His-Gpx3 et des mutants cystéines de, p.156 ,
Protocole d'extraction TCA permettant de visualiser l'état redox de myc-Yap1 et de ,
Annexe 2 Article 1, pp.5157-66, 0197. ,
Annexe 3 Article 2, Cell, 2002. ,
Homeostatic regulation of intracellular hydrogen peroxide concentration in aerobically growing Escherichia coli., Journal of Bacteriology, vol.179, issue.2, pp.382-390, 1997. ,
DOI : 10.1128/jb.179.2.382-388.1997
Inducible repair of oxidative DNA damage in Escherichia coli, Nature, vol.193, issue.5925, pp.466-474, 1983. ,
DOI : 10.1038/304466a0
Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium, Cell, vol.41, issue.3, pp.41-753, 1985. ,
DOI : 10.1016/S0092-8674(85)80056-8
Inducibility of the response of yeast cells to peroxide stress, Journal of General Microbiology, vol.138, issue.2, pp.329-335, 1992. ,
DOI : 10.1099/00221287-138-2-329
Saccharomyces cerevisiae has distinct adaptive responses to both hydrogen peroxide and menadione., Journal of Bacteriology, vol.174, issue.20, pp.6678-81, 1992. ,
DOI : 10.1128/jb.174.20.6678-6681.1992
Saccharomyces cerevisiae has an inducible response to menadione Which differs from that to hydrogen peroxide, J ,
A global response induced in Escherichia coli by redox-cycling agents overlaps with that induced by peroxide stress., Journal of Bacteriology, vol.171, issue.7, pp.171-3933, 1989. ,
DOI : 10.1128/jb.171.7.3933-3939.1989
Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes, Process Citation], pp.4241-57, 2000. ,
DOI : 10.1091/mbc.11.12.4241
The H2O2 Stimulon in Saccharomyces cerevisiae, Journal of Biological Chemistry, vol.273, issue.35, pp.22480-22489, 1998. ,
DOI : 10.1074/jbc.273.35.22480
Genome-Wide Transcriptional Profiling of the Escherichia coli Responses to Superoxide Stress and Sodium Salicylate, Journal of Bacteriology, vol.183, issue.13 ,
DOI : 10.1128/JB.183.13.3890-3902.2001
DNA Microarray-Mediated Transcriptional Profiling of the Escherichia coli Response to Hydrogen Peroxide, Journal of Bacteriology, vol.183, issue.15, pp.183-4562, 2001. ,
DOI : 10.1128/JB.183.15.4562-4570.2001
Isolation of superoxide dismutase mutants in Escherichia coli: is superoxide dismutase necessary for aerobic life, Embo J, vol.5, issue.3, pp.623-653, 1986. ,
O2-dependent methionine auxotrophy in Cu,Zn superoxide dismutase-deficient mutants of Saccharomyces cerevisiae., Journal of Bacteriology, vol.172, issue.4, pp.1840-1845, 1990. ,
DOI : 10.1128/jb.172.4.1840-1845.1990
Null mutants of Saccharomyces cerevisiae Cu,Zn superoxide dismutase: characterization and spontaneous mutation rates., Journal of Bacteriology, vol.173, issue.18, pp.173-5918, 1991. ,
DOI : 10.1128/jb.173.18.5918-5920.1991
Is hydroxyl radical generated by the Fenton reaction in vivo?, Biochemical and Biophysical Research Communications, vol.130, issue.2, pp.533-542, 1985. ,
DOI : 10.1016/0006-291X(85)90449-8
Superoxide dismutase, oxidative stress, and cell metabolism, Curr Top Cell Regul, vol.36, pp.117-149, 2000. ,
DOI : 10.1016/S0070-2137(01)80005-4
Yeast Lacking Superoxide Dismutase(s) Show Elevated Levels of "Free Iron" as Measured by Whole Cell Electron Paramagnetic Resonance, Journal of Biological Chemistry, vol.275, issue.38, pp.275-29187, 2000. ,
DOI : 10.1074/jbc.M004239200
Superoxide accelerates DNA damage by elevating free-iron levels, Proceedings of the National Academy of Sciences, vol.295, issue.2, pp.93-13635, 1996. ,
DOI : 10.1016/0003-9861(92)90513-V
Growth in iron-enriched medium partially compensates Escherichia coli for the lack of manganese and iron superoxide dismutase, J Biol Chem, issue.17, pp.273-10313, 1998. ,
Yeast Lacking Cu-Zn Superoxide Dismutase Show Altered Iron Homeostasis. ROLE OF OXIDATIVE STRESS IN IRON METABOLISM, Journal of Biological Chemistry, vol.275, issue.16, pp.275-11645, 2000. ,
DOI : 10.1074/jbc.275.16.11645
Oxidative Stress and Iron Are Implicated in Fragmenting Vacuoles of Saccharomyces cerevisiae Lacking Cu,Zn-Superoxide Dismutase, Journal of Biological Chemistry, vol.274, issue.39, pp.274-27590, 1999. ,
DOI : 10.1074/jbc.274.39.27590
Isolation of catalase-deficient Escherichia coli mutants and genetic mapping of katE, a locus that affects catalase activity, J Bacteriol, vol.157, issue.2, pp.622-628, 1984. ,
Genetic mapping of katG, a locus that affects synthesis of the bifunctional catalase-peroxidase hydroperoxidase I in Escherichia coli, J Bacteriol, vol.162, issue.2, pp.661-668, 1985. ,
Nucleotide sequence of the Saccharomyces cerevisiae CTT1 gene and deduced amino-acid sequence of yeast catalase T, European Journal of Biochemistry, vol.99, issue.3, pp.487-90, 1986. ,
DOI : 10.1016/0022-2836(83)90041-4
Sequence of the Saccharomyces cerevisiae CTA1 gene and amino acid sequence of catalase A derived from it, Eur J Biochem, vol.176, issue.1, pp.159-63, 1988. ,
Roles for the two cysteine residues of AhpC in catalysis of peroxide reduction by alkyl hydroperoxide reductase from Salmonella typhimurium, Biochemistry, issue.43, pp.36-13349, 1997. ,
Diversity of glutathione peroxidases, Methods Enzymol, vol.252, pp.38-53, 1995. ,
Thioredoxin, Annual Review of Biochemistry, vol.54, issue.1, pp.237-71, 1985. ,
DOI : 10.1146/annurev.bi.54.070185.001321
URL : https://hal.archives-ouvertes.fr/hal-00188911
[21] Thioredoxin and thioredoxin reductase, Methods Enzymol, vol.252, pp.199-208, 1995. ,
DOI : 10.1016/0076-6879(95)52023-6
Thioredoxin-dependent peroxyde reductase from yeast, J Biol Chem, vol.269, pp.27670-27678, 1994. ,
Glutathione is an essential metabolite required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae, Curr Genet, issue.6, pp.29-511, 1996. ,
A short review on the role of glutathione in the response of yeasts to nutritional, environmental, and oxidative stresses, Enzyme and Microbial Technology, vol.26, issue.9-10, pp.9-10, 2000. ,
DOI : 10.1016/S0141-0229(00)00165-4
[29] Glutaredoxin, Methods Enzymol, vol.252, pp.283-92, 1995. ,
DOI : 10.1016/0076-6879(95)52031-7
The Yeast Glutaredoxins Are Active as Glutathione Peroxidases, Journal of Biological Chemistry, vol.277, issue.19, pp.16712-16719, 2002. ,
DOI : 10.1074/jbc.M111686200
Redox Potentials of Glutaredoxins and Other Thiol-Disulfide Oxidoreductases of the Thioredoxin Superfamily Determined by Direct Protein-Protein Redox Equilibria, Journal of Biological Chemistry, vol.272, issue.49, pp.272-30780, 1997. ,
DOI : 10.1074/jbc.272.49.30780
A Genetic Investigation of the Essential Role of Glutathione: MUTATIONS IN THE PROLINE BIOSYNTHESIS PATHWAY ARE THE ONLY SUPPRESSORS OF GLUTATHIONE AUXOTROPHY IN YEAST, Journal of Biological Chemistry, vol.276, issue.10, 2000. ,
DOI : 10.1074/jbc.M009814200
A thiol-specific antioxidant and sequence homology to various proteins of unknown function, Biofactors, vol.4, pp.3-4, 1994. ,
Dimerization of thiol-specific antioxidant and the essential role of cysteine 47., Proc. Natl. Acad. Sci. USA, pp.7022-7026, 1994. ,
DOI : 10.1073/pnas.91.15.7022
Removal of hydrogen peroxide by thiol-specific antioxidant enzyme (TSA) is involved with its antioxidant properties, J. biol. Chem, issue.271, pp.15315-15321, 1996. ,
Role of thioredoxins in the response of Saccharomyces cerevisiae to oxidative stress induced by hydroperoxides, Molecular Microbiology, vol.43, issue.4, pp.993-1003, 2002. ,
DOI : 10.1074/jbc.274.28.19714
Alkyl hydroperoxide reductase from Salmonella typhimurium ,
Distinct Physiological Functions of Thiol Peroxidase Isoenzymes in Saccharomyces cerevisiae, Journal of Biological Chemistry, vol.275, issue.8, pp.5723-5755, 2000. ,
DOI : 10.1074/jbc.275.8.5723
A New Antioxidant with Alkyl Hydroperoxide Defense Properties in Yeast, Journal of Biological Chemistry, vol.274, issue.8 ,
DOI : 10.1074/jbc.274.8.4537
Cooperation of Yeast Peroxiredoxins Tsa1p and Tsa2p in the Cellular Defense against Oxidative and Nitrosative Stress, Journal of Biological Chemistry, vol.277, issue.7, pp.5385-94, 2002. ,
DOI : 10.1074/jbc.M106846200
Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins., Genes & Development, vol.3, issue.3, pp.283-92, 1989. ,
DOI : 10.1101/gad.3.3.283
GSH1, which encodes gamma-glutamylcysteine synthetase, is a target gene for yAP-1 transcriptional regulation., Molecular and Cellular Biology, vol.14, issue.9, pp.5832-5841, 1994. ,
DOI : 10.1128/MCB.14.9.5832
Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions., Molecular and Cellular Biology, vol.17, issue.12 ,
DOI : 10.1128/MCB.17.12.6982
The response regulator-like protein ,
SKN7, a yeast multicopy suppressor of a mutation affecting cell wall beta-glucan assembly, encodes a product with domains homologous to prokaryotic two-component regulators and to heat shock transcription factors., Journal of Bacteriology, vol.175, issue.21, pp.6908-6915, 1993. ,
DOI : 10.1128/jb.175.21.6908-6915.1993
Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae., Proceedings of the National Academy of Sciences, vol.93, issue.12 ,
DOI : 10.1073/pnas.93.12.5777
The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stressresponse element (STRE), EMBO J, vol.15, pp.227-2235, 1996. ,
The control of the yeast H2O2 response by the Msn2/4 transcription factors, Molecular Microbiology, vol.14, issue.1, pp.233-274, 2002. ,
DOI : 10.1016/S0006-2952(99)00289-0
Transcriptional regulation of the Escherichia coli oxyR gene as a function of cell growth., Journal of Bacteriology, vol.179, issue.19, pp.179-6181, 1997. ,
DOI : 10.1128/jb.179.19.6181-6186.1997
In vivo transcription of the Escherichia coli oxyR regulon as a function of growth phase and in response to oxidative stress, J Bacteriol, vol.181, issue.9, pp.2759-64, 1999. ,
Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation, Science, vol.248, issue.4952, pp.189-194, 1990. ,
DOI : 10.1126/science.2183352
Mutational analysis of the redox-sensitive transcriptional regulator OxyR: regions important for oxidation and transcriptional activation., Journal of Bacteriology, vol.177, issue.5, pp.1275-1284, 1995. ,
DOI : 10.1128/jb.177.5.1275-1284.1995
Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation, Science, vol.279, issue.5357, pp.1718-1721, 1998. ,
DOI : 10.1126/science.279.5357.1718
Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol--disulfide status, Proceedings of the National Academy of Sciences, vol.179, issue.2, pp.96-6161, 1999. ,
DOI : 10.1016/S0092-8674(00)80547-4
Structural Basis of the Redox Switch in the OxyR Transcription Factor, Cell, vol.105, issue.1, pp.103-116, 2001. ,
DOI : 10.1016/S0092-8674(01)00300-2
OxyR, Cell, vol.109, issue.3, pp.383-96, 2002. ,
DOI : 10.1016/S0092-8674(02)00723-7
URL : http://doi.org/10.1016/s0092-8674(02)00723-7
The Redox-Sensitive Transcriptional Activator OxyR Regulates the Peroxide Response Regulon in the Obligate Anaerobe Bacteroides fragilis, Journal of Bacteriology, vol.182, issue.18, pp.182-5059, 2000. ,
DOI : 10.1128/JB.182.18.5059-5069.2000
Mutations in oxyR Resulting in Peroxide Resistance in Xanthomonas campestris, Journal of Bacteriology, vol.182, issue.13, pp.3846-3855, 2000. ,
DOI : 10.1128/JB.182.13.3846-3849.2000
Identification of Brucella abortus OxyR and Its Role in Control of Catalase Expression, Journal of Bacteriology, vol.182, issue.19, pp.182-5631, 2000. ,
DOI : 10.1128/JB.182.19.5631-5633.2000
Bacillus subtilis contains multiple Fur homologues: identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors, Molecular Microbiology, vol.29, issue.1, pp.189-98, 1998. ,
DOI : 10.1126/science.279.5357.1718
Roles of metal ions and hydrogen peroxide in modulating the interaction of the Bacillus subtilis PerR peroxide regulon repressor with operator DNA, Molecular Microbiology, vol.279, issue.4, pp.849-59, 2001. ,
DOI : 10.1046/j.1365-2958.2001.02543.x
Regulation of the Bacillus subtilis fur and perR Genes by PerR: Not All Members of the PerR Regulon Are Peroxide Inducible, Journal of Bacteriology, vol.184, issue.12, pp.184-3276, 2002. ,
DOI : 10.1128/JB.184.12.3276-3286.2002
OhrR Is a Repressor of ohrA, a Key Organic Hydroperoxide Resistance Determinant in Bacillus subtilis, Journal of Bacteriology, vol.183, issue.14, pp.183-4134, 2001. ,
DOI : 10.1128/JB.183.14.4134-4141.2001
The OhrR repressor senses organic hydroperoxides by reversible formation of a cysteine-sulfenic acid derivative, Proceedings of the National Academy of Sciences, vol.179, issue.23, pp.99-6690, 2002. ,
DOI : 10.1074/jbc.M006137200
An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein, Embo J, vol.13, issue.1, pp.138-184, 1994. ,
Binuclear [2Fe-2S] Clusters in the Escherichia coli SoxR Protein and Role of the Metal Centers in Transcription, Journal of Biological Chemistry, vol.270, issue.36, pp.270-20908, 1995. ,
DOI : 10.1074/jbc.270.36.20908
Cysteine-to-Alanine Replacements in the Escherichia Coli SoxR Protein and the Role of the [2Fe-2S] Centers in Transcriptional Activation, Nucleic Acids Research, vol.25, issue.8, pp.25-1469, 1997. ,
DOI : 10.1093/nar/25.8.1469
SoxR, a [2Fe-2S] transcription factor, is active only in its oxidized form., Proceedings of the National Academy of Sciences, vol.93, issue.19, pp.93-10094, 1996. ,
DOI : 10.1073/pnas.93.19.10094
The Redox State of the [2Fe-2S] Clusters in SoxR Protein Regulates Its Activity as a Transcription Factor, Journal of Biological Chemistry, vol.271, issue.52, pp.271-33173, 1996. ,
DOI : 10.1074/jbc.271.52.33173
In vivo kinetics of a redox-regulated transcriptional switch, Proceedings of the National Academy of Sciences, vol.21, issue.5 ,
DOI : 10.1016/0968-0004(96)10024-4
Regulation of the soxRS Oxidative Stress Regulon: REVERSIBLE OXIDATION OF THE Fe-S CENTERS OF SoxR IN VIVO, Journal of Biological Chemistry, vol.272, issue.8, pp.272-5082, 1997. ,
DOI : 10.1074/jbc.272.8.5082
Glutathione-mediated destabilization in vitro of [2Fe-2S] centers in the SoxR regulatory protein., Proceedings of the National Academy of Sciences, vol.93, issue.18, pp.93-9449, 1996. ,
DOI : 10.1073/pnas.93.18.9449
Activation of SoxR-dependent transcription in vitro by noncatalytic or NifS-mediated assembly of [2Fe-2S] clusters into apo-SoxR, J Biol Chem, issue.13, pp.271-7269, 1996. ,
Spacing of promoter elements regulates the basal expression of the soxS gene and converts SoxR from a transcriptional activator into a repressor, The EMBO Journal, vol.16, issue.5, pp.1056-65, 1997. ,
DOI : 10.1093/emboj/16.5.1056
Activation of SoxR by Overproduction of Desulfoferrodoxin: Multiple Ways To Induce the soxRS Regulon, Journal of Bacteriology, vol.182, issue.6, pp.1761-1764, 2000. ,
DOI : 10.1128/JB.182.6.1761-1763.2000
Yap1p Activates Gene Transcription in an Oxidant-Specific Fashion, Molecular and Cellular Biology, vol.19, issue.12, pp.8302-8313, 1999. ,
DOI : 10.1128/MCB.19.12.8302
H 2 O 2 sensing through oxidation of the Yap1 transcription factor, EMBO J, pp.19-5157, 2000. ,
Mutational analysis of Yap1 protein, an AP-1-like transcriptional activator of Saccharomyces cerevisiae, FEBS Lett, issue.416, pp.339-343, 1997. ,
Chemistry of Sulfenic Acids. 4. the first Direct Evidence for the Involvement of Sulfenic Acids in the Oxidation of Thiols, pp.7016-7018, 1981. ,
Protein-sulfenic acid stabilization and function in enzyme catalysis and gene regulation, Faseb J, issue.715, pp.1483-90, 1993. ,
Reactivity and Ionization of the Active Site Cysteine Residues of DsbA, a Protein Required for Disulfide Bond Formation in vivo, Biochemistry, vol.33, issue.19, pp.33-5974, 1994. ,
DOI : 10.1021/bi00185a039
Phospholipid hydroperoxide glutathione peroxidase (PHGPx): more than an antioxidant enzyme?, Biomed Environ Sci, vol.10, issue.2-3, pp.327-359, 1997. ,
Dual Function of the Selenoprotein PHGPx During Sperm Maturation, Science, vol.285, issue.5432 ,
DOI : 10.1126/science.285.5432.1393
Distribution and Possible Novel Role of Phospholipid Hydroperoxide Glutathione Peroxidase in Rat Epididymal Spermatozoa1, Biology of Reproduction, vol.57, issue.6, pp.1502-1510, 1997. ,
DOI : 10.1095/biolreprod57.6.1502
PHGPx and spermatogenesis, BioFactors, vol.17, issue.2, pp.213-235, 2001. ,
DOI : 10.1002/biof.5520140127
Identification of a New Type of Mammalian Peroxiredoxin That Forms an Intramolecular Disulfide as a Reaction Intermediate, Journal of Biological Chemistry, vol.275, issue.27, pp.275-20346, 2000. ,
DOI : 10.1074/jbc.M001943200
A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growth., Molecular Biology of the Cell, vol.7, issue.11, pp.1805-1818, 1996. ,
DOI : 10.1091/mbc.7.11.1805
Thioredoxin Deficiency Causes the Constitutive Activation of Yap1, an AP-1-like Transcription Factor in Saccharomyces cerevisiae, Journal of Biological Chemistry, vol.274, issue.40, pp.28459-28465, 1999. ,
DOI : 10.1074/jbc.274.40.28459
The Refined Structure of the Selenoenzyme Glutathione Peroxidase at 0.2-nm Resolution, European Journal of Biochemistry, vol.6, issue.1, pp.51-69, 1983. ,
DOI : 10.1016/0005-2760(73)90145-8
The crystal structure of seleno-glutathione peroxidase from human plasma at 2.9 ?? resolution, Journal of Molecular Biology, vol.268, issue.5, pp.869-85, 1997. ,
DOI : 10.1006/jmbi.1997.1005
Oxidative stress, Sies, pp.91-111, 1985. ,
URL : https://hal.archives-ouvertes.fr/hal-00562814
Potentiation of oxygen toxicity by menadione in Saccharomyces cerevisiae, Biochimie, vol.65, issue.8-9, pp.501-513, 1983. ,
DOI : 10.1016/S0300-9084(83)80132-1
Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes, Archives of Biochemistry and Biophysics, vol.235, issue.2, pp.334-376, 1984. ,
DOI : 10.1016/0003-9861(84)90206-6
Formation of disulfides with diamide, Methods Enzymol, issue.143, pp.264-269, 1987. ,
DOI : 10.1016/0076-6879(87)43050-4
Diethylmaleate activates the transcription factor Pap1 by covalent modification of critical cysteine residues, Molecular Microbiology, vol.269, issue.1, pp.243-54, 2002. ,
DOI : 10.1126/science.279.5357.1718
Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra-and intermolecular cross-linking reaction, J Biol Chem, vol.268, issue.9, pp.6388-93, 1993. ,
Characterization of Escherichia coli Null Mutants for Glutaredoxin 2, Journal of Biological Chemistry, vol.277, issue.13, pp.10861-10869, 2002. ,
DOI : 10.1074/jbc.M111024200
Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase??Sty1/Spc1, Genes & Development, vol.12, issue.10, pp.12-1453, 1998. ,
DOI : 10.1101/gad.12.10.1453
Characterization of an AP-1-like transcription factor that mediates an oxidative stress response in Kluyveromyces lactis, Molecular and General Genetics MGG, vol.257, issue.1, pp.62-70, 1997. ,
DOI : 10.1007/s004380050624
Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels, Analytical Chemistry, vol.68, issue.5, pp.850-858, 1996. ,
DOI : 10.1021/ac950914h
GSHJ_YEAST(GPX3) 116 --MLGLRGIKWNFEKFLVDKKGKVYERYSSLTKPS--SLSETIEELLKEVE-163 GSHI_YEAST(GPX2) 115 --LLGFKGIKWNFEKFLVDSNGKVVQRFSSLTKPS--SLDQEIQSLLSK---160 GSHJ_SCHPO 115, p.158 ,