R. Développer-le, 180 5.3.1. Mesures observées, p.183

L. Adams, S. Craig, E. Mmbaga, H. Naburi, T. Lahey et al., Children???s Medicines in Tanzania: A National Survey of Administration Practices and Preferences, PLoS ONE, vol.7, issue.5, p.58303, 2013.
DOI : 10.1371/journal.pone.0058303.s003

A. Nf, V09-500 -Analyse sensorielle -Méthodologie -Directives générales pour des réalisations d'épreuves hédoniques effectuées avec des consommateurs dans un espace contrôlé. Association, 2012.

A. Nf, V09-500 -Analyse sensorielle -Méthodologie -Directives générales pour des réalisations d'épreuves hédoniques effectuées avec des consommateurs dans un espace contrôlé. Association Française de Normalisation, 2012.

G. Akram and A. Mullen, Paediatric nurses' knowledge and practice of mixing medication into foodstuff, International Journal of Pharmacy Practice, vol.30, issue.3
DOI : 10.1016/S0149-2918(08)80054-9

N. Almenrader, M. Passariello, B. Coccetti, R. Haiberger, and P. Pietropaoli, Steal-induction after clonidine premedication: a comparison of the oral and nasal route, Pediatric Anesthesia, vol.2, issue.3, pp.230-234, 2007.
DOI : 10.1111/j.1399-6576.2006.00940.x

B. Ambuel, K. Hamlett, C. Marx, and J. Blumer, Assessing Distress in Pediatric Intensive Care Environments: The COMFORT Scale, Journal of Pediatric Psychology, vol.17, issue.1, pp.95-109, 1992.
DOI : 10.1093/jpepsy/17.1.95

S. Anand and A. Büchner, Decision support using data mining: Financial Times Management, 1998.

V. Anand, M. Kataria, V. Kukkar, V. Saharan, and P. Choudhury, The latest trends in the taste assessment of pharmaceuticals, Drug Discovery Today, vol.12, issue.5-6, pp.5-6257, 2007.
DOI : 10.1016/j.drudis.2007.01.010

V. Anand, V. Kharb, M. Kataria, V. Kukka, and P. Choudhury, Taste assessment trials for sensory analysis of oral pharmaceutical products, Pak J Pharm Sci, vol.21, issue.4, pp.438-50, 2008.

A. Aoussat, La pertinence en innovation: nécessité d'une approche plurielle. Laboratoire Conception de Produits et Innovation, 1990.

A. Aoussat, H. Christofol, L. Coq, and M. , The new product design ??? a transverse approach, Journal of Engineering Design, vol.5, issue.4, pp.399-417, 2000.
DOI : 10.1016/S0007-8506(07)61126-3

R. Arbuckle, L. Abetz, J. Durmer, A. Ivanenko, J. Owens et al., Development of the Pediatric Restless Legs Syndrome Severity Scale (P-RLS-SS)??: A patient-reported outcome measure of pediatric RLS symptoms and impact, Sleep Medicine, vol.11, issue.9, pp.897-906, 2010.
DOI : 10.1016/j.sleep.2010.03.016

R. Arbuckle and L. Abetz-webb, ???Not Just Little Adults???: Qualitative Methods to Support the Development of Pediatric Patient-Reported Outcomes, The Patient - Patient-Centered Outcomes Research, vol.44, issue.4, pp.143-59, 2013.
DOI : 10.1046/j.1528-1157.2003.46302.x

B. Arnould, H. Gilet, D. Patrick, and C. Acquadro, Item Reduction, Scoring, and First Validation of the ACCEPTance by the Patients of their Treatment (ACCEPT??) Questionnaire, The Patient - Patient-Centered Outcomes Research, vol.30, issue.Suppl. 2, p.25, 2016.
DOI : 10.1086/313849

P. Atkin, T. Finnegan, S. Ogle, and G. Shenfield, Functional Ability of Patients to manage Medication Packaging: A Survey of Geriatric Inpatients, Age and Ageing, vol.23, issue.2, pp.113-119, 1994.
DOI : 10.1093/ageing/23.2.113

M. Atkinson, A. Sinha, S. Hass, S. Colman, R. Kumar et al., Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease, Health and Quality of Life Outcomes, vol.2, issue.1, p.12, 2004.
DOI : 10.1186/1477-7525-2-12

M. Atkinson, R. Kumar, J. Cappelleri, and S. Hass, Hierarchical Construct Validity of the Treatment Satisfaction Questionnaire for Medication (TSQM Version II) among Outpatient Pharmacy Consumers, Value in Health, vol.8, issue.1, pp.9-24, 2005.
DOI : 10.1111/j.1524-4733.2005.00066.x

M. Azermai, Dealing with behavioral and psychological symptoms of dementia: a general overview. Psychology research and behavior management, p.181, 2015.

R. Babbitt, J. Parrish, P. Brierley, and M. Kohr, Teaching Developmentally Disabled Children with Chronic Illness to Swallow Prescribed Capsules, Journal of Developmental & Behavioral Pediatrics, vol.12, issue.4, pp.229-264, 1991.
DOI : 10.1097/00004703-199108000-00003

D. Baguley, E. Lim, A. Bevan, A. Pallet, and S. Faust, Prescribing for children ??? taste and palatability affect adherence to antibiotics: a review, Archives of Disease in Childhood, vol.97, issue.3, pp.293-300, 2012.
DOI : 10.1136/archdischild-2011-300909

L. Bartoshuk and . Taste, Taste: Robust across the Age Span?, Annals of the New York Academy of Sciences, vol.14, issue.1 Nutrition and, pp.65-75, 1989.
DOI : 10.1126/science.173.4002.1103

H. Batchelor, R. Venables, J. Marriott, and T. Mills, The application of tribology in assessing texture perception of oral liquid medicines, International Journal of Pharmaceutics, vol.479, issue.2, pp.277-81, 2015.
DOI : 10.1016/j.ijpharm.2015.01.004

M. Beck, M. Cataldo, K. Slifer, V. Pulbrook, and J. Guhman, Teaching Children with Attention Deficit Hyperactivity Disorder (ADHD) and Autistic Disorder (AD) How to Swallow Pills, Clinical Pediatrics, vol.44, issue.6, pp.515-541, 2005.
DOI : 10.1207/s15326888chc1301_4

J. Bellis, J. Kirkham, S. Thiesen, E. Conroy, L. Bracken et al., Adverse drug reactions and off-label and unlicensed medicines in children: a nested case?control study of inpatients in a pediatric hospital, BMC Medicine, vol.13, issue.1, p.238, 2013.
DOI : 10.1186/1471-2431-13-81

J. Bernaud, Introduction à la psychométrie: Dunod, 2007.

M. Bharmal, K. Payne, M. Atkinson, M. Desrosiers, D. Morisky et al., Validation of an abbreviated Treatment Satisfaction Questionnaire for Medication (TSQM-9) among patients on antihypertensive medications. Health and quality of life outcomes, p.36, 2009.

M. Bhat, R. Jordt, M. Khan, C. Foley, and T. Gilbertson, Validation of a rat behavioral avoidance model from a drug delivery perspective, International Journal of Pharmaceutics, vol.303, issue.1-2, pp.31-37, 2005.
DOI : 10.1016/j.ijpharm.2005.06.015

A. Bianchetti, Evaluation de l'acceptabilité des formulations de calcium et vitamine D par des enfants, 2009.

L. Bigeard, The role of medication and sugars in pediatric dental patients, Dental Clinics of North America, vol.44, issue.3, pp.443-56, 2000.

V. Biyyala, A. Rumondor, K. Thompson, D. Harris, F. Flanagan et al., Novel solid oral dosage form in pediatric populations ??? Emphasis on minitablets, International Journal of Pharmaceutics, vol.511, issue.2, p.1145, 2016.
DOI : 10.1016/j.ijpharm.2016.06.101

J. Boateng, Drug Delivery Innovations to Address Global Health Challenges for Pediatric and Geriatric Populations (through improvements in patient compliance) Journal of Pharmaceutical Sciences, 2017.

I. Boots, R. Sukhai, R. Klein, R. Holl, J. Wit et al., Stimulation programs for pediatric drug research?do children really benefit? European journal of pediatrics, pp.849-55, 2007.

F. Bourgeois, M. Shannon, C. Valim, and K. Mandl, Adverse drug events in the outpatient setting: an 11-year national analysis, Pharmacoepidemiology and Drug Safety, vol.109, issue.2, pp.901-911, 2010.
DOI : 10.1016/S1553-7250(05)31050-6

A. Bowles, J. Keane, T. Ernest, D. Clapham, and C. Tuleu, Specific aspects of gastro-intestinal transit in children for drug delivery design, International Journal of Pharmaceutics, vol.395, issue.1-2, pp.37-43, 2010.
DOI : 10.1016/j.ijpharm.2010.04.048

M. Bradley and P. Lang, Measuring emotion: The self-assessment manikin and the semantic differential, Journal of Behavior Therapy and Experimental Psychiatry, vol.25, issue.1, pp.49-59, 1994.
DOI : 10.1016/0005-7916(94)90063-9

M. Braun-münker and F. Ecker, Ease of opening of blistered solid dosage forms in a senior citizens target group, International Journal of Pharmaceutics, vol.512, issue.2, pp.412-417, 2016.
DOI : 10.1016/j.ijpharm.2015.10.063

S. Bredenberg, D. Nyholm, S. Aquilonius, and C. Nyström, An automatic dose dispenser for microtablets???a new concept for individual dosage of drugs in tablet form, International Journal of Pharmaceutics, vol.261, issue.1-2, pp.137-183, 2003.
DOI : 10.1016/S0378-5173(03)00294-1

J. Breitkreutz and J. Boos, Paediatric and geriatric drug delivery, Expert Opinion on Drug Delivery, vol.67, issue.1, pp.37-45, 2007.
DOI : 10.1055/s-2005-870129

L. Broadman, L. Rice, and R. Hannallah, TESTING THE VALIDITY OF AN OBJECTIVE PAIN SCALE FOB INFANTS AND CHILDREN, Anesthesiology, vol.69, issue.Supplement, p.770, 1988.
DOI : 10.1097/00000542-198809010-00770

M. Brod, L. Tesler, and T. Christensen, Qualitative research and content validity: developing best practices based on science and experience, Quality of Life Research, vol.16, issue.4, pp.1263-78, 2009.
DOI : 10.4135/9781412984287

D. Brotherman, T. Bayraktaroglu, and R. Garofalo, Comparison of Ease of Swallowing of Dietary Supplement Products for Age-Related Eye Disease, Journal of the American Pharmacists Association, vol.44, issue.5, pp.587-93, 2004.
DOI : 10.1331/1544-3191.44.5.583.Brotherman

J. Brozek, G. Guyatt, and H. Schunemann, How a well-grounded minimal important difference can enhance transparency of labelling claims and improve interpretation of a patient reported outcome measure: Health Qual Life Outcomes, p.69, 2006.

S. Bryson, Patient-centred, administration friendly medicines for children ??? An evaluation of children???s preferences and how they impact medication adherence, International Journal of Pharmaceutics, vol.469, issue.2, pp.257-266, 2014.
DOI : 10.1016/j.ijpharm.2014.04.069

E. Burns and G. Mulley, Practical Problems with Eye-drops Among Elderly Ophthalmology Outpatients, Age and Ageing, vol.21, issue.3, pp.168-70, 1992.
DOI : 10.1093/ageing/21.3.168

T. Byrt, J. Bishop, and J. Carlin, Bias, prevalence and kappa, Journal of Clinical Epidemiology, vol.46, issue.5, pp.423-432, 1993.
DOI : 10.1016/0895-4356(93)90018-V

P. Cabena, P. Hadjinian, R. Stadler, J. Verhees, and A. Zanasi, Discovering data mining: from concept to implementation, 1998.

J. Cacioppo, G. Bernston, J. Larsen, . K. Poehlmann, and . Ito, The psychophysiology of emotion: Handbook of emotion, 2000.

G. Carnaby-mann and M. Crary, Pill Swallowing by Adults With Dysphagia, Archives of Otolaryngology???Head & Neck Surgery, vol.131, issue.11, pp.970-975, 2005.
DOI : 10.1001/archotol.131.11.970

M. Carrier, O. Garinot, and C. Vitzling, Stability and compatibility of tegaserod from crushed tablets mixed in beverages and foods. American journal of health-system pharmacy, p.61, 2004.

M. Caussin, W. Mourier, S. Philippe, C. Capet, M. Adam et al., L?????crasement des m??dicaments en g??riatrie??: une pratique ????artisanale???? avec de fr??quentes erreurs qui n??cessitait des recommandations, La Revue de M??decine Interne, vol.33, issue.10, pp.546-51, 2012.
DOI : 10.1016/j.revmed.2012.05.014

E. Chambers, Commentary: Conducting sensory research with children. journal of sensory studies, pp.90-92, 2005.

C. Chang and C. Chen, Applying decision tree and neural network to increase quality of dermatologic diagnosis, Expert Systems with Applications, vol.36, issue.2, pp.4035-4076, 2009.
DOI : 10.1016/j.eswa.2008.03.007

A. Chen, A. Resurreccion, and L. Paguio, Age appropriate hedonic scales to measure food preferences of young children. journal of sensory studies, pp.141-63, 1996.

J. Chevalier, Mesure de l'utilité attachée aux états de santé. Valorisation de l'index d'utilité EQ-5D et évolution de l'échelle actuelle en France, 2010.

I. Choonara and S. Conroy, Unlicensed and Off-Label Drug Use in Children, Drug Safety, vol.82, issue.1, pp.1-5, 2002.
DOI : 10.2165/00002018-200225010-00001

K. Cios, A. Teresinska, S. Konieczna, J. Potocka, and S. Sharma, A knowledge discovery approach to diagnosing myocardial perfusion, IEEE Engineering in Medicine and Biology Magazine, vol.19, issue.4, pp.17-25, 2000.
DOI : 10.1109/51.853478

I. Cohen, D. Joffe, K. Hummer, and A. Soluri, Ondansetron Oral Disintegrating Tablets: Acceptability and Efficacy in Children Undergoing Adenotonsillectomy, Anesthesia & Analgesia, vol.101, issue.1, pp.59-63, 2005.
DOI : 10.1213/01.ANE.0000154186.03161.35

M. Connolly, Inhaler Technique of Elderly Patients: Comparison of Metered-dose Inhalers and Large Volume Spacer Devices, Age and Ageing, vol.24, issue.3, pp.190-192, 1995.
DOI : 10.1093/ageing/24.3.190

S. Conroy, I. Choonara, P. Impicciatore, A. Mohn, H. Arnell et al., Survey of unlicensed and off label drug use in paediatric wards in European countries, BMJ, vol.320, issue.7227, pp.79-82, 2000.
DOI : 10.1136/bmj.320.7227.79

R. Contreras, C. Carson, and C. Pierce, A Novel Psychophysical Procedure for Bitter Taste Assessment in Rats, Chemical Senses, vol.20, issue.3, pp.305-317, 1995.
DOI : 10.1093/chemse/20.3.305

S. Craig, L. Adams, S. Spielberg, and B. Campbell, Pediatric therapeutics and medicine administration in resource-poor settings: A review of barriers and an agenda for interdisciplinary approaches to improving outcomes, Social Science & Medicine, vol.69, issue.11, pp.1681-90, 2009.
DOI : 10.1016/j.socscimed.2009.08.024

M. Crary, J. Humphrey, G. Carnaby-mann, R. Sambandam, L. Miller et al., Dysphagia, Nutrition, and Hydration in Ischemic Stroke Patients at Admission and Discharge from Acute Care, Dysphagia, vol.1, issue.1, pp.69-76, 2013.
DOI : 10.1007/s12028-004-0003-4

D. Czyzewski, N. Calles, R. Runyan, and M. Lopez, Teaching and maintaining pill swallowing in HIV-infected children, AIDS READER-NEW YORK, vol.10, issue.2, pp.88-95, 2000.

R. Dagan, P. Shvartzman, and Z. Liss, Variation in acceptance of common oral antibiotic suspensions, The Pediatric Infectious Disease Journal, vol.13, issue.8, pp.686-90, 1994.
DOI : 10.1097/00006454-199408000-00002

A. Damasio, Spinoza avait raison Joie et tristesse, le cerveau des émotions, Natures Sciences Sociétés, vol.13, pp.335-384, 2005.

R. Das, I. Turkoglu, and A. Sengur, Effective diagnosis of heart disease through neural networks ensembles, Expert Systems with Applications, vol.36, issue.4, pp.7675-80, 2009.
DOI : 10.1016/j.eswa.2008.09.013

E. Davies and C. Tuleu, Medicines for Children: A Matter of Taste, The Journal of Pediatrics, vol.153, issue.5, pp.599-604, 2008.
DOI : 10.1016/j.jpeds.2008.06.030

D. Leeuw, E. Borgers, N. Smits, and A. , Pretesting Questionnaires for Children and Adolescents, 2004.
DOI : 10.1002/0471654728.ch20

A. De-rouvray, Integration des préférences émotionnelles et sensorielles dans la conception de produits d'ameublement : proposition d'une méthode d'ingenierie affective: Ecole Nationale Supérieure d'Arts et Métiers, 2006.

D. Wijk, R. Prinz, and J. , MECHANISMS UNDERLYING THE ROLE OF FRICTION IN ORAL TEXTURE, Journal of Texture Studies, vol.34, issue.4, pp.413-440, 2006.
DOI : 10.1016/0001-6918(93)90077-5

A. Deisingh, D. Stone, and M. Thompson, Applications of electronic noses and tongues in food analysis, International Journal of Food Science and Technology, vol.9, issue.6, pp.587-604, 2004.
DOI : 10.1016/S0003-2670(99)00767-9

S. Delestras, M. Roustit, P. Bedouch, M. Minoves, V. Dobremez et al., Comparison between Two Generic Questionnaires to Assess Satisfaction with Medication in Chronic Diseases, PLoS ONE, vol.30, issue.2, p.20, 2013.
DOI : 10.1371/journal.pone.0056247.t006

C. Demuro, S. Lewis, D. Dibenedetti, M. Price, and S. Fehnel, Successful implementation of cognitive interviews in special populations, Expert Review of Pharmacoeconomics & Outcomes Research, vol.87, issue.2, pp.181-188, 2012.
DOI : 10.1002/0471654728.ch25

P. Desmet, P. Hekkert, and J. Jacobs, When a car makes you smile: Development and application of an instrument to measure product emotions, 2000.

S. Diamond and D. Lavallee, Experience With a Pill-Swallowing Enhancement Aid, Clinical Pediatrics, vol.49, issue.4, pp.391-394, 2010.
DOI : 10.1007/s11096-007-9142-y

T. Dietlein, J. Jordan, C. Lüke, A. Schild, S. Dinslage et al., Self-application of single-use eyedrop containers in an elderly population: comparisons with standard eyedrop bottle and with younger patients, Acta Ophthalmologica, vol.74, issue.8, pp.856-865, 2008.
DOI : 10.1038/eye.1998.56

N. Drumond, D. Van-riet-nales, F. Karapinar-carkit, and S. Stegemann, Patients??? appropriateness, acceptability, usability and preferences for pharmaceutical preparations: Results from a literature review on clinical evidence, International Journal of Pharmaceutics, vol.521, issue.1-2, 2017.
DOI : 10.1016/j.ijpharm.2017.02.029

J. Dunbar-jacob, P. Bohachick, M. Mortimer, S. Sereika, and S. Foley, Medication Adherence in Persons With Cardiovascular Disease, The Journal of Cardiovascular Nursing, vol.18, issue.3, p.209, 2003.
DOI : 10.1097/00005082-200307000-00006

C. Easterling and E. Robbins, Dementia and Dysphagia, Geriatric Nursing, vol.29, issue.4, pp.275-85, 2008.
DOI : 10.1016/j.gerinurse.2007.10.015

B. Efron and R. Tibshirani, An introduction to the bootstrap, Boca Raton, 1994.
DOI : 10.1007/978-1-4899-4541-9

H. Eichler, E. Abadie, A. Breckenridge, B. Flamion, L. Gustafsson et al., Bridging the efficacy???effectiveness gap: a regulator's perspective on addressing variability of drug response, Nature Reviews Drug Discovery, vol.9, issue.7, p.495, 2011.
DOI : 10.1038/nrd3169

P. Ekman and W. Friesen, Facial action coding system, 1977.

P. Ekman and E. Rosenberg, What the face reveals: Basic and applied studies of spontaneous expression using the Facial Action Coding System (FACS), 1997.

P. Ekman, Facial expressions: The handbook of cognition and emotion, 1999.

G. El-chaar, G. Mardy, K. Wehlou, and L. Rubin, Randomized, double blind comparison of brand and generic antibiotic suspensions: II. A study of taste and compliance in children. The Pediatric infectious disease journal, pp.18-22, 1996.

M. Essink?bot, M. Stouthard, and G. Bonsel, Generalizability of valuations on health states collected with the EuroQolc-questionnaire, Health Economics, vol.42, issue.3, pp.237-283, 1993.
DOI : 10.1002/hec.4730020307

E. Commission, Better medicines for children from concept to reality. Progress report on the paediatric regulation n°1901, 2006.

A. European-medicine, Reflection paper on the regulatory guidance for the use of health-related quality of life (HRQL) measures in the evaluation of medicinal products, 2005.

A. European-medicine, Reflection paper : formulations of choice for the paediatric population, 2006.

A. European-medicine, Qualification of novel methodologies for drug development: guidance to applicants, 2009.

A. European-medicine, Draft -Guideline on pharmaceutical development of medicines for paediatric use, 2011.

A. European-medicine, 5-year Report to the European Commission -General report on the experience acquired as a result of the application of the paediatric regulation, 2012.

A. European-medicine, Concept paper on the need for a reflection paper on quality aspects of medicines for older people, 2013.

A. European-medicine, Guideline on pharmaceutical development of medicines for paediatric use, 2013.

A. European-medicine, Draft -Reflection paper on the pharmaceutical development of medicines for use in the older population, 2017.

V. Fajolle, C. Dujols, J. Darbord, and D. Rieutord, Oral suspensions of spironolactone, hydrochlorothiazide and captopril: microbiological stability study and clinical use review, J Pharm Clin, vol.24, issue.1, pp.23-32, 2005.

U. Fayyad, Data Mining and Knowledge Discovery: Making Sense Out of Data. IEEE Expert: Intelligent Systems and Their Applications, pp.20-25, 1996.

U. Fayyad, G. Piatetsky-shapiro, and P. Smyth, Knowledge Discovery and Data Mining: Towards a Unifying Framework, 1996.

S. Finger and J. Dixon, A review of research in mechanical engineering design. Part I: Descriptive, prescriptive, and computer-based models of design processes. Research in engineering design, pp.51-67, 1989.

J. Fleiss, J. Cohen, and B. Everitt, Large sample standard errors of kappa and weighted kappa., Psychological Bulletin, vol.72, issue.5, p.323, 1969.
DOI : 10.1037/h0028106

&. Food and . Administration, Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims: draft guidance, Health Qual Life Outcomes, vol.4, p.79, 2006.

&. Food and . Administration, Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims, 2009.

C. Forestell and J. Mennella, Early Determinants of Fruit and Vegetable Acceptance, PEDIATRICS, vol.120, issue.6, pp.1247-54, 2007.
DOI : 10.1542/peds.2007-0858

C. Forestell and J. Mennella, More than just a pretty face. The relationship between infant???s temperament, food acceptance, and mothers??? perceptions of their enjoyment of food, Appetite, vol.58, issue.3, pp.1136-1178, 2012.
DOI : 10.1016/j.appet.2012.03.005

C. Forestell and J. Mennella, The Relationship Between Infant Facial Expressions and Food Acceptance, Current Nutrition Reports, vol.62, issue.S3, pp.141-148, 2017.
DOI : 10.1159/000351538

E. Forgy, Cluster analysis of multivariate data: efficiency versus interpretability of classifications, Biometrics, vol.21, pp.768-777, 1965.

L. Fried, C. Tangen, J. Walston, A. Newman, C. Hirsch et al., Frailty in Older Adults, Biological Sciences and Medical Sciences, vol.56, issue.3, pp.146-57, 2001.
DOI : 10.1016/B978-0-323-03432-6.50096-9

M. Frost, B. Reeve, A. Liepa, J. Stauffer, and R. Hays, What is sufficient evidence for the reliability and validity of patient-reported outcome measures? Value Health, pp.94-105, 2007.

G. Fuchs, S. Mikkelsen, T. Knudsen, and A. Kappelgaard, Ease of use and acceptability of a new pen device for the administration of growth hormone therapy in pediatric patients: An open-label, uncontrolled usability test, Clinical Therapeutics, vol.31, issue.12, pp.312906-312920, 2009.
DOI : 10.1016/j.clinthera.2009.12.014

P. Garvie, S. Lensing, and S. Rai, Efficacy of a Pill-Swallowing Training Intervention to Improve Antiretroviral Medication Adherence in Pediatric Patients With HIV/AIDS, PEDIATRICS, vol.119, issue.4, pp.893-902, 2007.
DOI : 10.1542/peds.2006-1488

S. Gil, Comment étudier les émotions en laboratoire ? Revue électronique de Psychologie Sociale, pp.15-24, 2009.

B. Glaser and A. Strauss, The Discovery of Grounded Theory?strategies for qualitative research, Weiderfield & Nicholson, p.271, 1967.

W. Gooch, A. Philips, R. Rhoades, R. Rosenberg, R. Schaten et al., Comparison of the efficacy, safety and acceptability of cefixime and amoxicillin/clavulanate in acute otitis media. The Pediatric infectious disease journal, pp.21-25, 1997.

Y. Gousty, Le génie industriel. Que sais-je?, 1998.

N. Guffon, Y. Kibleur, W. Copalu, C. Tissen, and J. Breitkreutz, Developing a new formulation of sodium phenylbutyrate. Archives of disease in childhood, pp.2012-302398

M. Guhmann, M. Preis, F. Gerber, N. Pöllinger, J. Breitkreutz et al., Development of oral taste masked diclofenac formulations using a taste sensing system, International Journal of Pharmaceutics, vol.438, issue.1-2, pp.81-90, 2012.
DOI : 10.1016/j.ijpharm.2012.08.047

J. Guinard, Sensory and consumer testing with children, Trends in Food Science & Technology, vol.11, issue.8, pp.273-83, 2001.
DOI : 10.1016/S0924-2244(01)00015-2

H. Gupta, A. Sharma, S. Kumar, and S. Roy, E-tongue: a tool for taste evaluation. Recent patents on drug delivery & formulation, pp.82-91, 2010.

S. Hanning, F. Lopez, I. Wong, T. Ernest, C. Tuleu et al., Patient centric formulations for paediatrics and geriatrics: Similarities and differences, International Journal of Pharmaceutics, vol.512, issue.2, pp.30216-30218, 2016.
DOI : 10.1016/j.ijpharm.2016.03.017

D. Hansen, D. Tulinius, and E. Hansen, Adolescents??? struggles with swallowing tablets: barriers, strategies and learning, Pharmacy World & Science, vol.60, issue.1, pp.65-74, 2008.
DOI : 10.3109/02813438709018102

A. Hasamnis, S. Patil, A. Kumar, K. Thu, and B. Mohanty, Preferences of medical students regarding physical characteristics of oral solid dosage formulations in Malaysia, Journal of Pharmacology and Pharmacotherapeutics, vol.2, issue.2, pp.119-139, 2011.
DOI : 10.4103/0976-500X.81909

R. Hays, S. Farivar, and H. Liu, Approaches and Recommendations for Estimating Minimally Important Differences for Health-Related Quality of Life Measures, COPD: Journal of Chronic Obstructive Pulmonary Disease, vol.7, issue.1, pp.63-70, 2005.
DOI : 10.1111/j.0006-341X.2000.01197.x

C. Hennig, Cluster-wise assessment of cluster stability, Computational Statistics & Data Analysis, vol.52, issue.1, pp.258-71, 2007.
DOI : 10.1016/j.csda.2006.11.025

D. Herd and B. Salehi, Palatability of two forms of paracetamol (acetaminophen) suspension: a randomised trial Paediatric and Perinatal Drug Therapy, pp.189-93, 2006.

H. Thi and T. , Développement et evaluation de médicaments a usage pediatrique : masquage de goût du principe actif et fabrication de minigranules à désintégration rapide Lille 2, 2012.

J. Hoppe, Rational Prescribing of Antibacterials in Ambulatory Children, PharmacoEconomics, vol.10, issue.6, pp.552-74, 1996.
DOI : 10.2165/00019053-199610060-00004

K. Hoppu, G. Anabwani, F. Garcia-bournissen, M. Gazarian, G. Kearns et al., The status of paediatric medicines initiatives around the world?what has happened and what has not? European journal of clinical pharmacology, pp.1-10, 2012.

L. Hubert and P. Arabie, Comparing partitions, Journal of Classification, vol.78, issue.1, pp.193-218, 1985.
DOI : 10.1007/978-3-642-69024-2_27

F. Husson, J. Josse, and J. Pages, Principal component methods-hierarchical clustering-partitional clustering: why would we need to choose for visualizing data, Applied Mathematics Department, 2010.

S. Hyde, S. Gansky, M. Gonzalez-vargas, S. Husting, N. Cheng et al., Developing an Acceptability Assessment of Preventive Dental Treatments, Journal of Public Health Dentistry, vol.16, issue.141, pp.18-23, 2009.
DOI : 10.1016/S0033-3549(04)50253-4

I. Ibrahim, M. Izham, and M. Haddad, Preferences of color, size, shape, and taste of oral solid dosage forms, Pharmacologyonline, vol.2, pp.754-62, 2010.

L. Immohr, A. Dischinger, P. Kühl, H. Kletzl, S. Sturm et al., Early pediatric formulation development with new chemical entities: Opportunities of e-tongue besides human taste assessment, International Journal of Pharmaceutics, vol.530, issue.1-2, 2017.
DOI : 10.1016/j.ijpharm.2017.07.069

. Iso, Analyse sensorielle -Méthodologie -Directives générales pour l'établissement d'un profil sensoriel, 2003.

V. Ivanovska, C. Rademaker, L. Van-dijk, and A. Mantel-teeuwisse, Pediatric Drug Formulations: A Review of Challenges and Progress, PEDIATRICS, vol.134, issue.2, pp.361-72, 2014.
DOI : 10.1542/peds.2013-3225

C. Izard, F. Dougherty, B. Bloxom, and N. Kotsch, The Differential Emotions Scale: a Method of Meusuring the Subjecfive Experience of Discrete Emotions, 1974.

P. Jaccard, Distribution de la flore alpine dans le bassin des Dranses et dans quelques régions voisines, Bull Soc Vaud Sci Nat, vol.37, pp.241-72, 1901.

L. Jacobsen, A. Patel, M. Fox, S. Miller, K. Bradford et al., A pilot study of the Pediatric Oral Medications Screener (POMS) Hospital pediatrics, pp.586-90, 2015.

T. Jahnsen and P. Thorn, An acceptability study of two pivampicillin mixtures in children in general practice. Scandinavian journal of primary health care, pp.241-244, 1987.

S. Jensen and S. U. , Mining medical data for predictive and sequential patterns: PKDD, Proceedings of the 5th European Conference on Principles and Practice of Knowledge Discovery in Databases, 2001.

D. Johnson, A. Roach, A. Carlsson, A. Karlsson, and D. Behr, Stability of Esomeprazole Capsule Contents After In Vitro Suspension in Common Soft Foods and Beverages, Pharmacotherapy, vol.92, issue.6, pp.731-735, 2003.
DOI : 10.1111/j.1572-0241.2001.03600.x

D. Jones and N. Kronemer, Parents' Response to a Drug Study, Clinical Pediatrics, vol.63, issue.3, pp.137-177, 1965.
DOI : 10.1177/000992286500400304

. Jordan and . Pw, Designing Pleasurable Products, 2000.
DOI : 10.4324/9780203305683

J. Josse, J. Pages, and F. Husson, Testing the significance of the RV coefficient, Computational Statistics & Data Analysis, vol.53, issue.1, pp.82-91, 2008.
DOI : 10.1016/j.csda.2008.06.012

URL : https://hal.archives-ouvertes.fr/hal-00360535

J. Josse and F. Husson, missMDA a package to handle missing values in principal component methods, Journal of Statistical Software, 2015.

D. Kaufman, J. Kelly, L. Rosenberg, T. Anderson, and A. Mitchell, Recent Patterns of Medication Use in the Ambulatory Adult Population of the United States, JAMA, vol.287, issue.3, pp.337-381, 2002.
DOI : 10.1001/jama.287.3.337

P. Kayumba, N. Huyghebaert, C. Cordella, J. Ntawukuliryayo, C. Vervaet et al., Quinine sulphate pellets for flexible pediatric drug dosing: Formulation development and evaluation of taste-masking efficiency using the electronic tongue, European Journal of Pharmaceutics and Biopharmaceutics, vol.66, issue.3, pp.460-465, 2007.
DOI : 10.1016/j.ejpb.2006.11.018

G. Kearns, S. Abdel-rahman, S. Alander, D. Blowey, J. Leeder et al., Developmental Pharmacology ??? Drug Disposition, Action, and Therapy in Infants and Children, New England Journal of Medicine, vol.349, issue.12, pp.1157-67, 2003.
DOI : 10.1056/NEJMra035092

A. Keating, J. Soto, C. Tuleu, C. Forbes, M. Zhao et al., Solid state characterisation and taste masking efficiency evaluation of polymer based extrudates of isoniazid for paediatric administration, International Journal of Pharmaceutics, vol.536, issue.2, 2017.
DOI : 10.1016/j.ijpharm.2017.07.008

J. Kelly and D. Wright, Administering medication to adult patients with dysphagia, Nursing Standard, vol.23, issue.29, pp.62-70, 2009.
DOI : 10.7748/ns2009.

S. Keram and M. Williams, Quantifying the Ease or Difficulty Older Persons Experience in Opening Medication Containers, Journal of the American Geriatrics Society, vol.12, issue.3, pp.198-201, 1988.
DOI : 10.3109/15563657809150487

C. Kerr, A. Nixon, and D. Wild, Assessing and demonstrating data saturation in qualitative inquiry supporting patient-reported outcomes research, Expert Review of Pharmacoeconomics & Outcomes Research, vol.19, issue.3, pp.269-81, 2010.
DOI : 10.1016/j.seizure.2009.10.007

A. Khan, R. Carmona, and M. Traube, Dysphagia in the Elderly, Clinics in Geriatric Medicine, vol.30, issue.1, pp.43-53, 2014.
DOI : 10.1016/j.cger.2013.10.009

M. Khan, J. Choi, H. Shin, and M. Kim, Predicting breast cancer survivability using fuzzy decision trees for personalized healthcare, 30th Annual International Conference of the IEEE, 2008.

S. Kline and N. Rosenberg, An overview of innovation. The positive sum strategy: Harnessing technology for economic growth, p.640, 1986.

V. Klingmann, N. Spomer, C. Lerch, I. Stoltenberg, C. Fromke et al., Favorable Acceptance of Mini-Tablets Compared with Syrup: A??Randomized Controlled Trial in Infants and Preschool Children, The Journal of Pediatrics, vol.163, issue.6
DOI : 10.1016/j.jpeds.2013.07.014

V. Klingmann, A. Seitz, T. Meissner, J. Breitkreutz, A. Moeltner et al., Acceptability of Uncoated Mini-Tablets in Neonates???A Randomized Controlled Trial, The Journal of Pediatrics, vol.167, issue.4, pp.732-737, 2015.
DOI : 10.1016/j.jpeds.2015.07.010

W. Klösgen and J. ?ytkow, Knowledge discovery in databases terminology Advances in knowledge discovery and data mining, 1996.

A. Kluk, M. Sznitowska, A. Brandt, K. Sznurkowska, K. Plata-nazar et al., Can preschool-aged children swallow several minitablets at a time? Results from a clinical pilot study, International Journal of Pharmaceutics, vol.485, issue.1-2, pp.196-205, 2015.
DOI : 10.1016/j.ijpharm.2015.02.068

H. Kokki, E. Nikanne, and R. Ahonen, The feasibility of pain treatment at home after adenoidectomy with ketoprofen tablets in small children, Pediatric Anesthesia, vol.86, issue.5, pp.531-536, 2000.
DOI : 10.1213/00000539-199803000-00008

P. Kozarewicz, Regulatory perspectives on acceptability testing of dosage forms in children, International Journal of Pharmaceutics, vol.469, issue.2, pp.245-253, 2014.
DOI : 10.1016/j.ijpharm.2014.03.057

D. Kraus, L. Stohlmeyer, and P. Hannon, Infant acceptance and effectiveness of a new oral liquid medication delivery system American journal of health-system pharmacy, pp.1094-101, 1999.

D. Kraus, L. Stohlmeyer, P. Hannon, and S. Freels, Effectiveness and Infant Acceptance of the Rx Medibottle versus the Oral Syringe, Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy, vol.13, issue.2, pp.416-439, 2001.
DOI : 10.1542/peds.100.3.330

A. Kreeftmeijer-vegter, M. De-meijer, K. Wegman, and C. Van-veldhuizen, Development and evaluation of age-appropriate film-coated tablets of levamisole for paediatric use (2?18 years) Expert opinion on drug delivery, pp.293-300, 2013.

S. Kromm, J. Bethell, F. Kraglund, S. Edwards, A. Laporte et al., Characteristics and quality of pediatric cost-utility analyses, Quality of Life Research, vol.20, issue.3, pp.1315-1340, 2012.
DOI : 10.1177/1049732309358328

L. Kurgan and P. Musilek, A survey of Knowledge Discovery and Data Mining process models, The Knowledge Engineering Review, vol.21, issue.01, pp.1-24, 2006.
DOI : 10.1017/S0269888906000737

J. Landis and G. Koch, The Measurement of Observer Agreement for Categorical Data, Biometrics, vol.33, issue.1, pp.159-74
DOI : 10.2307/2529310

K. Lasch, P. Marquis, M. Vigneux, L. Abetz, B. Arnould et al., PRO development: rigorous qualitative research as the crucial foundation, Quality of Life Research, vol.23, issue.3, pp.1087-96, 2010.
DOI : 10.4135/9781412985659

J. Lawrence, D. Alcock, P. Mcgrath, J. Kay, S. Macmurray et al., The development of a tool to assess neonatal pain, Journal of Pain and Symptom Management, vol.6, issue.3, pp.59-66, 1993.
DOI : 10.1016/0885-3924(91)91127-U

M. Lawton and E. Brody, ASSESSMENT OF OLDER PEOPLE, Nursing Research, vol.19, issue.3, p.278, 1970.
DOI : 10.1097/00006199-197005000-00029

S. Le, J. Josse, and F. Husson, FactoMineR: an R package for multivariate analysis, Journal of Statistical Software, vol.25, issue.1, pp.1-18, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00359835

J. Lévy, J. Samson, C. Garnier, E. Lasserre, and P. Parvaresh, Critères pharmacologiques et sensoriels dans l'évaluation des médicaments parmi les étudiants universitaires québécois et français : une étude exploratoire. Revue Internationale sur le Médicament, 2012.

S. Lindgren and L. Janzon, Prevalence of swallowing complaints and clinical findings among 50???79-year-old men and women in an urban population, Dysphagia, vol.3, issue.4, pp.187-92, 1991.
DOI : 10.1007/BF02493524

C. Lippert, S. Gbenado, C. Qiu, B. Lavin, and S. Kovacs, The Bioequivalence of Telithromycin Administered Orally as Crushed Tablets Versus Tablets Swallowed Whole, The Journal of Clinical Pharmacology, vol.9, issue.Suppl A, pp.1025-1056, 2005.
DOI : 10.1046/j.1469-0691.2003.00678.x

R. Lisberg, C. Higham, and J. M. , PROBLEMS FOR RHEUMATIC PATIENTS IN OPENING DISPENSED DRUG CONTAINERS, Rheumatology, vol.22, issue.2, pp.95-103, 1983.
DOI : 10.1093/rheumatology/22.2.95

F. Liu, S. Ranmal, H. Batchelor, M. Orlu-gul, T. Ernest et al., Patient-Centered Pharmaceutical Design to Improve Acceptability of Medicines: Similarities and Differences in Paediatric and Geriatric Populations, Drugs, vol.370, issue.106, pp.1871-89, 2014.
DOI : 10.1016/j.ijpharm.2008.11.005

F. Liu, A. Ghaffur, J. Bains, and S. Hamdy, Acceptability of oral solid medicines in older adults with and without dysphagia: A nested pilot validation questionnaire based observational study, International Journal of Pharmaceutics, vol.512, issue.2, pp.30197-30198, 2016.
DOI : 10.1016/j.ijpharm.2016.03.007

F. Lopez, A. Bowles, M. Gul, D. Clapham, T. Ernest et al., Effect of formulation variables on oral grittiness and preferences of multiparticulate formulations in adult volunteers, European Journal of Pharmaceutical Sciences, vol.92, pp.156-62, 2016.
DOI : 10.1016/j.ejps.2016.07.006

J. Lorenz, J. Reo, O. Hendl, J. Worthington, and V. Petrossian, Evaluation of a taste sensor instrument (electronic tongue) for use in formulation development, International Journal of Pharmaceutics, vol.367, issue.1-2, pp.65-72, 2009.
DOI : 10.1016/j.ijpharm.2008.09.042

M. Lucas-bouwman, R. Roorda, F. Jansman, and P. Brand, Crushed prednisolone tablets or oral solution for acute asthma? Archives of disease in childhood, pp.347-355, 2001.

R. Maher, J. Hanlon, and E. Hajjar, Clinical consequences of polypharmacy in elderly, Expert Opinion on Drug Safety, vol.5, issue.1, pp.57-65, 2014.
DOI : 10.2165/00003495-200969040-00001

O. Maimon and L. Rokach, Data Mining and Knowledge Discovery Handbook, 2010.

S. Manificat and A. Dazord, Evaluation of the Child's Quality of Life: Validation of a Questionnaire and First Results) [In French] Évaluation de la qualité de vie de l'enfant: validation d'un questionnaire, premiers résultats. Neuropsychiatrie de l, Enfance et de l'Adolescence, vol.45, issue.3, pp.106-120, 1997.

S. Manificat, A. Dazord, J. Langue, G. Danjou, P. Bauche et al., Evaluation de la qualit?? de vie du nourrisson et du tr??s jeune enfant: Validation d'un questionnaire. ??tude multicentrique europ??enne, Archives de P??diatrie, vol.7, issue.6, pp.605-619, 2000.
DOI : 10.1016/S0929-693X(00)80127-X

F. Mantelet, Prise en compte de la perception émotionnelle du consommateur dans le processus de conception de produits, 2006.

C. Marant, J. Longin, R. Gauchoux, B. Arnould, C. Spizak et al., Long-Term Treatment Acceptance, The Patient: Patient-Centered Outcomes Research, vol.36, issue.3, pp.239-288, 2012.
DOI : 10.1097/00126334-200407010-00007

DOI : 10.1016/S1098-3015(10)66877-5

J. Martinez, F. Bartoli, E. Recaldini, L. Lavanchy, and M. Bianchetti, A Taste Comparison of Two Different Liquid Colecalciferol (Vitamin D3) Preparations in Healthy Newborns and Infants, Clinical Drug Investigation, vol.10, issue.11, pp.663-669, 2006.
DOI : 10.1001/archpedi.155.2.173

J. Martir, T. Flanagan, J. Mann, and N. Fotaki, Recommended strategies for the oral administration of paediatric medicines with food and drinks in the context of their biopharmaceutical properties: a review, Journal of Pharmacy and Pharmacology, vol.4, issue.Pt 1, 2016.
DOI : 10.1590/S1984-82502013000400026

J. Mason, M. Pirmohamed, and T. Nunn, Off-label and unlicensed medicine use and adverse drug reactions in children: a narrative review of the literature, European Journal of Clinical Pharmacology, vol.58, issue.1, pp.21-29, 2012.
DOI : 10.1007/s00228-002-0554-2

D. Matsui, Assessing the palatability of medications in children. Paediatric and Perinatal Drug Therapy, pp.55-60, 2007.

D. Matsui, Current Issues in Pediatric Medication Adherence, Pediatric Drugs, vol.41, issue.7557, pp.283-291, 2007.
DOI : 10.2165/00128072-200204050-00005

L. Matza, D. Patrick, A. Riley, J. Alexander, L. Rajmil et al., Pediatric Patient-Reported Outcome Instruments for Research to Support Medical Product Labeling: Report of the ISPOR PRO Good Research Practices for the Assessment of Children and Adolescents Task Force, Value in Health, vol.16, issue.4, pp.461-79, 2013.
DOI : 10.1016/j.jval.2013.04.004

J. Mayer and Y. Gaschke, The experience and meta-experience of mood., Journal of Personality and Social Psychology, vol.55, issue.1, p.102, 1988.
DOI : 10.1037/0022-3514.55.1.102

A. Mehrabian and J. Russell, An approach to environmental psychology: the, 1974.

J. Mekmullica and C. Pancharoen, Acceptability of oral typhoid vaccine in Thai children, Southeast Asian J Trop Med Public Health, vol.34, issue.2, pp.334-340, 2003.

E. Meltzer, M. Welch, and N. Ostrom, Pill Swallowing Ability and Training in Children 6 to 11 Years of Age, Clinical Pediatrics, vol.94, issue.8, pp.725-758, 2006.
DOI : 10.1016/S0140-6736(97)07302-9

J. Mennella and G. Beauchamp, Optimizing oral medications for children, Clinical Therapeutics, vol.30, issue.11, pp.2120-2152, 2008.
DOI : 10.1016/j.clinthera.2008.11.018

J. Mennella, A. Spector, D. Reed, and S. Coldwell, The Bad Taste of Medicines: Overview of Basic Research on Bitter Taste, Clinical Therapeutics, vol.35, issue.8, pp.1225-1271, 2013.
DOI : 10.1016/j.clinthera.2013.06.007

J. Mennella and N. Bobowski, The sweetness and bitterness of childhood: Insights from basic research on taste preferences, Physiology & Behavior, vol.152, issue.15, p.15, 2015.
DOI : 10.1016/j.physbeh.2015.05.015

D. Mentzer, Progress review of the European Paediatric Regulatory Framework after six years of implementation, International Journal of Pharmaceutics, vol.469, issue.2, pp.240-243, 2014.
DOI : 10.1016/j.ijpharm.2014.03.019

C. Messina-gourlot, N. Richard, M. Courné, M. Mallaret, and A. Castot, Guideline on the formulation of psychoactive drug products to minimize misuse, abuse and diversion. Fundamental and Clinical Pharmacology, pp.98-107, 2009.

J. Mestre-ferrandiz, J. Sussex, and A. Towse, The R&D cost of a new medicine, 2012.

A. Mohamed, V. Kilambi, M. Luo, R. Iyer, and J. Li-mcleod, Patient and parent preferences for immunoglobulin treatments: a conjoint analysis, Journal of Medical Economics, vol.15, issue.6, pp.1183-91, 2012.
DOI : 10.3111/13696998.2012.716804

N. Moniot-ville, M. Chelly, L. Consten, and M. Rosenbaum, The Acceptability, Efficacy and Safety of a New Paediatric Oral Suspension of Roxithromycin in Respiratory Tract Infections, Journal of International Medical Research, vol.147, issue.3, pp.144-51, 1998.
DOI : 10.1002/j.1552-4604.1989.tb03412.x

D. Morgan, Focus groups as qualitative research: Sage publications, 1996.
DOI : 10.4135/9781412984287

L. Mühlfeld, P. Langguth, H. Häusler, and H. Hagels, Influence of blister package design on usability among older adults, International Journal of Clinical Pharmacy, vol.288, issue.4, pp.553-60, 2012.
DOI : 10.1136/bmj.288.6418.699

H. Mulla, H. Buck, L. Price, A. Parry, G. Bell et al., ???Acceptability??? of a new oral suspension formulation of mercaptopurine in children with acute lymphoblastic leukaemia, Journal of Oncology Pharmacy Practice, vol.85, issue.3, pp.387-95, 2016.
DOI : 10.1016/j.ijpharm.2014.04.069

M. Munster, A. Mohamed-ahmed, L. Immohr, C. Schoch, C. Schmidt et al., Comparative in vitro and in vivo taste assessment of liquid praziquantel formulations, International Journal of Pharmaceutics, vol.529, issue.1-2, pp.310-318, 2017.
DOI : 10.1016/j.ijpharm.2017.06.084

M. Nahata, Lack of pediatric drug formulations, Pediatrics, vol.104, pp.607-616, 1999.

D. Nasrin, C. Larson, S. Sultana, and T. Khan, Acceptability of and adherence to dispersible zinc tablet in the treatment of acute childhood diarrhoea, Journal of Health Population and Nutrition, pp.215-236, 2005.

J. Nguyen, M. Fouts, S. Kotabe, and E. Lo, Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. The American journal of geriatric pharmacotherapy, pp.36-41, 2006.

T. Nikolaus, W. Kruse, M. Bach, N. Specht-leible, P. Oster et al., Elderly patients' problems with medication, European Journal of Clinical Pharmacology, vol.37, issue.4, pp.255-264, 1996.
DOI : 10.1111/j.1532-5415.1989.tb01252.x

H. Nilsson, O. Ekberg, R. Olsson, and B. Hindfelt, Quantitative aspects of swallowing in an elderly nondysphagic population, Dysphagia, vol.10, issue.3, pp.180-184, 1996.
DOI : 10.1016/0016-5085(90)91078-K

K. Notenboom, E. Beers, D. Riet?nales, T. Egberts, H. Leufkens et al., Practical Problems with Medication Use that Older People Experience: A Qualitative Study, Journal of the American Geriatrics Society, vol.30, issue.Suppl A, pp.2339-2383, 2014.
DOI : 10.1177/8755122513512111

T. Nunn and J. Williams, Formulation of medicines for children, British Journal of Clinical Pharmacology, vol.179, issue.4, pp.674-680, 2005.
DOI : 10.1111/j.1365-2125.2005.02410.x

S. Ohannessian, zero" option in conjoint analysis: a new specication of the indecision and the refusal. Application to the Video on Demand market.: Conservatoire national des arts et metiers, 2008.

V. Olsen, I. Gustavsen, J. Bramness, I. Hasvold, R. Karinen et al., The concentrations, appearance and taste of nine sedating drugs dissolved in four different beverages, Forensic Science International, vol.151, issue.2-3, pp.2-3171, 2005.
DOI : 10.1016/j.forsciint.2005.01.017

E. Organisation, . Cooporation, and . Development, Oslo Manual-Guidelines for Collecting and Interpreting Innovation Data: Proposed Guidelines for Collecting and Interpreting Innovation Data: Organisation for Economic Cooporation and Development, 2005.

A. Overgaard, J. Hojsted, R. Hansen, J. Moller-sonnergaard, and L. Christrup, Patients' evaluation of shape, size and colour of solid dosage forms, Pharmacy World and Science, vol.23, issue.5, pp.185-193, 2001.
DOI : 10.1023/A:1012050931018

J. Pagès, Multiple Factor Analysis by Example Using R, Boca Raton, 2016.
DOI : 10.1201/b17700

G. Pahl, W. Beitz, J. Feldhusen, and K. Grote, Engineering Design: A Systematic Approach, 2007.

C. Pandolfini and M. Bonati, A literature review on off-label drug use in children, European Journal of Pediatrics, vol.8, issue.9, pp.552-560, 2005.
DOI : 10.1136/bmj.316.7128.343

P. Européen, Directive 2001.83.CE. Code communautaire relatif aux médicaments à usage humain, Journal officiel des Communautés européennes, 2001.

P. Européen and . Reglement, CE. Médicaments à usage pédiatrique Journal officiel de l'Union européenne, 1901.

D. Patrick, L. Burke, C. Gwaltney, N. Leidy, M. Martin et al., Content Validity???Establishing and Reporting the Evidence in Newly Developed Patient-Reported Outcomes (PRO) Instruments for Medical Product Evaluation: ISPOR PRO Good Research Practices Task Force Report: Part 1???Eliciting Concepts for a New PRO Instrument, Value in Health, vol.14, issue.8, pp.967-77, 2011.
DOI : 10.1016/j.jval.2011.06.014

D. Patrick, L. Burke, C. Gwaltney, N. Leidy, M. Martin et al., Content Validity???Establishing and Reporting the Evidence in Newly Developed Patient-Reported Outcomes (PRO) Instruments for Medical Product Evaluation: ISPOR PRO Good Research Practices Task Force Report: Part 2???Assessing Respondent Understanding, Value in Health, vol.14, issue.8, pp.978-88, 2011.
DOI : 10.1016/j.jval.2011.06.013

A. Pense-lheritier, Intégration sensorielle et sociétale dans la conception produit. Levier d'innovation dans le secteur des bioindustries, Cergey, pp.2-2013

A. Pense-lheritier, T. Vallet, A. A. Courne, M. Lavarde, and M. , Descriptive Analysis of A Complex Product Space: Drug?Beverage Mixtures. journal of sensory studies, pp.101-114, 2016.

I. Perquy, E. Belissa, T. Vallet, F. Ruiz, C. A. Chedhomme et al., Acceptabilité des anticoagulants chez les personnes de plus de 65 ans, 37ème Journées Annuelles de la Société Française de Gériatrie et Gérontologie, 2017.

A. Phillips, C. Kozma, and J. Locklear, Using a panel survey to identify predictors of disease-modifying drug adherence in patients with multiple sclerosis. ISPOR 17th Annual European Congress

G. Piateski and W. Frawley, Knowledge discovery in databases, 1991.

É. Poirson, Prise en compte des perceptions de l'utilisateur en conception de produit: application aux instruments de musique de type cuivre2005

R. Popper and J. Kroll, conducting sensory research with children. journal of sensory studies, pp.75-87, 2005.

C. Poulos, A. Hauber, J. Gonzalez, and A. Turpcu, Patients' Willingness to Trade Off Between the Duration and Frequency of Rheumatoid Arthritis Treatments, Arthritis Care & Research, vol.28, issue.7, pp.1008-1023, 2014.
DOI : 10.1017/CBO9780511610356

E. Qannari, P. Courcoux, and F. P. , Significance test of the adjusted Rand index. Application to the free sorting task, Food Quality and Preference, vol.32, pp.93-100, 2014.
DOI : 10.1016/j.foodqual.2013.05.005

Z. Rajaei-dehkordi and G. Mcpherson, The effects of multiple medication in the elderly, Nursing times, vol.93, issue.27, pp.56-64, 1996.

A. Ramgoolam and R. Steele, Formulations of Antibiotics for Children in Primary Care, Pediatric Drugs, vol.17, issue.10, pp.323-356, 2002.
DOI : 10.2165/00128072-200204050-00005

W. Rand, Objective Criteria for the Evaluation of Clustering Methods, Journal of the American Statistical Association, vol.15, issue.336, pp.846-50, 1971.
DOI : 10.1080/01621459.1963.10500845

R. Johnson, F. Lancsar, E. Marshall, D. Kilambi, V. Muhlbacher et al., Constructing Experimental Designs for Discrete-Choice Experiments: Report of the ISPOR Conjoint Analysis Experimental Design Good Research Practices Task Force, Value in Health, vol.16, issue.1, pp.3-13, 2013.
DOI : 10.1016/j.jval.2012.08.2223

V. Reiner, N. Giarratana, N. Monti, A. Breitenbach, and P. Klaffenbach, Rapidfilm??: An innovative pharmaceutical form designed to improve patient compliance, International Journal of Pharmaceutics, vol.393, issue.1-2, pp.55-60, 2010.
DOI : 10.1016/j.ijpharm.2010.03.055

J. Rejas, M. Ruiz, A. Pardo, and J. Soto, Minimally important difference of the Treatment Satisfaction with Medicines Questionnaire (SATMED-Q), BMC Med Res Methodol, vol.11, issue.142, pp.1471-2288, 2011.

J. Rejas, M. Ruiz, A. Pardo, and J. Soto, Detecting changes in patient treatment satisfaction with medicines: the SATMED-Q. Value Health, pp.88-96, 2013.

D. Revicki, D. Cella, R. Hays, J. Sloan, W. Lenderking et al., Responsiveness and minimal important differences for patient reported outcomes. Health and quality of life outcomes, p.70, 2006.

D. Revicki, R. Hays, D. Cella, and J. Sloan, Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes, Journal of Clinical Epidemiology, vol.61, issue.2, pp.102-111, 2008.
DOI : 10.1016/j.jclinepi.2007.03.012

C. Riera, H. Vogel, S. Simon, and J. Le-coutre, Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol.293, issue.2, pp.626-660, 2007.
DOI : 10.1038/22761

P. Robert and Y. Escoufier, A Unifying Tool for Linear Multivariate Statistical Methods: The RV- Coefficient, Applied Statistics, vol.25, issue.3, pp.257-65, 1976.
DOI : 10.2307/2347233

L. Rokach and O. Maimon, Data Mining with Decision Trees: Theory and Applications, 2014.

D. Rosenstein and H. Oster, Differential facial responses to four basic tastes in newborns. Child development, pp.1555-68, 1988.

F. Ruiz, T. Vallet, A. Pense-lheritier, and A. Aoussat, Standardized method to assess medicines??? acceptability: focus on paediatric population, Journal of Pharmacy and Pharmacology, vol.6, issue.2, p.12547, 2016.
DOI : 10.1007/s00431-012-1872-8

M. Ruiz, A. Pardo, J. Rejas, J. Soto, F. Villasante et al., Development and Validation of the ???Treatment Satisfaction with Medicines Questionnaire??? (SATMED-Q)??, Value in Health, vol.11, issue.5, pp.913-939, 2008.
DOI : 10.1111/j.1524-4733.2008.00323.x

J. Ruscin and T. Semla, Assessment of Medication Management Skills in Older Outpatients, Annals of Pharmacotherapy, vol.23, issue.10, pp.1083-1091, 1996.
DOI : 10.1111/j.1532-5415.1995.tb05808.x

J. Russell and A. Mehrabian, Evidence for a three-factor theory of emotions, Journal of Research in Personality, vol.11, issue.3, pp.273-94, 1977.
DOI : 10.1016/0092-6566(77)90037-X

X. Sáez-llorens, R. Yogev, A. Arguedas, A. Rodriguez, M. Spigarelli et al., Pharmacokinetics and Safety of Famciclovir in Children with Herpes Simplex or Varicella-Zoster Virus Infection, Antimicrobial Agents and Chemotherapy, vol.53, issue.5, pp.1912-1932, 2009.
DOI : 10.1128/AAC.01054-08

S. Salunke and C. Tuleu, Formulating better medicines for children???Still too far to walk, International Journal of Pharmaceutics, vol.511, issue.2, pp.1124-1130, 2016.
DOI : 10.1016/j.ijpharm.2016.06.114

S. Salunke and C. Tuleu, Formulating better medicines for children???Collaborate to innovate, International Journal of Pharmaceutics, vol.536, issue.2, 2017.
DOI : 10.1016/j.ijpharm.2017.08.009

K. Scherer, The nature and function of emotion, Social Science Information, vol.21, issue.4-5, p.317, 1984.
DOI : 10.1177/053901882021004001

J. Schiele, H. Penner, H. Schneider, R. Quinzler, G. Reich et al., Swallowing Tablets and Capsules Increases the Risk of Penetration and Aspiration in Patients with Stroke-Induced Dysphagia, Dysphagia, vol.24, issue.5, pp.571-82, 2015.
DOI : 10.1007/s00455-008-9183-y

T. Shah, A. Tse, H. Gill, I. Wong, A. Sutcliffe et al., Administration of melatonin mixed with soft food and liquids for children with neurodevelopmental difficulties, Developmental Medicine & Child Neurology, vol.29, issue.11, pp.845-854, 2008.
DOI : 10.1177/088307380101600808

D. Shalvi, A data clustering and visualization methodology for epidemiological pathology discoveries, Medical Data Mining and Knowledge Discovery, pp.120-51, 2001.

C. Shearer, The CRISP-DM model: the new blueprint for data mining, Journal of data warehousing, vol.5, issue.4, pp.13-22, 2000.

R. Shikiar and A. Rentz, Satisfaction with Medication: An Overview of Conceptual, Methodologic, and Regulatory Issues, Value in Health, vol.7, issue.2, pp.204-219, 2004.
DOI : 10.1111/j.1524-4733.2004.72252.x

M. Siddiqui, G. Garg, and P. Sharma, A short review on " A novel approach in oral fast dissolving drug delivery system and their patents, Advances in Biological Research, vol.5, issue.6, pp.291-303, 2011.

K. Simojoki, P. Lillsunde, N. Lintzeris, and H. Alho, Bioavailability of buprenorphine from crushed and whole buprenorphine (subutex) tablets. European addiction research, pp.85-90, 2010.

A. Simon, The Science of the Artificial/Herbert, Cambridge (Mass, 1969.

J. Sjövall, A. Fogh, B. Huitfeldt, G. Karlsson, and O. Nylen, Methods for evaluating the taste of paediatric formulations in children: A comparison between the facial hedonic method and the patients' own spontaneous verbal judgement, European Journal of Pediatrics, vol.34, issue.4, pp.243-250, 1984.
DOI : 10.1007/BF00572770

C. Skwierczynski and S. Conroy, How long does it take to administer oral medicines to children? Paediatric and Perinatal Drug Therapy, pp.145-154, 2008.

J. Soto, Y. Sheng, J. Standing, O. Gul, M. Tuleu et al., Development of a model for robust and exploratory analysis of the rodent brief-access taste aversion data, European Journal of Pharmaceutics and Biopharmaceutics, vol.91, pp.47-51, 2015.
DOI : 10.1016/j.ejpb.2015.01.016

N. Spomer, V. Klingmann, I. Stoltenberg, C. Lerch, T. Meissner et al., Acceptance of uncoated mini-tablets in young children: results from a prospective exploratory cross-over study, Archives of Disease in Childhood, vol.97, issue.3, pp.283-289, 2012.
DOI : 10.1136/archdischild-2011-300958

L. Squires, D. Lombardi, P. Sjostedt, and C. Thompson, A Systematic Literature Review on the Assessment of Palatability and Swallowability in the Development of Oral Dosage Forms for Pediatric Patients. Therapeutic Innovation and Regulatory Science, pp.533-574, 2013.

L. Stafford, M. Hope, E. Janney, and J. Ailakis, Comparison of Paediatric Steroid Mixtures, The Australian Journal of Hospital Pharmacy, vol.23, issue.4, pp.246-255, 1998.
DOI : 10.1007/BF01742988

J. Standing, Z. Khaki, and I. Wong, Poor Formulation Information in Published Pediatric Drug Trials, PEDIATRICS, vol.116, issue.4, pp.559-62, 2005.
DOI : 10.1542/peds.2005-0327

J. Standing and C. Tuleu, Paediatric formulations???Getting to the heart of the problem, International Journal of Pharmaceutics, vol.300, issue.1-2, pp.56-66, 2005.
DOI : 10.1016/j.ijpharm.2005.05.006

C. Steele, C. Greenwood, I. Ens, C. Robertson, and R. Seidman-carlson, Mealtime Difficulties in a Home for the Aged: Not Just Dysphagia, Dysphagia, vol.12, issue.1, pp.43-50, 1997.
DOI : 10.1007/PL00009517

G. Steffensen, A. Pachai, and S. Pedersen, Peroral drug administration to children--are there any problems? Ugeskrift for laeger, pp.2249-52, 1998.

S. Stegemann, M. Gosch, and J. Breitkreutz, Swallowing dysfunction and dysphagia is an unrecognized challenge for oral drug therapy, International Journal of Pharmaceutics, vol.430, issue.1-2, pp.197-206, 2012.
DOI : 10.1016/j.ijpharm.2012.04.022

S. Stegemann, R. Ternik, G. Onder, M. Khan, and D. Van-riet-nales, Defining Patient Centric Pharmaceutical Drug Product Design, The AAPS Journal, vol.18, issue.5, pp.1047-55, 2016.
DOI : 10.1208/s12248-016-9938-6

J. Steiner, Human facial expressions in response to taste and smell stimulation Advances in child development and behavior, pp.257-95, 1979.

I. Stoltenberg and J. Breitkreutz, Orally disintegrating mini-tablets (ODMTs) ??? A novel solid oral dosage form for paediatric use, European Journal of Pharmaceutics and Biopharmaceutics, vol.78, issue.3, pp.462-471, 2011.
DOI : 10.1016/j.ejpb.2011.02.005

H. Stone, J. Sidel, S. Oliver, A. Woolsey, and R. Singleton, Sensory evaluation by quantitative descriptive analysis. Descriptive Sensory Analysis in Practice, pp.23-34, 2008.

I. Strachan and M. Greener, Medication-related swallowing difficulties may be more common than we realise, Pharm Pract, vol.15, issue.10, pp.411-415, 2005.

N. Suh, Axiomatic design: Advances and applications (the oxford series on advanced manufacturing), 2001.

A. Teigen, S. Wang, B. Truong, and K. Bjerknes, Off-label and unlicensed medicines to hospitalised children in Norway, Journal of Pharmacy and Pharmacology, vol.14, issue.4, pp.432-440, 2017.
DOI : 10.1093/annonc/mdg031

C. Thompson, D. Lombardi, P. Sjostedt, and L. Squires, Best Practice Recommendations Regarding the Assessment of Palatability and Swallowability in the Development of Oral Dosage Forms for Pediatric Patients. Therapeutic Innovation & Regulatory Science, 2015.

C. Thompson, D. Lombardi, P. Sjostedt, and L. Squires, Industry Survey on Current Practices in the Assessment of Palatability and Swallowability in the Development of Pediatric Oral Dosage Forms, Therapeutic Innovation & Regulatory Science, vol.15, issue.5, pp.47542-47551, 2013.
DOI : 10.1177/2168479013500288

S. Thomson, C. Tuleu, I. Wong, S. Keady, K. Pitt et al., Minitablets: New Modality to Deliver Medicines to Preschool-Aged Children, PEDIATRICS, vol.123, issue.2, pp.2008-59, 2009.
DOI : 10.1542/peds.2008-2059

L. Tiger, The pursuit of pleasure. Boston : Little, Brown and Company, 1992.

T. Tomiyama, P. Gu, Y. Jin, D. Lutters, C. Kind et al., Design methodologies: Industrial and educational applications, CIRP Annals, vol.58, issue.2, pp.543-65, 2009.
DOI : 10.1016/j.cirp.2009.09.003

E. Topinková, J. Baeyens, J. Michel, and P. Lang, Evidence-Based Strategies for the Optimization of Pharmacotherapy in Older People, Drugs & Aging, vol.29, issue.5, pp.477-94, 2012.
DOI : 10.1007/s11096-006-9044-4

S. Tufféry, Data mining et statistique décisionnelle: l'intelligence des données: Editions Technip, 2010.

S. Turner, A. Nunn, K. Fielding, and I. Choonara, Adverse drug reactions to unlicensed and off-label drugs on paediatric wards: a prospective study, Acta Paediatrica, vol.78, issue.9, pp.965-973, 1999.
DOI : 10.1016/S0031-3955(16)32670-0

M. Uhari, L. Eskelinen, and J. Jokisalo, Acceptance of antibiotic mixtures by infants and children, European Journal of Clinical Pharmacology, vol.28, issue.4, pp.503-507, 1986.
DOI : 10.1007/BF00607970

T. Vallet, M. Lavarde, A. Aubert, and A. Pense-lheritier, Evaluation sensorielle et émotionnelle, un levier d'innovation pour le médicament, CONFERE

T. Vallet, F. Ruiz, A. Pense-lheritier, and A. Aoussat, Conception d'un outil d'évaluation de l'acceptabilité des médicaments, CONFERE

T. Vallet, F. Ruiz, A. Pense-lheritier, and A. Aoussat, Poster -Explorations of factors affecting medicine acceptability using standardized evaluations. 8th Conference of European Paediatric Formulation Initiative, 2016.

T. Vallet, F. Ruiz, A. Tadmouri, J. Blomkvist, A. Pense-lheritier et al., Preliminary development of a tool assessing the acceptability of medicines for paediatric use, International Journal of Pharmaceutics, vol.511, issue.2, pp.1146-1153, 2016.
DOI : 10.1016/j.ijpharm.2016.06.105

T. Vallet, E. Belissa, V. Boudy, F. Ruiz, R. Galénique et al., Standardisation de l'évaluation de l'acceptabilité des médicaments chez les patients de 65 ans et plus suivis à l'hôpital ou en EHPAD, 2017.

E. Van-de-vijver, K. Desager, A. Mulberg, S. Staelens, H. Verkade et al., Treatment of Infants and Toddlers With Cystic Fibrosis???related Pancreatic Insufficiency and Fat Malabsorption With Pancrelipase MT, Journal of Pediatric Gastroenterology and Nutrition, vol.53, issue.1, pp.61-65, 2011.
DOI : 10.1097/MPG.0b013e31820e208e

D. Van-riet-nales, K. De-jager, A. Schobben, T. Egberts, and C. Rademaker, The availability and age-appropriateness of medicines authorized for children in the Netherlands, British Journal of Clinical Pharmacology, vol.166, issue.3, pp.465-73, 2011.
DOI : 10.1007/s00431-006-0381-z

D. Van-riet-nales, B. De-neef, A. Schobben, J. Ferreira, T. Egberts et al., Acceptability of different oral formulations in infants and preschool children, Archives of Disease in Childhood, vol.5, issue.4 Pt 1, pp.725-756, 2013.
DOI : 10.1023/A:1012050931018

D. Van-riet-nales, M. Doeve, A. Nicia, S. Teerenstra, K. Notenboom et al., The accuracy, precision and sustainability of different techniques for tablet subdivision: Breaking by hand and the use of tablet splitters or a kitchen knife, International Journal of Pharmaceutics, vol.466, issue.1-2, pp.44-51, 2014.
DOI : 10.1016/j.ijpharm.2014.02.031

D. Van-riet-nales, J. Ferreira, A. Schobben, B. De-neef, T. Egberts et al., Methods of administering oral formulations and child acceptability, International Journal of Pharmaceutics, vol.491, issue.1-2, pp.261-268, 2015.
DOI : 10.1016/j.ijpharm.2015.06.047

T. Van-vliet, G. Van-aken, H. De-jongh, and R. Hamer, Colloidal aspects of texture perception, Advances in Colloid and Interface Science, vol.150, issue.1, pp.27-40, 2009.
DOI : 10.1016/j.cis.2009.04.002

J. Varni, M. Seid, and C. Rode, The PedsQL?: measurement model for the pediatric quality of life inventory. Medical care, pp.126-165, 1999.

J. Varni, M. Seid, and P. Kurtin, PedsQL??? 4.0: Reliability and Validity of the Pediatric Quality of Life Inventory??? Version 4.0 Generic Core Scales in Healthy and Patient Populations, Medical Care, vol.39, issue.8, pp.800-812, 2001.
DOI : 10.1097/00005650-200108000-00006

J. Varni, M. Seid, T. Knight, K. Uzark, and I. Szer, The PedsQLTM 4.0 Generic Core Scales: Sensitivity, responsiveness, and impact on clinical decision-making, Journal of Behavioral Medicine, vol.25, issue.2, pp.175-93, 2002.
DOI : 10.1023/A:1014836921812

J. Varni, T. Burwinkle, M. Seid, and D. Skarr, The PedsQL???* 4.0 as a Pediatric Population Health Measure: Feasibility, Reliability, and Validity, Ambulatory Pediatrics, vol.3, issue.6, pp.329-370, 2003.
DOI : 10.1367/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2

R. Venables, Determining the prevalence and nature of oral formulation-related barriers to medicines administration in paediatric patients suffering from chronic conditions: University of Birmingham, 2014.

R. Venables, H. Stirling, and J. Marriott, G406(P) Oral formulation-related barriers to medicines administration in children with chronic conditions: views of parents and young people, Archives of Disease in Childhood, vol.99, issue.Suppl 1, pp.169-70, 2014.
DOI : 10.1136/archdischild-2014-306237.387

R. Venables, H. Batchelor, H. Stirling, and J. Marriott, Barriers to administering non-oral formulations in a paediatric population: A semi-structured interview study, International Journal of Pharmaceutics, vol.497, issue.1-2, pp.12-19, 2015.
DOI : 10.1016/j.ijpharm.2015.11.010

A. Verrotti, G. Nanni, S. Agostinelli, E. Alleva, P. Aloisi et al., Effects of the abrupt switch from solution to modified-release granule formulation of valproate, Acta Neurologica Scandinavica, vol.3, issue.3, 2012.
DOI : 10.1016/S1525-5050(02)00037-9

C. Verrue, E. Mehuys, K. Boussery, J. Remon, and M. Petrovic, Tablet-splitting: a common yet not so innocent practice, Journal of Advanced Nursing, vol.53, issue.1, pp.26-32, 2011.
DOI : 10.18553/jmcp.2003.9.5.401

R. Weiland, H. Ellgring, and M. Macht, Gustofacial and Olfactofacial Responses in Human Adults, Chemical Senses, vol.20, issue.3 Pt 2, pp.841-53, 2010.
DOI : 10.2466/pms.1993.77.3f.1331

URL : https://academic.oup.com/chemse/article-pdf/35/9/841/1213201/bjq092.pdf

S. Winnick, D. Lucas, A. Hartman, and D. Toll, How Do You Improve Compliance?, PEDIATRICS, vol.115, issue.6, pp.718-742, 2005.
DOI : 10.1542/peds.2004-1133

K. Woertz, C. Tissen, P. Kleinebudde, and J. Breitkreutz, Taste sensing systems (electronic tongues) for pharmaceutical applications, International Journal of Pharmaceutics, vol.417, issue.1-2, pp.256-71, 2011.
DOI : 10.1016/j.ijpharm.2010.11.028

A. Wollner, A. Lecuyer, D. La-rocque, F. Sedletzki, G. Derkx et al., Acceptabilit??, compliance et rythme d???administration des antibiotiques oraux chez l???enfant, en ambulatoire, Archives de P??diatrie, vol.18, issue.5, pp.611-617, 2011.
DOI : 10.1016/j.arcped.2011.02.010

L. Young, F. Lawes, J. Tordoff, P. Norris, and D. Reith, Access to prescribing information for paediatric medicines in the USA: post-modernization, British Journal of Clinical Pharmacology, vol.352, issue.3, pp.341-347, 2009.
DOI : 10.1111/j.1365-2125.2008.03356.x

J. Zheng and M. Keeney, Taste masking analysis in pharmaceutical formulation development using an electronic tongue, International Journal of Pharmaceutics, vol.310, issue.1-2, pp.118-142, 2006.
DOI : 10.1016/j.ijpharm.2005.11.046

L. Zhu, R. Seburg, E. Tsai, S. Puech, and J. Mifsud, Flavor analysis in a pharmaceutical oral solution formulation using an electronic-nose, Journal of Pharmaceutical and Biomedical Analysis, vol.34, issue.3, pp.453-61, 2004.
DOI : 10.1016/S0731-7085(03)00651-4