. Masso, R. Font, M. Capozza, R. Detarsio, G. Sosa et al., Long-bone biomechanics in mice selected for body conformation, Bone, vol.20, issue.6, pp.539-584, 1997.
DOI : 10.1016/S8756-3282(97)00055-0

A. Blais, A. Malet, T. Mikogami, C. Martin-rouas, and T. D. , Oral bovine lactoferrin improves bone status of ovariectomized mice, AJP: Endocrinology and Metabolism, vol.296, issue.6, pp.1281-1288, 2009.
DOI : 10.1152/ajpendo.90938.2008

A. Cano, S. Dapía, I. Noguera, B. Pineda, C. Hermenegildo et al., Comparative effects of 17??-estradiol, raloxifene and genistein on bone 3D microarchitecture and volumetric bone mineral density in the ovariectomized mice, Osteoporosis International, vol.348, issue.6, pp.793-800, 2008.
DOI : 10.1056/NEJMra022219

L. Sliwi?ski, J. Folwarczna, B. Nowi?ska, U. Cegie?a, M. Pytlik et al., A comparative study of the effects of genistein, estradiol and raloxifene on the murine skeletal system, Acta Biochimica Polonica, vol.2, pp.261-270, 2009.

C. Jochems, M. Lagerquist, C. Håkansson, C. Ohlsson, and H. Carlsten, Long-term anti-arthritic and anti-osteoporotic effects of raloxifene in established experimental postmenopausal polyarthritis, Clinical & Experimental Immunology, vol.67, issue.3, pp.593-597, 2008.
DOI : 10.1111/j.1365-2249.2008.03660.x

T. Schroeder, E. Jensen, and J. Westendorf, Runx2: A master organizer of gene transcription in developing and maturing osteoblasts, Birth Defects Research Part C: Embryo Today: Reviews, vol.277, issue.3, pp.213-238, 2005.
DOI : 10.1002/bdrc.20043

P. Marie, Transcription factors controlling osteoblastogenesis, Archives of Biochemistry and Biophysics, vol.473, issue.2, pp.98-105, 2008.
DOI : 10.1016/j.abb.2008.02.030

D. Burr, The contribution of the organic matrix to bone???s material properties, Bone, vol.31, issue.1, pp.8-11, 2002.
DOI : 10.1016/S8756-3282(02)00815-3

V. Mann, E. Hobson, B. Li, T. Stewart, S. Grant et al., A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality, Journal of Clinical Investigation, vol.107, issue.7, pp.899-907, 2001.
DOI : 10.1172/JCI10347

C. Li, M. Schaffler, H. Wolde-semait, C. Hernandez, and K. Jepsen, Genetic Background Influences Cortical Bone Response to Ovariectomy, Journal of Bone and Mineral Research, vol.20, issue.12, pp.2150-2158, 20056.
DOI : 10.1359/JBMR.050819

E. Aarden, Immunocytochemical demonstration of extracellular matrix proteins in isolated osteocytes, Histochemistry and Cell Biology, vol.52, issue.S1, pp.495-501, 1996.
DOI : 10.1007/BF02473312

B. Abelow, Cross-cultural association between dietary animal protein and hip fracture: A hypothesis, Calcified Tissue International, vol.24, issue.1, pp.14-22, 1992.
DOI : 10.1007/BF00297291

T. Adachi, Osteocyte calcium signaling response to bone matrix deformation, Journal of Biomechanics, vol.42, issue.15, pp.2507-2512, 2009.
DOI : 10.1016/j.jbiomech.2009.07.006

H. Ahlborg, Bone loss and bone size after menopause, N Engl J Med, vol.24349, issue.4, pp.327-361, 2003.
DOI : 10.1097/01.ogx.0000109262.37864.99
URL : http://lup.lub.lu.se/record/117047/file/623846.pdf

O. Albagha, Association of oestrogen receptor ?? gene polymorphisms with postmenopausal bone loss, bone mass, and quantitative ultrasound properties of bone, Journal of Medical Genetics, vol.42, issue.3, pp.240-246, 2005.
DOI : 10.1136/jmg.2004.023895

P. Ammann and R. Rizzoli, Bone strength and its determinants, Osteoporosis International, vol.18, issue.S3, pp.13-18, 2003.
DOI : 10.1016/S8756-3282(00)00268-4

P. Ammann, S. Bourrin, J. Bonjour, J. Meyer, and R. Rizzoli, Protein Undernutrition-Induced Bone Loss Is Associated with Decreased IGF-I Levels and Estrogen Deficiency, Journal of Bone and Mineral Research, vol.99, issue.Suppl 3, pp.683-690, 2000.
DOI : 10.1359/jbmr.2000.15.4.683

T. Arnett, Regulation of bone cell function by acid???base balance, Proceedings of the Nutrition Society, vol.36, issue.02, pp.511-531, 2003.
DOI : 10.1111/j.1469-7793.1998.495bh.x

M. Audran and E. Legrand, Ostéoporose: stratégie diagnostique et thérapie pratique; hors série, In Rhumatologie, 1993.

S. Bass, Exercise Before Puberty May Confer Residual Benefits in Bone Density in Adulthood: Studies in Active Prepubertal and Retired Female Gymnasts, Journal of Bone and Mineral Research, vol.10, issue.Suppl 1, pp.500-507, 1998.
DOI : 10.1359/jbmr.1998.13.3.500

B. We, International comparison of hip frature rates in 1988-1989, Osteoporos Int, vol.6, pp.69-75, 1996.

R. Baron, Molecular mechanisms of bone resorption: therapeutic implications, Rev Rhum Engl Ed, vol.63, issue.10, pp.633-641, 1996.

U. S. Barzel, The skeleton as an ion exchange system: Implications for the role of acid-base imbalance in the genesis of osteoporosis, Journal of Bone and Mineral Research, vol.50, issue.10, pp.1431-1437, 1995.
DOI : 10.1002/jbmr.5650101002

U. S. Barzel and L. K. Massey, Excess dietary protein can adversely affect bone, J Nutr, vol.128, issue.6, pp.1051-1054, 1998.

J. Bell and S. Whiting, Elderly women need dietary protein to maintain bone mass, Nutr Rev, vol.60, issue.10, 2002.

A. Berard, G. Bravo, and P. Gauthier, Meta-analysis of the effectiveness of physical activity for the prevention of bone loss in postmenopausal women, Osteoporosis International, vol.70, issue.4, pp.331-337, 1997.
DOI : 10.1007/BF01623773

P. V. Bodine and B. Komm, Vitamins and hormons. Tissue culture models for studies of hormon and vitamin action in bone cells, pp.101-151, 2002.

J. Bonadio, A murine skeletal adaptation that significantly increases cortical bone mechanical properties. Implications for human skeletal fragility., Journal of Clinical Investigation, vol.92, issue.4, pp.1697-705, 1993.
DOI : 10.1172/JCI116756

J. Bonjour, Calcium-enrichied foods and bone mass growth in prepubertal girls, J. Clin. Invest, issue.6, pp.99-1287, 1997.

J. P. Bonjour, Dietary Protein: An Essential Nutrient For Bone Health, Journal of the American College of Nutrition, vol.73, issue.sup6, pp.526-562, 2005.
DOI : 10.1080/07315724.2005.10719450

S. Bourrin, P. Ammann, J. Bonjour, and R. Rizzoli, Dietary proteinrestriction lowers plasma insulin-like growth factor I (IGF-I),impairs cortical bone formation, and induces osteoblastic resistanceto IGF-I in adult female rats, Endocrinology, vol.141, pp.3149-3155, 2000.

S. Bourrin, A. Toromanoff, P. Ammann, J. Bonjour, and R. Rizzoli, Dietary Protein Deficiency Induces Osteoporosis in Aged Male Rats, Journal of Bone and Mineral Research, vol.13, issue.Suppl 2, pp.1555-1563, 2000.
DOI : 10.1359/jbmr.2000.15.8.1555

M. Bouxeim and S. Radloff, Quantitative ultrasound of the calcaneus reflects the material properties of calcaneal trabecular bone, J Bone Min Res, vol.12, pp.839-846, 1997.

M. Bouxsein, E. Myers, and W. Hayes, Biomechanics of age-related fractures. Osteoporosis, pp.373-393, 1996.

M. L. Bouxsein, Ovariectomy-Induced Bone Loss Varies Among Inbred Strains of Mice, Journal of Bone and Mineral Research, vol.328, issue.7, pp.1085-92, 2005.
DOI : 10.1359/JBMR.050307

M. Bradney, Moderate Exercise During Growth in Prepubertal Boys: Changes in Bone Mass, Size, Volumetric Density, and Bone Strength: A Controlled Prospective Study, Journal of Bone and Mineral Research, vol.80, issue.12, pp.1814-1821, 1998.
DOI : 10.1359/jbmr.1998.13.12.1814

H. Burger, Risk Factors for Increased Bone Loss in an Elderly Population The Rotterdam Study, American Journal of Epidemiology, vol.147, issue.9, pp.871-879, 1998.
DOI : 10.1093/oxfordjournals.aje.a009541

D. B. Burr, The contribution of the organic matrix to bone???s material properties, Bone, vol.31, issue.1, pp.8-11, 2002.
DOI : 10.1016/S8756-3282(02)00815-3

J. Cadogan, Milk intake and bone mineral acquisition in adolescent girls: randomised, controlled intervention trial, BMJ, vol.315, issue.7118, pp.1255-1260, 1997.
DOI : 10.1136/bmj.315.7118.1255

J. Caetano_lopez, H. Canhao, and J. Fonseca, Osteoblasts and bone formation, Acat Reumatol port, vol.32, issue.2, pp.103-110, 2007.

A. Cano, Comparative effects of 17??-estradiol, raloxifene and genistein on bone 3D microarchitecture and volumetric bone mineral density in the ovariectomized mice, Osteoporosis International, vol.348, issue.6, pp.793-800, 2008.
DOI : 10.1056/NEJMra022219

J. Cardona and E. Pastor, Calcitonin versus etidronate for the treatment of postmenopausal osteoporosis: A meta-analysis of published clinical trials, Osteoporosis International, vol.49, issue.Suppl 2, pp.165-174, 1998.
DOI : 10.1007/BF01622285

J. Cauley, Estrogen replacement therapy and fractures in older women, Annals of medicine, vol.117, pp.1016-1037, 1995.

S. Censi, Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha, 2000.

Y. Chan, The effect of metabolic acidosis on vitamin D metabolites and bone histology in uremic rats. Calcif Tissue Int, pp.158-64, 1985.

G. Chan, Effects of dairy products on bone and body composition in pubertal girls, The Journal of Pediatrics, vol.126, issue.4, pp.551-556, 1995.
DOI : 10.1016/S0022-3476(95)70348-9

M. Chapuy, Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women, BMJ, vol.308, issue.6936, pp.1081-1082, 1994.
DOI : 10.1136/bmj.308.6936.1081

J. Chiu, Long-Term Vegetarian Diet and Bone Mineral Density in Postmenopausal Taiwanese Women, Calcified Tissue International, vol.60, issue.3, pp.245-254, 1997.
DOI : 10.1007/PL00005812

D. Clemmons, M. Seek, and L. Underwood, Supplemental essential amino acids augment the somatomedin-C/insulin-like growth factor I response to refeeding after fasting, Metabolism, vol.34, issue.4, p.34, 1985.
DOI : 10.1016/0026-0495(85)90230-6

D. Clemmons, 1985 Use of plasma somatomedin-C/insulin-like growth factor I measurements to monitor the response to nutritional repletion in malnourished patients, Am J Clin Nutr, vol.41, issue.2, pp.191-199

G. Cooper, Genetic Studies of Osteoporosis: What Have We Learned?, Journal of Bone and Mineral Research, vol.147, issue.10, pp.1646-121, 1999.
DOI : 10.1007/BF01626540

V. Coxam, Prevention of osteopaenia by phyto-oestrogens: animal studies, British Journal of Nutrition, vol.89, issue.5, pp.75-85, 2003.
DOI : 10.1079/BJN2002798

R. Cumming, Calcium intake and bone mass: A quantitative review of the evidence, Calcified Tissue International, vol.280, issue.suppl 1, pp.194-201, 1990.
DOI : 10.1007/BF02555919

J. Currey, The mechanical consequences of variation in the mineral content of bone, Journal of Biomechanics, vol.2, issue.1, pp.1-11, 1969.
DOI : 10.1016/0021-9290(69)90036-0

J. Currey, Effects of porosity and mineral content on th eYoung's modulus of bone. European society of biomechanics, p.104, 1986.

J. Currey, Bone Strength: What are We Trying to Measure?, Calcified Tissue International, vol.68, issue.4, pp.205-210, 2001.
DOI : 10.1007/s002230020040

A. Darling, Dietary protein and bone health: a systematic review and meta-analysis, American Journal of Clinical Nutrition, vol.90, issue.6, pp.1674-92, 2010.
DOI : 10.3945/ajcn.2009.27799

?. Dawson and B. Hughes, Effect of Calcium and Vitamin D Supplementation on Bone Density in Men and Women 65 Years of Age or Older, New England Journal of Medicine, vol.337, issue.10, pp.670-676, 1997.
DOI : 10.1056/NEJM199709043371003

?. Dawson and B. Hughes, Interaction of dietary calcium and protein in bone health in humans, J Nutr, vol.133, issue.3, pp.852-854, 2003.

B. Dawson-hughes, Calcium and protein in bone health, Proceedings of the Nutrition Society, vol.111, issue.02, pp.505-514, 2003.
DOI : 10.1007/s002230010062

B. Dawson-hughes, S. Harris, H. Rasmussen, L. Song, and G. Dallal, Effect of Dietary Protein Supplements on Calcium Excretion in Healthy Older Men and Women, The Journal of Clinical Endocrinology & Metabolism, vol.89, issue.3, pp.1169-73, 2004.
DOI : 10.1210/jc.2003-031466

P. Delmas, P. Hardy, P. Garnero, and M. Dain, Monitoring individual response to hormone replacement therapy with bone markers, Bone, vol.26, issue.6
DOI : 10.1016/S8756-3282(00)00271-4

E. Dennison, Determinants of bone loss in elderly men and women: a prospective study, 1999.

M. Ellerington, Intranasal salmon calcitonin for the prevention and treatment of postmenopausal osteoporosis, Calcified Tissue International, vol.i, issue.1, pp.6-11, 1996.
DOI : 10.1007/s002239900076

L. Ellfors, The variable incidence of hip fracture in Southern Europe: The MEDOS study, Osteoporosis International, vol.45, issue.Suppl, 1994.
DOI : 10.1007/BF01623349

K. Ensrud, Weight change and fractures in older women. Study od osteoporotic fractures Research group. Archives of international medicine, pp.857-863, 1997.

B. Ettinger, H. Genant, and C. Cann, Long-term estrogen replacement therapy prevents bone loss and fracture, Annals of internal medicine, vol.317, pp.1169-1174

B. Ettinger, Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators, JAMA, vol.282, issue.822, p.2124, 1999.

S. Ferrari, R. Rizzoli, and J. Bonjour, Genetic aspects of osteoporosis, Current Opinion in Rheumatology, vol.11, issue.4, pp.294-300, 1999.
DOI : 10.1097/00002281-199907000-00013

A. Flanagan and U. Sarma, In vitro models for osteoclast recruitment, pp.50-63, 1998.
DOI : 10.1007/978-0-585-38227-2_2

B. Frenkel, Regulation of adult bone turnover by sex steroids, Journal of Cellular Physiology, vol.99, issue.2, 2010.
DOI : 10.1002/jcp.22159

D. Feskanich, Protein Consumption and Bone Fractures in Women, American Journal of Epidemiology, vol.143, issue.5, pp.472-481, 1996.
DOI : 10.1093/oxfordjournals.aje.a008767

J. Freudenheim, Relationships between usual nutrient intake and bone-mineral content of women 35-65 years of age: longitudinal and cross-sectional analysis, Am J Clin Nutr, vol.44, issue.6, pp.863-76, 1986.

H. Freudiger and J. Bonjour, Bisphosphonates and extrarenal acid buffering capacity, Calcified Tissue International, vol.21, issue.1, pp.3-10, 1989.
DOI : 10.1007/BF02556234

D. Fontana, Ostéoporose, clinique, épidémiologie et approche thérapeutiques, médecine/science, pp.1297-305, 2001.

L. Frassetto, Worldwide Incidence of Hip Fracture in Elderly Women: Relation to Consumption of Animal and Vegetable Foods, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.55, issue.10, pp.585-92, 2000.
DOI : 10.1093/gerona/55.10.M585

Y. Fujikawa, The human osteoclast precursor circulates in the monocyte fraction, Endocrinology, vol.137, pp.4058-4060, 1996.

P. Gamero, E. Sornay-rendu, and P. Delmas, Low serum IGF-1 andoccurrence of osteoporotic fractures in postmenopausal women, Lancet, vol.355, pp.898-899, 2000.

Y. Gao, Estrogen prevents bone loss through transforming growth factor ?? signaling in T cells, Proceedings of the National Academy of Sciences, vol.101, issue.47, pp.16618-16641, 2004.
DOI : 10.1073/pnas.0404888101

Y. Gao, IFN-?? stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation, Journal of Clinical Investigation, vol.117, issue.1, pp.122-132, 2007.
DOI : 10.1172/JCI30074

P. Gardsell, Bone mass in an urban and a rural population: A comparative, population-based study in Southern Sweden, Journal of Bone and Mineral Research, vol.44, issue.1, pp.67-75, 1991.
DOI : 10.1002/jbmr.5650060112

R. Gehron, The cellular biology and molecular biochemistry of bone formation Disorders of Bone and Mineral Metabolism Measurement and significance of three-dimensional architecture to the mechanical integrity of trabecular bone, pp.241-264127, 1992.

R. Goulet, The relationship between the structural and orthogonal compressive properties of trabecular bone, Journal of Biomechanics, vol.27, issue.4, pp.375-389, 1994.
DOI : 10.1016/0021-9290(94)90014-0

D. Grady, Hormone therapy to prevent disease and prolong life in postmenopausal women, pp.1016-1037, 1992.

M. Hannan, Effect of Dietary Protein on Bone Loss in Elderly Men and Women: The Framingham Osteoporosis Study, Journal of Bone and Mineral Research, vol.35, issue.Suppl 3, pp.2504-2516, 2000.
DOI : 10.1359/jbmr.2000.15.12.2504

S. Harris, Four-year study of intermittent cyclic etidronate treatment of postmenopausal osteoporosis: Three years of blinded therapy followed by one year of open therapy, The American Journal of Medicine, vol.95, issue.6, pp.557-567, 1993.
DOI : 10.1016/0002-9343(93)90350-X

S. Harris, Effects of Risedronate Treatment on Vertebral and Nonvertebral Fractures in Women With Postmenopausal Osteoporosis<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>, JAMA, vol.282, issue.14, pp.1344-1352, 1999.
DOI : 10.1001/jama.282.14.1344

C. Hartmann, A Wnt canon orchestrating osteoblastogenesis, Trends in Cell Biology, vol.16, issue.3, pp.151-158, 2006.
DOI : 10.1016/j.tcb.2006.01.001

R. Heaney, Protein and calcium: antagonists or synergists?, Am J Clin Nut, vol.75, pp.609-619, 2002.

M. Horowitz, Cytokines and estrogen in bone: anti-osteoporotic effects, Science, vol.260, issue.5108, pp.626-627, 1993.
DOI : 10.1126/science.8480174

F. Hughes, J. Aubon, B. Arnett, and . Henderson, Culture of cells of the osteoblast lineage Bone mineral content in postmenopausal women: comparison of omnivores and vegetarians, Methods in Bone Biology Am J Clin Nutr, vol.50, issue.3, pp.1-49517, 1989.

T. Hutchinson, S. Polansky, and A. Feinstein, post menopausal oestrogens protect against fractures of hip and distal radius, lancet, vol.2, pp.705-709, 1979.

J. Ioannidis, Association of Polymorphisms of the Estrogen Receptor ?? Gene With Bone Mineral Density and Fracture Risk in Women: A Meta-Analysis, Journal of Bone and Mineral Research, vol.85, issue.11, pp.2048-2060, 2002.
DOI : 10.1359/jbmr.2002.17.11.2048

J. Jiang, A. Siller-jackson, and S. Burra, Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress, Frontiers in Bioscience, vol.12, issue.1, pp.1450-1462, 2007.
DOI : 10.2741/2159

R. Joakimsen, M. J. Fonnebo, and V. , Physical activity and predisposition for hip fractures: A review, Osteoporosis International, vol.122, issue.Suppl 103, pp.503-513, 1997.
DOI : 10.1007/BF02652555

O. Jonhnell, The apparent incidence of hip fracture in Europe : a study of national register sources. MEDOS study group, Osteoporosis Int, pp.298-302, 1992.

C. Johnston, Calcium Supplementation and Increases in Bone Mineral Density in Children, New England Journal of Medicine, vol.327, issue.2, pp.82-87, 1992.
DOI : 10.1056/NEJM199207093270204

C. Jonhston and C. Slemenda, Pathogenesis of postmenopausal osteoporotic fractures, Osteoporosis, pp.53-64, 1998.

H. Jones, Humeral hypertrophy in response to exercise, The Journal of Bone & Joint Surgery, vol.59, issue.2, p.59, 1977.
DOI : 10.2106/00004623-197759020-00012

T. Katagiri and N. Takahashi, Regulatory mechanisms of osteoblast and osteoclast differentiation, Oral Diseases, vol.281, issue.3, pp.147-59, 2002.
DOI : 10.1016/S0092-8674(00)80133-6

J. Kerstetter, Dietary protein and intestinal calcium absorption, Am J Clin Nutr, p.73, 2001.

J. Kerstetter, Dietary protein, calcium metabolism, and skeletal homeostasis revisited, Am J Clin Nutr, vol.78, issue.3, pp.584-592, 2003.

D. Kiel, Hip Fracture and the Use of Estrogens in Postmenopausal Women, New England Journal of Medicine, vol.317, issue.19, pp.1169-1174, 1987.
DOI : 10.1056/NEJM198711053171901

K. Iwai, Identification of Food-Derived Collagen Peptides in Human Blood after Oral Ingestion of Gelatin Hydrolysates, Journal of Agricultural and Food Chemistry, vol.53, issue.16, pp.6531-6536, 2005.
DOI : 10.1021/jf050206p

Y. Koyama, Ingestion of Gelatin Has Differential Effect on Bone Mineral Density and Body Weight in Protein Undernutrition., Journal of Nutritional Science and Vitaminology, vol.47, issue.1, pp.84-90, 2001.
DOI : 10.3177/jnsv.47.84

V. Krishnan, H. Bryant, and O. Macdougald, Regulation of bone mass by Wnt signaling, Journal of Clinical Investigation, vol.116, issue.5, pp.1202-1209, 2006.
DOI : 10.1172/JCI28551

S. Kudlacek, H. Schneider, O. Resch, R. Freudenthaler, and . Willvonseder, Gender differences in fracture risk and bone mineral density, Maturitas, vol.36, issue.3, pp.173-180, 2000.
DOI : 10.1016/S0378-5122(00)00149-3

P. Marie, Strontium ranelate: A physiological approach for optimizing bone formation and resorption, Bone, vol.38, issue.2, pp.10-14, 2006.
DOI : 10.1016/j.bone.2005.07.029

J. Lemann and . Jr, Relationship between Urinary Calcium and Net Acid Excretion as Determined by Dietary Protein and Potassium: A Review, Nephron, vol.81, issue.1, pp.18-25, 1999.
DOI : 10.1159/000046294

S. Leszek, A comparative study of the effects of genistein, estradiol and raloxifene on the murine skeletal system, Acta Biochimica Polonica, vol.2, issue.56, pp.261-270, 2009.

U. Liberman, Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis, N Eng J Med, vol.337, pp.382-387, 1995.

R. Lindsay, PREVENTION OF SPINAL OSTEOPOROSIS IN OOPHORECTOMISED WOMEN, The Lancet, vol.316, issue.8205, pp.705-709, 1980.
DOI : 10.1016/S0140-6736(80)92592-1

T. Lloyd, The effect of calcium supplementation and tanner stage on bone density, content and area in teenage women, Osteoporosis International, vol.32, issue.4, pp.276-283, 1996.
DOI : 10.1007/BF01623385

E. Lochmuller, Mechanical strength of the proximal femur as predicted from geometric and densitometric bone properties at the lower limb versus the distal radius, Bone, vol.30, issue.1, pp.207-223, 2002.
DOI : 10.1016/S8756-3282(01)00621-4

E. Lufkin, Treatment of Postmenopausal Osteoporosis with Transdermal Estrogen, Annals of Internal Medicine, vol.117, issue.1, pp.1-9, 1992.
DOI : 10.7326/0003-4819-117-1-1

J. Lutz, Calcium balance and acid-base status of women as affectedby increased protein intake and by sodium bicarbonateingestion, Am J Clin Nutr, vol.39, pp.281-288, 1984.

S. Maggi, Incidence of hip fractures in the elderly: A cross-national analysis, Osteoporosis International, vol.264, issue.4, pp.232-241, 1991.
DOI : 10.1007/BF03187467

L. Massey and S. Kynast-gales, Diets With Either Beef or Plant Proteins Reduce Risk of Calcium Oxalate Precipitation in Patients With a History of Calcium Kidney Stones, Journal of the American Dietetic Association, vol.101, issue.3, pp.326-331, 2001.
DOI : 10.1016/S0002-8223(01)00085-2

T. Mccarthy, Runx2 Integrates Estrogen Activity in Osteoblasts, Journal of Biological Chemistry, vol.278, issue.44, pp.43121-43130, 2003.
DOI : 10.1074/jbc.M306531200

V. Mann, A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality, Journal of Clinical Investigation, vol.107, issue.7, pp.899-907, 2001.
DOI : 10.1172/JCI10347

R. Marcus, Mechanisms of exercices effects on bone, Principles of bone biology, pp.1135-1146, 1996.

J. Mardon, Influence of High and Low Protein Intakes on Age-Related Bone Loss in Rats Submitted to Adequate or Restricted Energy Conditions, Calcified Tissue International, vol.125, issue.Suppl, pp.373-82, 2008.
DOI : 10.1007/s00223-008-9125-6

J. Mardon, Dietary Protein Supplementation Increases Peak Bone Mass Acquisition in Energy-Restricted Growing Rats, Pediatric Research, vol.71, issue.5, pp.513-521, 2009.
DOI : 10.1203/PDR.0b013e3181b9b4bb

P. Marie, Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation, Current Opinion in Rheumatology, vol.18, issue.Suppl 1, pp.11-16, 2006.
DOI : 10.1097/01.bor.0000229522.89546.7b

R. Mazess and H. Barden, Bone density in premenopausal women: effects of age, dietary intake, physical activity, smoking, and birth-control pills, Am J Clin Nutr, vol.53, issue.1, pp.132-174, 1991.

M. Morimichi and Y. Kuboki, Osteoblast-related gene expression of bone marrow cells during the osteoblastic differentiation induced by type I collagen, J.biochem, vol.129, pp.133-138, 2000.

J. Metz, Intakes of calcium, phosphorus, and protein, and physical-activity level are related to radial bone mass in young adult women, Am J Clin Nutr, vol.58, issue.4, pp.537-579, 1993.

P. Meunier and G. Boivin, Bone mineral density reflects low bone mass but also the degree of mineralisation of bone. Therapeutic applications, Bone, vol.5, pp.373-377, 1997.

H. Meyer, Dietary Factors and the Incidence of Hip Fracture in Middle-aged Norwegians: A Prospective Study, American Journal of Epidemiology, vol.145, issue.2, pp.117-140, 1997.
DOI : 10.1093/oxfordjournals.aje.a009082

V. Musey, S. Goldstein, P. Farmer, P. Moore, and L. Phillips, Differential Regulation of IGF-1 and IGF-Binding Protein-1 by Dietary Composition in Humans, The American Journal of the Medical Sciences, vol.305, issue.3, pp.131-139, 1993.
DOI : 10.1097/00000441-199303000-00001

L. Nachtigall, Estrogen replacement therapy I: a 10-year prospective study in the relationship to osteoporosis, Obstretics and gynecology, pp.277-281, 1979.

. Nakamura, Role of alpha(v)beta(3) integrin in osteoclast migration and formation of the sealing zone The influence of alcohol consumption on the risk of vertebral deformity. The European Vertebral Osteoporosis Study group, Journal of Cell Science Osteoporosis Int, vol.112, issue.7, pp.65-71, 1997.

S. Neale, Osteoclast differentiation from circulating mononuclear precursors in Paget???s disease is hypersensitive to 1,25-dihydroxyvitamin D3 and RANKL, Bone, vol.27, issue.3, pp.409-416, 2000.
DOI : 10.1016/S8756-3282(00)00345-8

P. Nijweide, The osteocyte, Principles of bone biology, 1996.

M. Nuttall and J. Gimble, Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?, Bone, vol.27, issue.2, pp.177-184, 2000.
DOI : 10.1016/S8756-3282(00)00317-3

S. Oesser, M. Adam, W. Babel, and J. Seifert, Oral administration of (14)C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL), J Nutr, vol.129, issue.10, pp.1891-1896, 1999.

R. Oreffo, Activation of the bone-derived latent TGF beta complex by isolated osteoclasts, Biochemical and Biophysical Research Communications, vol.158, issue.3, p.129, 1989.
DOI : 10.1016/0006-291X(89)92795-2

T. Owen, Pleitropic effects of vitamin D on osteoblast gene expression are related to the proliferative and differentiated state of bone cell phenotype: dependency upon basal levels of gene expression, duration of exposure, and bone matrix competency in normal rat osteoblast cultures, 1991.

A. Paganini-hill, Menopausal estrogen therapy and hip fractures. Annals of internal medecine, pp.28-31, 1981.

J. Pfeilschifter, Changes in Proinflammatory Cytokine Activity after Menopause, Endocrine Reviews, vol.23, issue.1, pp.90-119, 2002.
DOI : 10.1210/edrv.23.1.0456

J. Promislow, Protein Consumption and Bone Mineral Density in the Elderly : The Rancho Bernardo Study, American Journal of Epidemiology, vol.155, issue.7, pp.636-680, 2002.
DOI : 10.1093/aje/155.7.636

L. Quarles, Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: An in vitro model of osteoblast development, Journal of Bone and Mineral Research, vol.28, issue.6, pp.683-92, 1992.
DOI : 10.1002/jbmr.5650070613

P. Rapuri, Protein intake: effects on bone mineral density and the rate of bone loss in elderly women, Am J Clin Nutr, vol.77, issue.6, pp.1517-1542, 2003.

I. Reid, Effect of Calcium Supplementation on Bone Loss in Postmenopausal Women, New England Journal of Medicine, vol.328, issue.7, pp.460-464, 1993.
DOI : 10.1056/NEJM199302183280702

C. Riggs, G. Whitehouse, and A. Boyde, Pathology of the distal condyles of the third metacarpal and third metatarsal bones of the horse, Equine Veterinary Journal, vol.40, issue.1, pp.140-148, 1999.
DOI : 10.1111/j.2042-3306.1999.tb03807.x

R. Rizzoli and J. Bonjour, Determinants of Peak Bone Mass and Mechanisms of Bone Loss, Osteoporosis International, vol.9, issue.S2, pp.17-23, 1999.
DOI : 10.1007/PL00004155

. Rochira, Bone loss, sex steroids and male age related hypogonadism, J Endocrinol Invest, vol.28, pp.46-54, 2005.

Z. Roughead, Is the interaction between dietary protein and calcium destructive or constructive for bone?, J Nutr, vol.133, issue.3, pp.866-869, 2003.

J. Rubin, H. Rubon, and C. Et-rubon, Constraints of experimental paradigms used to model the aging squeleton, the Aging skeleton, pp.27-36, 1999.

P. Sambrook, Genetic determinants of bone mass, Osteoporosis, pp.477-482, 1996.

M. Schurch, Proteins supplement increase serum insulin like growth factor I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial, Ann Intern Med, issue.10, pp.128801-128810, 1998.

E. Seeman, The effect of tobacco and alcohol use on bone. Osteoporosis, pp.577-597, 1996.

E. Seeman, Fracture Site-Specific Deficits in Bone Size and Volumetric Density in Men with Spine or Hip Fractures, Journal of Bone and Mineral Research, vol.13, issue.1, pp.120-127, 2001.
DOI : 10.1359/jbmr.2001.16.1.120

D. Sellmeyer, A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group, Am J Clin Nutr, vol.73, issue.1, pp.118-140, 2001.

D. Skaggs, Increased Body Weight and Decreased Radial Cross-Sectional Dimensions in Girls with Forearm Fractures, Journal of Bone and Mineral Research, vol.166, issue.7, pp.1337-1379, 2001.
DOI : 10.1359/jbmr.2001.16.7.1337

E. Smith, Recent experimental and clinical findings in the skeleton associated with loss of estrogen hormone or estrogen receptor activity, The Journal of Steroid Biochemistry and Molecular Biology, vol.118, issue.4-5, 2010.
DOI : 10.1016/j.jsbmb.2009.10.016

B. Snyder and W. Hayes, Multiaxial structure-propertyrelations in trabecular bone, mow VC, p.131, 1990.

T. Sugimoto, K. Nishiyama, F. Kuribayashi, and K. Chihara, Serum Levels of Insulin-like Growth Factor (IGF) I, IGF-Binding Protein (IGFBP)-2, and IGFBP-3 in Osteoporotic Patients with and without Spinal Fractures, Journal of Bone and Mineral Research, vol.9, issue.8, pp.1272-1279, 1997.
DOI : 10.1359/jbmr.1997.12.8.1272

Y. Takeuchi, M. Suzawa, T. Kikuchi, E. Nishida, T. Fujita et al., Differentiation and Transforming Growth Factor-?? Receptor Down-regulation by Collagen-??2??1 Integrin Interaction Is Mediated by Focal Adhesion Kinase and Its Downstream Signals in Murine Osteoblastic Cells, Journal of Biological Chemistry, vol.272, issue.46, pp.29309-29316, 1997.
DOI : 10.1074/jbc.272.46.29309

S. Teitelbaum, The osteoclast and osteoporosis, Mt Sinai J Med, vol.63, issue.56, pp.399-402, 1996.

S. Teitelbaum, Osteoclasts, integrins, and osteoporosis, Journal of Bone and Mineral Metabolism, vol.18, issue.6, pp.344-353, 2000.
DOI : 10.1007/s007740070007

J. Thissen, J. Pucilowska, and L. Underwood, 1994 Differential regulation of insulin-like growth factor I (IGF-I) and IGF binding protein-1 messenger ribonucleic acids by amino acid availability and growth hormone in rat hepatocyte primary culture, Endocrinology, vol.134, issue.3, pp.1570-1576

J. Thissen, J. Ketelslegers, and L. Underwood, Nutritional regulation of the insulin-like growth factors, Endocr Rev. Feb, vol.15, issue.1, pp.80-101, 1994.

J. Thissen and L. Underwood, Translational status of the insulin-like growth factor-I mRNAs in liver of protein-restricted rats, Journal of Endocrinology, vol.132, issue.1, pp.141-148
DOI : 10.1677/joe.0.1320141

C. Turner, Bone Strength: Current Concepts, Annals of the New York Academy of Sciences, vol.285, issue.1, pp.429-446, 2006.
DOI : 10.1359/jbmr.2003.18.1.150

D. Ulrich, The ability of three-dimensional structural indices to reflect mechanical aspects of trabecular bone, Bone, vol.25, issue.1, pp.55-60, 1999.
DOI : 10.1016/S8756-3282(99)00098-8

. Vanderschueren, Androgens and bone, Current Opinion in Endocrinology, Diabetes and Obesity, vol.15, issue.3, pp.250-254, 2008.
DOI : 10.1097/MED.0b013e3282fe6ca9

M. Wang, Bone Mass and Hip Axis Length in Healthy Asian, Black, Hispanic, and White American Youths, Journal of Bone and Mineral Research, vol.6, issue.Suppl, pp.1922-1957, 1997.
DOI : 10.1359/jbmr.1997.12.11.1922

M. Wang, L. Villa, M. Marcus, R. Kelsey, and J. , Associations of vitamin C, calcium and protein with bone mass in postmenopausal Mexican American women, Osteoporosis International, vol.95, issue.6, pp.533-541, 1997.
DOI : 10.1007/BF02652558

M. Watanabe-kamiyama, Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rats, Journal of Agricultural and Food Chemistry, vol.58, issue.2, pp.835-841, 2010.
DOI : 10.1021/jf9031487

N. Weiss, Decreased Risk of Fractures of the Hip and Lower Forearm with Postmenopausal Use of Estrogen, New England Journal of Medicine, vol.303, issue.21, pp.1195-1198, 1980.
DOI : 10.1056/NEJM198011203032102

M. Weitzmann and R. Pacifici, The role of T lymphocytes in bone metabolism, Immunological Reviews, vol.37, issue.1, pp.154-168, 2005.
DOI : 10.1016/S0092-8674(00)81109-5

G. Xiao, Role of the alpha 2-Integrin in Osteoblast-specific Gene Expression and Activation of the Osf2 Transcription Factor, Journal of Biological Chemistry, vol.273, issue.49, pp.32988-94, 1998.
DOI : 10.1074/jbc.273.49.32988

S. Yamagushi, Study of a rat model for calcium oxalate crystal formation without severe renal damage in selected conditions, International Journal of Urology, vol.142, issue.3, pp.290-298, 2005.
DOI : 10.1007/BF00307936

H. Zhao, How Do Bone Cells Secrete Proteins?, Adv Exp Med Biol, vol.658, pp.105-114, 2010.
DOI : 10.1007/978-1-4419-1050-9_11