Application of Xanthates to the Synthesis of Azaindanes and to the C-H Functionalization of Heteroaromatics

Abstract : In this thesis, we have undertaken an adventure to discover wider application of xanthate chemistry in the construction of fused cycles and direct alkylation of heteroarenes. In Chapter II, we have tackled the problem of preparation of azaindane by taking advantage of the ability of xanthates to mediate both intermolecular addition and intramolecular cyclisation. In Chapter III, an unprecedented investigation into the direct functionalization of pyrazines was described, leading to highly functionalized pyrazines in good yields and good regioselectivity. Finally, in Chapter IV, we have developed a method for the methylation and fluoromethylation of heteroarenes.
Document type :
Theses
Complete list of metadatas

Cited literature [15 references]  Display  Hide  Download

https://pastel.archives-ouvertes.fr/tel-01712214
Contributor : Abes Star <>
Submitted on : Monday, February 19, 2018 - 11:42:26 AM
Last modification on : Friday, May 17, 2019 - 9:02:48 AM
Long-term archiving on: Tuesday, May 8, 2018 - 2:07:05 AM

File

65248_HUANG_2017_archivage.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01712214, version 1

Citation

Qi Huang. Application of Xanthates to the Synthesis of Azaindanes and to the C-H Functionalization of Heteroaromatics. Organic chemistry. Université Paris-Saclay, 2017. English. ⟨NNT : 2017SACLX114⟩. ⟨tel-01712214⟩

Share

Metrics

Record views

432

Files downloads

362