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Nanocristaux à luminescence persistante : nouveaux concepts pour l'imagerie in vivo

Abstract : Persistent luminescence nanocrystals were recently introduced in the field of small animal optical imaging as original alternative to common photoluminescent systems intended for photonic detection in vivo. Acting as optical capacitors, these materials possess the ability to be excited before the injection to living animals and subsequently emit a NIR luminescence signal located within the tissue transparency window, without further illumination of the probe, for dozens of minutes. This technique provides an efficient solution to the autofluorescence problem from living tissues and allows a significant increase in signal to noise ratio during the detection. However, previous work not only revealed that this first generation of nanoparticles could hardly be followed more than one hour after the injection to small animals, but that it was also very likely to undergo rapid liver capture by the mononuclear phagocyte system. In order to overcome these essential limitations, we introduce a novel generation of persistent luminescence nanoparticles whose optical properties allow in situ activation of the probe through living tissues. The material can though be activated after its injection to the animal, allowing to retrieve persistent luminescence signal at any time. A proper optimization of surface characteristics also led to a significant increase of these nanoparticles circulation time, responsible for the first proof of passive targeting in vivo, achieved by taking advantage of the enhanced permeability and retention effect within the tumor microenvironment.
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Contributor : Thomas Maldiney Connect in order to contact the contributor
Submitted on : Thursday, June 6, 2013 - 4:16:09 PM
Last modification on : Wednesday, December 15, 2021 - 10:03:26 AM
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  • HAL Id : pastel-00831281, version 1


Thomas Maldiney. Nanocristaux à luminescence persistante : nouveaux concepts pour l'imagerie in vivo. Matériaux. Université Pierre et Marie Curie - Paris VI, 2012. Français. ⟨pastel-00831281⟩



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