Biocapteurs Electrochimiques de microARNs pour le Diagnostic Médical

Abstract : MicroRNAs (miRNA), which are 21 to 25 base length RNAs, are the last discovered class of genetic expression regulators. Nowadays, about 1500 human miRNAs have been identified. MiRNA are biosensors of many pathologies (cancers, cardiovascular, auto-immune (multiple sclerosis),neurodegenerative (Alzheimer, Parkinson)and infectious diseases (AIDS, CHIKV)) and the doctoral project ambition is to develop an electrochemical biosensor prototype for miRNA direct detection in biological human fluids (serum) at very low concentrations, from picomolar (10^-12 M) to subattomolar (10^-16 M), without amplification by polymerisation chain reaction (PCR).
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François-Xavier Guillon. Biocapteurs Electrochimiques de microARNs pour le Diagnostic Médical. Chimie thérapeutique. PSL Research University, 2017. Français. ⟨NNT : 2017PSLEC002⟩. ⟨tel-01941402⟩

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