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Adaptive optics in full-field spatially incoherent interferometry and its retinal imaging

Abstract : This thesis follows the study and development of an adaptive optics full-field optical coherence tomography (AO-FFOCT) system, aiming for high resolution en face human retinal imaging. During the quantification of the effects of geometrical aberrations on the FFOCT system performance, it is shown that, with spatially incoherent illumination, the lateral resolution of FFOCT is insensitive to aberrations, which only cause the FFOCT signal reduction. Since low order aberrations like myopia and astigmatism dominate in human eye, a non-conjugate AO configuration by using transmissive wavefront corrector is suggested and applied for low order aberrations correction to simplify the AO-FFOCT system. Wavefront corrections are done with a wavefront sensorless method by using FFOCT signal level as the metric. Experiments with scattering samples and artificial eye model are conducted to demonstrate the feasibility of the customized AO-FFOCT system for aberration correction. In order to resolve the eye motion effects and employ real-time matching of the optical path lengths of the two interferometric arms in FFOCT, a system combination of traditional spectral-domain OCT (SDOCT) with FFOCT is adopted. With this combined system, high resolution FFOCT cellular retinal imaging is achieved in human eye in vivo for the first time.
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Submitted on : Thursday, October 10, 2019 - 1:08:07 PM
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  • HAL Id : tel-02310664, version 1


Peng Xiao. Adaptive optics in full-field spatially incoherent interferometry and its retinal imaging. Human health and pathology. Université Paris sciences et lettres, 2017. English. ⟨NNT : 2017PSLET015⟩. ⟨tel-02310664⟩



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