Modélisation biomécanique et étude de la fonctionnalisation d’un implant personnalisé de reconstruction mandibulaire en titane poreux

Abstract : Several articles report on the regeneration of bone defects using synthetic porous structures mimicking bone micro-architecture. Porous implants exhibiting mechanical properties close to that of bone tissue with enhanced osseointegration ability can be manufactured by means of selective laser melting of titanium. However, bone growth into the pores of such implant could be limited due to oversized elastic properties. We implemented an experimental study with ewes to assess the influence of the overall stiffness of these implants on bone ingrowth in critical-size mandibular defects. Fully load-bearing porous and control implants of varying overall stiffness were developed and implanted in two groups of six ewes. Bone ingrowth was assessed by mechanical characterization of bone-implant interfaces and by the measurement of the newly formed bone volume using micro-CT imaging. Higher bone ingrowth was identified in porous implants compared to control implants. Low-stiffness porous implants exhibited significantly higher bone ingrowth as compared to porous implants with stiffness closer to that of the missing bone. A finite elements model was developed to improve bone fixation of the implant and load transfer through the bone-implant interfaces.
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Thomas Schouman. Modélisation biomécanique et étude de la fonctionnalisation d’un implant personnalisé de reconstruction mandibulaire en titane poreux. Biomécanique [physics.med-ph]. Ecole nationale supérieure d'arts et métiers - ENSAM, 2016. Français. ⟨NNT : 2016ENAM0065⟩. ⟨tel-01514161⟩

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