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Synthèse, caractérisation et criblage biologique de nouveaux dérivés ferrocéniques des flavonoïdes : chalcones, aurones, flavones et flavonols

Abstract : Flavonoids are antioxidants from the plants, and their protecting effects on the organism are now well known, since they are called " nutraceuticals ". Ferrocene is a stable and lipophilic organometallic complex, possessing a stable FeII/FeIII stable redox couple. Ferrocene-containing bioactive molecules possess new biological activities. For example, ferrocene can increase the existing activity as well as the therapeutical spectrum of a drug, but can also induce additional biological properties. The aim of this work is to join these two redox active entities in order to create new series of bioactive molecules. We will explore the design, synthesis, and chemical as well as biological properties of several ferrocene-substituted flavonoid subfamilies. We will see that the synthesis of these derivatives required original synthesis protocols, and the obtained molecules are promising against a variety of biological targets, such as HIV virus, cancer of even some staphylococcus bacterias.
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https://pastel.archives-ouvertes.fr/pastel-00661343
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Submitted on : Thursday, January 19, 2012 - 11:36:44 AM
Last modification on : Tuesday, September 22, 2020 - 3:58:42 AM
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  • HAL Id : pastel-00661343, version 1

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Jean-Philippe Monserrat. Synthèse, caractérisation et criblage biologique de nouveaux dérivés ferrocéniques des flavonoïdes : chalcones, aurones, flavones et flavonols. Biochimie, Biologie Moléculaire. Université Pierre et Marie Curie - Paris VI, 2011. Français. ⟨pastel-00661343⟩

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