Imagerie Optique Multimodale des tissus par Tomographie Optique Cohérente Plein Champ

Abstract : Full filed optical coherence tomography is a microscopy imaging technique allowing to image a specific slice in a scattering medium, in depth. This technique has been used for the diagnosis of biopsy in cancerology. This technique could be an efficient and fast way to diagnose excised tissues during surgery. This would avoid numerous reoperations procedures. These reoperations are necessary when a pathologist suspects cancerous tissue to still be present in the patient, based on histological slide examination.FFOCT has shown promising results for that purpose. Nevertheless, this technique only gives a morphological contrast of tissues, which is not enough for applying some diagnostic criteria such as cell morphology or cell density.We developed a new imaging modality based on FFOCT allowing to reveal metabolic contrast in tissues at the subcellular scale. This contrast reveals cells previously indistinguishable with FFOCT. We also used this quantitative metric to propose tools to facilitate diagnosis, using machine learning approaches.
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Clément Apelian. Imagerie Optique Multimodale des tissus par Tomographie Optique Cohérente Plein Champ. Physique Médicale [physics.med-ph]. PSL Research University, 2017. Français. ⟨NNT : 2017PSLET009⟩. ⟨tel-02286212⟩

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