Conception d'un outil d'évaluation de l'acceptabilité des médicaments

Abstract : Medicine development must satisfy efficiency and safety objectives. Patient compliance with physician’s prescription is an essential condition to achieve these objectives. Patient acceptability of a medicine improves patient compliance and thus ensures drug success, in particular in paediatric and geriatric populations. Acceptability could be defined as the overall ability and willingness of the patient to use, and its care giver to administer, the medicine as intended. Acceptability is driven by the users’ and the products’ characteristics. Thus, designers have to consider the specific features of the targeted users to develop a medicine with the most adapted characteristics to reach the best acceptability. Evaluation of the acceptability should be an integral part of pharmaceutical and clinical development. Today, knowledge on this complex phenomenon is still fragmented and there are no internationally agreed methods available to assess this multidimensional concept. This document sets out the development of a validated tool, the acceptability reference framework, providing standardized medicines acceptability evaluation and relevant knowledge usable by designers from the early stage of medicine development. As this research was carried out in a medical field, we propose a formalized methodology transferable to other domains.
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Thibault Vallet. Conception d'un outil d'évaluation de l'acceptabilité des médicaments. Génie des procédés. Ecole nationale supérieure d'arts et métiers - ENSAM, 2017. Français. ⟨NNT : 2017ENAM0048⟩. ⟨tel-01762953⟩

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