Fonctionnalisation directe de composes heteroaromatiques par la chimie des xanthates

Abstract : The late introduction of pharmacologically relevant groups before evaluating the biological properties of potent targets enables a faster and efficient exploration of their chemical space. This has been particularly studied and applied on heteroaromatic rings which are key scaffolds in medicinal and agrochemical research. In this context, the radical chemistry of xanthates has emerged as an useful tool, thanks to its high functional group compatibility. The xanthate-mediated addition of tertiary and secondary alkyl radicals to heteroarenes enables the easy functionalization of heteroaromatic rings as well as more decorated structures, such as marketed drugs or agrochemicals.
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Vincent Revil Baudard. Fonctionnalisation directe de composes heteroaromatiques par la chimie des xanthates. Chimie organique. Université Paris-Saclay, 2018. Français. ⟨NNT : 2018SACLX064⟩. ⟨tel-01905385⟩

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