Effets d'un extrait de quinoa enrichi en 20-hydroxyecdysone dans un modèle d'obésité nutritionnelle : application clinique

Abstract : Obesity is a complex disease which is dramatically increasing worldwide. Following the example of many drugs that were developed from plants molecules, new natural active principles are currently being evaluated in order to prevent or to treat metabolic disorders. Among them, phytoecdysteroids, and mainly 20-hydroxyecdysone present in quinoa, have displayed beneficial pharmacological effects. Thus, they would be potentially active candidates against obesity. The objective of this thesis is to highlight the properties of a quinoa extract enriched in 20-hydroxyecdysone on overweight and obesity and to characterize their effects.First, the ingestion of 20-hydroxyecdysone enriched quinoa extract by mice fed a high-fat diet limited adipose tissue development, without modifying food intake. In adipose tissue, these effects were associated with a reduction of the amount of transcripts of genes involved in lipid storage and inflammation. Energy balance analyses showed that quinoa extract increased energy expenditure via an increase in glucose oxidation and diminished lipid intestinal absorption. Then, in overweight and obese subjects, quinoa extract displayed a tendency to prevent weight and fat mass regain after energy restriction. This effect was accompanied by the maintenance of insulin sensitivity improvement. Lastly, 20-hydroxyecdysone bioavailability measurements in mice allowed its plasma level quantification and the identification of metabolites whose role is still to be identified. These results show a potential benefit of the quinoa extract and its active principle, 20-hydroxyecdysone, on weight and adipose mass stabilization following weight loss. More studies are required to characterize further these effects.
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Anne-Sophie Foucault. Effets d'un extrait de quinoa enrichi en 20-hydroxyecdysone dans un modèle d'obésité nutritionnelle : application clinique. Médecine humaine et pathologie. AgroParisTech, 2012. Français. ⟨NNT : 2012AGPT0041⟩. ⟨pastel-00998299⟩

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