Application de la Chimie Radicalaire des Xanthates à la Synthèse de Composés Biologiquement Actifs Possédant un Noyau Aromatique

Abstract : This thesis mainly deals with various aspects of xanthate radical chemistry. The first chapter is a general introduction to radical chemistry and provides an overview of the xanthate radical chemistry. The next chapter presents a new methodology for the synthesis of polycyclic aromatic compounds from strained epoxy-olefins. The third chapter describes the total synthesis of the purported structure of flossonol and of one of its isomers and concludes with the resolution of the structure of the natural product. The next section presents the study of different strategies for the synthesis of pseudoptéroxazole. In this work, a method of net contra-thermodynamic isomerization of carbon- carbon trisubstituted endocyclic double bonds has been developed and is the subject of the fifth chapter. The sixth part of the manuscript deals with an attempt to synthesize the structure of eudesmanes and finally , the seventh chapter presents a methodology for the synthesis of benzene derivatives through a 1-5 acyl transfer starting from a 3-methylene-1,4-cyclohexadiene.
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Submitted on : Wednesday, January 29, 2014 - 2:05:28 PM
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Raphaël Guignard. Application de la Chimie Radicalaire des Xanthates à la Synthèse de Composés Biologiquement Actifs Possédant un Noyau Aromatique. Chimie organique. Ecole Polytechnique X, 2013. Français. ⟨pastel-00938415⟩

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