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A mathematical approach to embryonic morphogenesis based on spatio-temporal cell lineages

Abstract : This thesis approaches morphogenetic processes in the early embryogenesis of verte-brates through the mathematical and physical study of spatio-temporal cell lineagesreconstructed from in vivo 3D+time images. Our methodology is based on a complexsystems representation of the embryo, with the interaction between levels of organiza-tion and the formal analysis of cell displacements in space and time. We designed andimplemented an original methodology to identify in cell lineages the formation of com-partments in consistency with anatomical landmarks and the organization of presump-tive organs. In addition, we proposed a strategy to infer the underlying biomechanicalforces. We also delivered a user-friendly computer interface, first deployed for usingour methodology but also designed to be extensible and versatile, which aims to bea common ground for biologists, mathematicians, physicists and computer scientistsinvestigating morphogenetic processes in living systems.
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Submitted on : Monday, January 22, 2018 - 2:32:01 PM
Last modification on : Tuesday, September 29, 2020 - 5:16:19 AM
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  • HAL Id : tel-01689773, version 1


Juan Raphael Diaz Simoes. A mathematical approach to embryonic morphogenesis based on spatio-temporal cell lineages. Bioinformatics [q-bio.QM]. Université Paris Saclay (COmUE), 2017. English. ⟨NNT : 2017SACLX065⟩. ⟨tel-01689773⟩



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