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Colloïdes magnétiques: auto-organisation et applications biologiques

Abstract : This manuscript introduces the study of self-assembled magnetic latexes. First, we present a method to obtain magnetic filaments made of magnetic particles and linkers. These objects provide a new micromechanical approach to probe bending rigidity at the molecular scale. Under a magnetic field, they adopt a hairpin configuration. Measuring the hairpin curvature as a function of the field intensity and the linker length allows us to deduce the linker bending rigidity. Second, these filaments can be self-organized in a microchannel to provide a new matrix for cell sorting. Control of the spacing between filaments, anchoring, and functionnalization with specific antibodies are described, together with the feasability for performing cell chromatography with the system. These new objects introduce a wide field of very promising biomedical applications e.g. for lab-on-chip devices.
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https://pastel.archives-ouvertes.fr/tel-00008382
Contributor : Cécile Goubault <>
Submitted on : Monday, February 7, 2005 - 4:49:51 PM
Last modification on : Saturday, September 26, 2020 - 11:44:06 PM
Long-term archiving on: : Friday, April 2, 2010 - 9:03:03 PM

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  • HAL Id : tel-00008382, version 1

Citation

Cécile Goubault. Colloïdes magnétiques: auto-organisation et applications biologiques. Biophysique [physics.bio-ph]. Université Pierre et Marie Curie - Paris VI, 2004. Français. ⟨tel-00008382⟩

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