Prefrontal interactions reflect future task operations, Nature Neuroscience, vol.10, issue.1, pp.75-81, 2003. ,
DOI : 10.1038/nn987
The Architecture of Cognitive Control in the Human Prefrontal Cortex, Science, vol.302, issue.5648, pp.1181-1185, 2003. ,
DOI : 10.1126/science.1088545
An information theoretical approach to prefrontal executive function, Trends in Cognitive Sciences, vol.11, issue.6, pp.229-235, 2007. ,
DOI : 10.1016/j.tics.2007.04.005
Cognitive control, hierarchy and the rostrocaudal organization of the frontal lobes, Trends Cogn. Sci, 2008. ,
Neural Mechanisms of Transient and Sustained Cognitive Control during Task Switching, Neuron, vol.39, issue.4, pp.713-726, 2003. ,
DOI : 10.1016/S0896-6273(03)00466-5
The Role of the Medial Frontal Cortex in Cognitive Control, Science, vol.306, issue.5695, pp.443-447, 2004. ,
DOI : 10.1126/science.1100301
Action sets and decisions in the medial frontal cortex, Trends in Cognitive Sciences, vol.8, issue.9, pp.410-417, 2004. ,
DOI : 10.1016/j.tics.2004.07.009
Functional organization of the medial frontal cortex, Current Opinion in Neurobiology, vol.17, issue.2, pp.220-227, 2007. ,
DOI : 10.1016/j.conb.2007.03.001
Prefrontal-cingulate interactions in action monitoring, Nature Neuroscience, vol.3, issue.5, pp.516-520, 2000. ,
DOI : 10.1038/74899
The neural system that bridges reward and cognition in humans: An fMRI study, Proc. Natl. Acad. Sci. USA 99, pp.5669-5674, 2002. ,
DOI : 10.1073/pnas.082111099
URL : https://hal.archives-ouvertes.fr/hal-00349710
Anterior Cingulate Conflict Monitoring and Adjustments in Control, Science, vol.303, issue.5660, pp.1023-1026, 2004. ,
DOI : 10.1126/science.1089910
Changes in connectivity profiles define functionally distinct regions in human medial frontal cortex, Proc. Natl. Acad. Sci. USA 101, pp.13335-13340, 2004. ,
DOI : 10.1073/pnas.0403743101
Triangulating a Cognitive Control Network Using Diffusion-Weighted Magnetic Resonance Imaging (MRI) and Functional MRI, Journal of Neuroscience, vol.27, issue.14, pp.3743-3752, 2007. ,
DOI : 10.1523/JNEUROSCI.0519-07.2007
Connectivity-Based Parcellation of Human Cingulate Cortex and Its Relation to Functional Specialization, Journal of Neuroscience, vol.29, issue.4, pp.1175-1190, 2009. ,
DOI : 10.1523/JNEUROSCI.3328-08.2009
Principles of Behavior (Appleton-Century-Crofts, 1943. ,
Activation and Behavior, 1962. ,
Organization of Action Sequences and the Role of the Pre-SMA, Journal of Neurophysiology, vol.91, issue.2, pp.978-993, 2004. ,
DOI : 10.1152/jn.00651.2003
Attention to Intention, Science, vol.303, issue.5661, pp.1208-1210, 2004. ,
DOI : 10.1126/science.1090973
Human Medial Frontal Cortex Mediates Unconscious Inhibition of Voluntary Action, Neuron, vol.54, issue.5, pp.697-711, 2007. ,
DOI : 10.1016/j.neuron.2007.05.016
Switching from automatic to controlled action by monkey medial frontal cortex, Nature Neuroscience, vol.76, issue.2, pp.240-248, 2007. ,
DOI : 10.1038/nn1830
Distributed Neural Representation of Expected Value, Journal of Neuroscience, vol.25, issue.19, pp.4806-4812, 2005. ,
DOI : 10.1523/JNEUROSCI.0642-05.2005
Supplementary Motor Area Encodes Reward Expectancy in Eye-Movement Tasks, Journal of Neurophysiology, vol.94, issue.2, pp.1325-1335, 2005. ,
DOI : 10.1152/jn.00022.2005
Learned Predictions of Error Likelihood in the Anterior Cingulate Cortex, Science, vol.307, issue.5712, pp.1118-1121, 2005. ,
DOI : 10.1126/science.1105783
Neuronal Correlates of Goal-Based Motor Selection in the Prefrontal Cortex, Science, vol.301, issue.5630, pp.229-232, 2003. ,
DOI : 10.1126/science.1084204
Anticipation of conflict monitoring in the anterior cingulate cortex and the prefrontal cortex, Proc. Natl. Acad. Sci. USA, pp.10330-10334, 2007. ,
DOI : 10.1073/pnas.0703225104
Avoiding another mistake: Error and posterror neural activity associated with adaptive posterror behavior change, Cognitive, Affective, & Behavioral Neuroscience, vol.7, issue.4, pp.317-326, 2007. ,
DOI : 10.3758/CABN.7.4.317
Optimal decision making and the anterior cingulate cortex, Nature Neuroscience, vol.336, issue.7, pp.940-947, 2006. ,
DOI : 10.1038/nn1724
Choice, uncertainty and value in prefrontal and cingulate cortex, Nature Neuroscience, vol.9, issue.4, pp.389-397, 2008. ,
DOI : 10.1038/nn2066
fMRI and its interpretations: an illustration on directional selectivity in area V5/MT, Trends in Neurosciences, vol.31, issue.9, pp.444-453, 2008. ,
DOI : 10.1016/j.tins.2008.06.004
On the role of general system theory for functional neuroimaging, Journal of Anatomy, vol.25, issue.6, pp.443-470, 2004. ,
DOI : 10.1016/S0924-977X(02)00108-6
Lateralized Cognitive Processes and Lateralized Task Control in the Human Brain, Science, vol.301, issue.5631, pp.384-386, 2003. ,
DOI : 10.1126/science.1086025
Cognition and medial frontal cortex in health and disease, Current Opinion in Neurology, vol.19, issue.6, pp.586-592, 2006. ,
DOI : 10.1097/01.wco.0000247609.36482.ae
Neuroimaging of Performance Monitoring: Error Detection and Beyond, Cortex, vol.40, issue.4-5, pp.593-604, 2004. ,
DOI : 10.1016/S0010-9452(08)70155-2
Dissociation between conflict detection and error monitoring in the human anterior cingulate cortex, Proc. Natl. Acad. Sci. USA 99, pp.16354-16359, 2002. ,
DOI : 10.1073/pnas.252521499
Conflict monitoring and cognitive control., Psychological Review, vol.108, issue.3, pp.624-652, 2001. ,
DOI : 10.1037/0033-295X.108.3.624
Anterior cingulate cortex and conflict detection: An update of theory and data, Cognitive, Affective, & Behavioral Neuroscience, vol.7, issue.4, pp.367-379, 2007. ,
DOI : 10.3758/CABN.7.4.367
Two Mechanisms for Task Switching in the Prefrontal Cortex, Journal of Neuroscience, vol.29, issue.16, pp.5135-5142, 2009. ,
DOI : 10.1523/JNEUROSCI.2828-08.2009
Conflict monitoring and decision making: Reconciling two perspectives on anterior cingulate function, Cognitive, Affective, & Behavioral Neuroscience, vol.7, issue.4, pp.356-366, 2007. ,
DOI : 10.3758/CABN.7.4.356
Introduction to the Theory of, Neural Computation, 1991. ,
Free-energy and the brain, Synthese, vol.335, issue.1, pp.417-458, 2007. ,
DOI : 10.1007/s11229-007-9237-y
Both supplementary and presupplementary motor areas are crucial for the temporal organization of multiple movements, J. Neurophysiol, vol.80, pp.3247-3260, 1998. ,
The Effect of Cingulate Cortex Lesions on Task Switching and Working Memory, Journal of Cognitive Neuroscience, vol.87, issue.3, pp.338-353, 2003. ,
DOI : 10.1016/S0168-0102(00)00198-X
Role for Cingulate Motor Area Cells in Voluntary Movement Selection Based on Reward, Science, vol.282, issue.5392, pp.1335-1338, 1998. ,
DOI : 10.1126/science.282.5392.1335
Motivation: Theories ad Principles, 2004. ,
The Architecture of Cognitive Control in the Human Prefrontal Cortex, Science, vol.302, issue.5648, pp.1181-1185, 2003. ,
DOI : 10.1126/science.1088545
Influenza: old and new threats, Nature Medicine, vol.18, issue.12s, p.82, 2004. ,
DOI : 10.1016/S1286-4579(00)01351-4
Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin, Annual Review of Biochemistry, vol.69, issue.1, p.531, 2000. ,
DOI : 10.1146/annurev.biochem.69.1.531
Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic, Nature, vol.22, issue.7250, p.1122, 2009. ,
DOI : 10.1038/nature08182
is the current seasonal vaccine strain In the swine lineage, classical swine HAs (A/swine/Iowa/15/1930 and A/swine/Ohio/511445/2007) are listed along with swine-origin human viruses (A, 1976. ,
Dating the emergence of pandemic influenza viruses, Proceedings of the National Academy of Sciences, vol.106, issue.28, p.11709, 2009. ,
DOI : 10.1073/pnas.0904991106
Historical Perspective ??? Emergence of Influenza A (H1N1) Viruses, New England Journal of Medicine, vol.361, issue.3, p.279, 2009. ,
DOI : 10.1056/NEJMra0904322
Swine Influenza A Outbreak, Fort Dix, New Jersey, 1976, Emerging Infectious Diseases, vol.12, issue.1, p.23, 2006. ,
DOI : 10.3201/eid1201.050965
The Structure and Receptor Binding Properties of the 1918 Influenza Hemagglutinin, Science, vol.303, issue.5665, p.1838, 2004. ,
DOI : 10.1126/science.1093155
Structure of the Uncleaved Human H1 Hemagglutinin from the Extinct 1918 Influenza Virus, Science, vol.303, issue.5665, p.1866, 2004. ,
DOI : 10.1126/science.1093373
The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype), Cell, vol.31, issue.2, p.417, 1982. ,
DOI : 10.1016/0092-8674(82)90135-0
Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus, New England Journal of Medicine, vol.361, issue.20, p.1945, 2009. ,
DOI : 10.1056/NEJMoa0906453
1918 Influenza: the Mother of All Pandemics, Emerging Infectious Diseases, vol.12, issue.1, p.15, 2006. ,
DOI : 10.3201/eid1209.05-0979
Hospitalized Patients with 2009 H1N1 Influenza in the United States, April???June 2009, Pandemic Influenza A (H1N1) Virus Hospitalizations Investigation Team], p.1935, 2009. ,
DOI : 10.1056/NEJMoa0906695
Clinical Features of the Initial Cases of 2009 Pandemic Influenza A (H1N1) Virus Infection in China, H1N1) 2009 Clinical Investigation Group of China, p.2507, 2009. ,
DOI : 10.1056/NEJMoa0906612
Effects of Glycosylation on the Properties and Functions of Influenza Virus Hemagglutinin, The Journal of Infectious Diseases, vol.176, issue.s1, p.24, 1997. ,
DOI : 10.1086/514170
Naturally Occurring Human Monoclonal Antibodies Neutralize both 1918 and 2009 Pandemic Influenza A (H1N1) Viruses, Journal of Virology, vol.84, issue.6, p.3127, 2010. ,
DOI : 10.1128/JVI.02184-09
Preexisting Immunity to Pandemic (H1N1) 2009, Emerging Infectious Diseases, vol.15, issue.11, p.1847, 2009. ,
DOI : 10.3201/eid1511.090685
URL : http://doi.org/10.3201/eid1511.090685
Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population, Proceedings of the National Academy of Sciences, vol.106, issue.48, p.20365, 2009. ,
DOI : 10.1073/pnas.0911580106
The work was supported in part by NIH grants AI058113 (I, ), predoctoral fellowships from the Achievement Rewards for College Scientists Foundation and the NIH Molecular Evolution Training Program GM080209 (D.C.E.), and the Skaggs Institute for Chemical Biology. X-ray diffraction data sets were collected at the Stanford Synchrotron Radiation Lightsource beamline 9-2 and at the Advanced Photon Source beamline 23ID-B (GM/CA-CAT) ,
Use of the Advanced Photon Source (APS) was supported by the U.S. Department of Energy, Basic Energy Sciences, Office of Science, under contract no. DE-AC02-06CH11357. We thank P. Palese (Mount Sinai School of Medicine) for providing the CA04 clone and helpful commentsVanderbilt University) for expert technical assistance, H. Tien and D. Marciano of the Robotics Core at the Joint Center for Structural Genomics for automated crystal screening, and M. Becker and the staff of the APS GM/CA CAT 23-ID-B for beamline support, whole or in part with federal funds from National Cancer Institute This is publication 20395 from the Scripps Research Institute. Coordinates and structure factors are deposited in the PDB [3LZG for CA04 HA (two trimers) and 3LZF for 1918 HA/2D1 complex]. Vanderbilt University has applied for a provisional patent covering the diagnostic and therapeutic use of antibodies described in this paper. J.E.C. Jr. is a founder of the vaccine company Corbeau Biotech LLC and has consulted for MedImmune ,
Strategy application disorder: the role of the frontal lobes in human multitasking, Psychological Research, vol.63, issue.3-4, p.279, 2000. ,
DOI : 10.1007/s004269900006
How Green Is the Grass on the Other Side? Frontopolar Cortex and the Evidence in Favor of Alternative Courses of Action, Neuron, vol.62, issue.5, p.733, 2009. ,
DOI : 10.1016/j.neuron.2009.05.014
Role for Cingulate Motor Area Cells in Voluntary Movement Selection Based on Reward, Science, vol.282, issue.5392, p.1335, 1998. ,
DOI : 10.1126/science.282.5392.1335
Optimal decision making and the anterior cingulate cortex, Nature Neuroscience, vol.336, issue.7, p.940, 2006. ,
DOI : 10.1038/nn1724
Motivation and cognitive control in the human prefrontal cortex, Nature Neuroscience, vol.19, issue.7, p.939, 2009. ,
DOI : 10.1016/j.neuroimage.2004.07.041
Fictive Reward Signals in the Anterior Cingulate Cortex, Science, vol.324, issue.5929, p.948, 2009. ,
DOI : 10.1126/science.1168488
Distributed Neural Representation of Expected Value, Journal of Neuroscience, vol.25, issue.19, p.4806, 2005. ,
DOI : 10.1523/JNEUROSCI.0642-05.2005
FMRI Visualization of Brain Activity during a Monetary Incentive Delay Task, NeuroImage, vol.12, issue.1, p.20, 2000. ,
DOI : 10.1006/nimg.2000.0593
Instructed Delay Activity in the Human Prefrontal Cortex is Modulated by Monetary Reward Expectation, Cerebral Cortex, vol.13, issue.3, p.318, 2003. ,
DOI : 10.1093/cercor/13.3.318
Efferent Association Pathways from the Rostral Prefrontal Cortex in the Macaque Monkey, Journal of Neuroscience, vol.27, issue.43, p.11573, 2007. ,
DOI : 10.1523/JNEUROSCI.2419-07.2007
Medial prefrontal cell activity signaling prediction errors of action values, Nature Neuroscience, vol.93, issue.5, p.647, 2007. ,
DOI : 10.1126/science.1069504
IMAGING VALUATION MODELS IN HUMAN CHOICE, Annual Review of Neuroscience, vol.29, issue.1, p.417, 2006. ,
DOI : 10.1146/annurev.neuro.29.051605.112903
Circular analysis in systems neuroscience: the dangers of double dipping, Nature Neuroscience, vol.12, issue.5, p.535, 2009. ,
DOI : 10.1016/j.neuroimage.2004.07.022
Expe: An expandable programming language for on-line psychological experiments, Behavior Research Methods, Instruments, & Computers, vol.20, issue.3, p.322, 1997. ,
DOI : 10.3758/BF03200583
Dissociating the role of the medial and lateral anterior prefrontal cortex in human planning, Proceedings of the National Academy of Sciences, vol.97, issue.13, p.7651, 2000. ,
DOI : 10.1073/pnas.130177397