Skip to Main content Skip to Navigation
Theses

Biocapteurs Electrochimiques de microARNs pour le Diagnostic Médical

Abstract : MicroRNAs (miRNA), which are 21 to 25 base length RNAs, are the last discovered class of genetic expression regulators. Nowadays, about 1500 human miRNAs have been identified. MiRNA are biosensors of many pathologies (cancers, cardiovascular, auto-immune (multiple sclerosis),neurodegenerative (Alzheimer, Parkinson)and infectious diseases (AIDS, CHIKV)) and the doctoral project ambition is to develop an electrochemical biosensor prototype for miRNA direct detection in biological human fluids (serum) at very low concentrations, from picomolar (10^-12 M) to subattomolar (10^-16 M), without amplification by polymerisation chain reaction (PCR).
Document type :
Theses
Complete list of metadatas

https://pastel.archives-ouvertes.fr/tel-01941402
Contributor : Abes Star :  Contact
Submitted on : Saturday, December 1, 2018 - 1:06:21 AM
Last modification on : Tuesday, October 20, 2020 - 11:28:53 AM
Long-term archiving on: : Saturday, March 2, 2019 - 12:26:05 PM

File

dif_80404_guillon.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-01941402, version 1

Citation

François-Xavier Guillon. Biocapteurs Electrochimiques de microARNs pour le Diagnostic Médical. Chimie thérapeutique. Université Paris sciences et lettres, 2017. Français. ⟨NNT : 2017PSLEC002⟩. ⟨tel-01941402⟩

Share

Metrics

Record views

294

Files downloads

724