Skip to Main content Skip to Navigation

Mechanical characterization and numerical modeling of aortic valve tissues

Abstract : This PhD thesis aims to develop experimental and numerical tools for the mechanical characterization and the numerical modeling of natural or artificial aortic valve tissues. These tools are intended to be used for the development of new biomimetic polymeric implants. Nowadays, almost 300 000 prosthetic valves are implanted every year worldwide. Two families of prosthetic valves are currently available~: mechanical and biological prostheses. However, both solutions suffer from major drawbacks. In this context, polymeric prostheses represent a promising alternative but currently suffer from insufficient material properties to be suitable for a long--lasting implantation. In this work, an experimental protocol using biaxial tensile tests together with full--field surface measurement and confocal microscopy is proposed. Since numerical simulation is intended to assist the design phase of new implants by predicting their mechanical behavior, a structure and a fluid solver are developed and coupled. Using experimental results, implemented constitutive models are calibrated through an inverse analysis procedure.
Complete list of metadata

Cited literature [144 references]  Display  Hide  Download
Contributor : ABES STAR :  Contact
Submitted on : Monday, May 13, 2019 - 10:51:53 AM
Last modification on : Wednesday, November 17, 2021 - 12:28:33 PM
Long-term archiving on: : Wednesday, October 2, 2019 - 1:48:24 AM


Version validated by the jury (STAR)


  • HAL Id : tel-02127058, version 1


Colin Laville. Mechanical characterization and numerical modeling of aortic valve tissues. Materials. Université Paris sciences et lettres, 2017. English. ⟨NNT : 2017PSLEM069⟩. ⟨tel-02127058⟩



Record views


Files downloads