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From X-ray tomography to the first X-ray plenoptic camera for nanoparticles bio-localization

Abstract : X-ray tomography is a non-invasive imaging technique that allows producing 3D images following the acquisition of multiple 2D images at many angles. In particular, X-ray Phase-Contrast Tomography (XPCT) has been exploited for resolving the biodistribution of metal-based theranostic nanoparticles (NPs) in mice. These NPs are widely used as radiosensitizers for researches on cancer therapies and, recently to mark amyloid plaques in Alzheimer’s disease in mice. Thanks to the high brightness of ESRF synchrotron, high resolution XPCT images were obtained and thus processed for producing 3D models of mice organs doped with gadolinium, gold or platinum NPs.In parallel, in the framework of a European project, named VOXEL (Volumetric X-ray Extremely Low dose), a compact desktop-size soft X-ray microscope was developed aiming at biological cell imaging. The microscope was designed to be suitable in the so-called “water window” spectral range, where a natural good contrast of the cellular structures is achievable. The microscope was conceived to perform plenoptic imaging, a technology currently tested only in the visible domain. This device is composed of a main lens and a microlens array coupled to a detector, allowing recording the spatial and the angular components of the light rays travelling up to the detector and thus enabling producing 3D images in a single exposure. By adapting this disrupting technology to X-rays, a huge impact for bio-medical applications is foreseen, since it would lead to a drastic decrease of the dose absorbed by samples, compared to traditional X-ray tomography methods.
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Submitted on : Tuesday, May 21, 2019 - 1:02:59 AM
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  • HAL Id : tel-02135045, version 1


Elena Longo. From X-ray tomography to the first X-ray plenoptic camera for nanoparticles bio-localization. Imaging. Université Paris Saclay (COmUE), 2018. English. ⟨NNT : 2018SACLX104⟩. ⟨tel-02135045⟩



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