Elaboration de librairies de molécules structurellement diversifiées à partir du squelette de l'acide kojique par des méthodes de synthèse micro-ondes et de flux continu

Abstract : The structure of kojic acid and its reactivity give the opportunity to make tranformations leading to the synthesis of different polycyclic compounds and structurally diversified. These heterocycles are obtained in several steps by typical reactions like [5+2] cycloaddtions, Diels-Alder reactions, tandem [5+2]/[4+2] cycloadditions, 3 compounds reactions or the use of lithiens. The use of specific equipments like microwave equipment and continuous-flow equipment give the opportunnity to obtain target molecules. Compounds libraries will be test for a biological activity.
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Ludovic Leleu. Elaboration de librairies de molécules structurellement diversifiées à partir du squelette de l'acide kojique par des méthodes de synthèse micro-ondes et de flux continu. Autre. PSL Research University, 2017. Français. ⟨NNT : 2017PSLEC005⟩. ⟨tel-01807666⟩

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