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From isocyanide based multicomponent reactions to heterocyclic synthesis

Abstract : This work highlights the potential of multicomponent couplings isocyanides in heterocyclic chemistry. Two axes were particularly investigated through the Ugi-Smiles coupling and the Nef reaction. We have demonstrated the reactivity of 4-hydrpxypyridines and pyrimidines in Ugi-Smiles coupling, these reactions have been applied to the synthesis of antimalarial analogues. Several applications of Ugi and Ugi-Smiles adducts have been explored using radical chemistry (xanthates as well as oxidative couplings). We have also explored the chemistry of dihalogenoisocyanides in various heterocyclic synthesis.
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Submitted on : Tuesday, October 9, 2012 - 11:24:08 AM
Last modification on : Wednesday, May 11, 2022 - 3:22:02 PM
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  • HAL Id : pastel-00739959, version 1


Pravin Patil. From isocyanide based multicomponent reactions to heterocyclic synthesis. Organic chemistry. Ecole Polytechnique X, 2012. English. ⟨pastel-00739959⟩



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