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Des isonitriles aux hydrazones : Réactions multicomposants et Synthèses d'hétérocycles

Abstract : Multicomponent reactions (MCR), as one-pot reactions, are effictient to synthesis target compounds with at least 3-starting materials. This methodology is very useful, in particular for heterocycle synthesis. Isocyanides, due to their specific reactivity, are favorite starting materials for these reactions. In first hand, a new oxazole-synthesis was discovered. Two reactions are in competition, that is why this study further stress the influence of the base on the chemoselectivity of the process. In second hand, research have been made on hydrazones. A new 3-components synthesis was discovered. This reaction coupled with a Fischer synthesis is an efficient way to obtain indole compounds. Moreover, these hydrazones allow us to discover a new reaction of cyclisation/oxidation to form pyrazolidinones. This new reaction applied to product prepared thanks to the Ugi coupling, become a new post-condensation reaction for these compounds.
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Submitted on : Tuesday, February 7, 2012 - 8:03:18 PM
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Caroline Ronsseray. Des isonitriles aux hydrazones : Réactions multicomposants et Synthèses d'hétérocycles. Chimie organique. Ecole Polytechnique X, 2011. Français. ⟨pastel-00664985⟩

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