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Development of new reactions of organic synthesis catalyzed by gold and copper

Abstract : This manuscript presents the development of gold- and copper-catalyzed methods for the synthesis of heterocyclic compounds and trifluoromethylated products.Firstly, a gold-catalyzed synthesis of trifluoromethyl allenes was developed, relying on a 1,5 hydride shift. This method allows to access, in a very efficient and selective way, a large range of perfluoroalkylated allenes, of which the synthetic potential was also demonstrated.Afterwards, the catalytic power of gold was then used in a synthesis of 2H-1,3-oxazines, relying on a 6-endo type cyclization of azide-yne substrates. This methods allows to access, in very mild condition, an unprecedently large range of polysubstituted oxazines in excellent yields.Finally, a method for the copper-catalyzed radical hydrofunctionalization of alkenols was developed. The strategy involved relies on a 1,5 hydrogen abstraction, in which a benzyloxy moiety plays the role of the hydrogen donor.
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Submitted on : Wednesday, December 13, 2017 - 9:25:07 PM
Last modification on : Friday, January 7, 2022 - 3:47:22 AM


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  • HAL Id : tel-01663461, version 1


Geoffroy Lonca. Development of new reactions of organic synthesis catalyzed by gold and copper. Organic chemistry. Université Paris Saclay (COmUE), 2017. English. ⟨NNT : 2017SACLX057⟩. ⟨tel-01663461⟩



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