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Theses

Développement, modélisation et caractérisation d'une maille innovante réalisée en fabrication additive pour les grands défauts osseux

Abstract : The work detailed in this thesis is about a titanium 3D printed mesh for large bone defects. Large bone defects are often due to surgical resections, performed after a cancer or an infection. When the defect reach a critical size, bone regeneration is impossible and it often leads to the loss of function. When it happened, the wound need to be cured using reconstructive surgery. The mandibular reconstruction is one of the most performed reconstructive surgery. Nowadays, we reconstruct the mandible with the fibula free flap technique, which require huge amount of time and resources for mixed results (around 10% failure rate). Based on the international literature, we developed a titanium 3D printed mesh to replace the fibula autograft and limit its side effect while offering to mesenchymal cells optimal growing environment. On the mechanical point of view, this environment requires to decrease the titanium initial rigidity from 110GPa to a range between 0.1 and 1GPa. In order to achieve that goal, we have developed a design methodology that lead us to innovation. We developed a load restauration system that allow us to combine low rigidity and high resistance. In order to find the final design, we used finite element modeling. Then, the final design have been tested mechanically in compression, traction and flexion. Because most of the requirements were reached, we designed an animal study which should take place in the next years. Eventually, we discovered some limitation for metallic 3D printing, essentially due to unsupported areas required for the load restauration. This innovative mesh is today optimized in order to be rapidly given to patients in the need.
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https://pastel.archives-ouvertes.fr/tel-01760543
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Submitted on : Friday, April 6, 2018 - 2:26:10 PM
Last modification on : Tuesday, May 19, 2020 - 5:44:45 AM

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  • HAL Id : tel-01760543, version 1

Citation

Jérémy Adam. Développement, modélisation et caractérisation d'une maille innovante réalisée en fabrication additive pour les grands défauts osseux. Biomécanique [physics.med-ph]. Ecole nationale supérieure d'arts et métiers - ENSAM, 2017. Français. ⟨NNT : 2017ENAM0068⟩. ⟨tel-01760543⟩

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