, Synthesis of a,g-disubstituted-a,b-unsaturated lactams????????????, p.276

.. ?. Substrate, , p.315

, Post-functionalization of allylated g-lactams???????????????????, p.343

C. Nmr-;-s,-2c and . Ar, 3 (s, C 17 ), 131.2 (s, C Ar ), 129.4 (s, C Ar ), 129.3 (d, J = 31, MHz, vol.141, issue.101

, HRMS (ESI) m/z: calculated for C 39 H 30 F 3 NONa [M+Na] + : 608.2172, found: 608.2170. (R)-3-Cinnamyl-3-phenyl-5-(o-tolyl)-1-(4-(trifluoromethyl)benzyl)-1,3-dihydro-2H-pyrrol-2-one

, MW: 523.2123 g.mol -1 Molecular Formula: C 34 H 28 F 3 NO

, Compound II.3n was synthesized according to the general method from 2-[(tertbutyldimethylsilyl)oxy]-3-phenyl-5-(o-tolyl)-1-[4-(trifluoromethyl)ben-zyl]-1H pyrr-ole II.1n (104.2 mg, 0.2 mmol) and cinnamyl benzoate II

I. I. Compound, 3n was isolated as a white solid (87.0 mg, 83%) after purification by flash column chromatography over silica gel

. Mp, , pp.88-89

, 5 (c = 3.15, CHCl 3 ), ee = 68% (determined by SFC)

H. Nmr-;-m,-2h, 2. Ar-;-m, and H. Ar, 26 -Compound II.3u was synthesized according to the general method from 3,5-diphenyl-1-[4-(trifluoromethyl)benzy]]-1,5-dihydro-2H-pyrrol-2-one II.1e (101.4 mg, 0.2 mmol) and (E)-3-(naphthalen-2-yl)allyl benzoate II, MHz, vol.7, issue.400

I. I. Compound, 3u was isolated as a white solid (92.4 mg, 79%) after purification by flash column chromatography over silica gel

, 5 (c = 2.67, CHCl 3 ), ee = 84% (determined by SFC)

, SFC: OD-H column, pressure = 100 bar, eluent = CO 2 /MeOH, vol.80

H. Nmr-;-m, 3. , and H. Ar, 400 MHz, CDCl 3 ) ? 7.83 -7.75 (m, 3H, H Ar ), vol.7, pp.68-75

2. Hz and H. Ar, 6.74 (d, J = 15.7 Hz, 1H, H 17 ), vol.6

1. Hz,

C. Nmr-;-c-ar-;-s,-2c, . Ar-;-s,-2c, . Ar-;-s,-2c, and . Ar, 1 (s, C Ar ), 131.2 (s, C Ar ), 129.4 (s, C Ar ), 129.3 (d, J = 32.2 Hz, C 14 ), MHz, vol.141, issue.101

, HRMS (ESI) m/z: calculated for C 37 H 28 F 3 NOH [M+H] + :560.2196

C. Nmr-;-s,-2c, . Ar-;-s,-2c, . Ar-;-s,-2c, . Ar-;-s,-2c, and . Ar, 4 (s, C Ar ), 127.1 (s, C Ar ), 126.8 (s, 2C, C Ar ), 125.9 (s, C Ar ), MHz, vol.142, issue.101

, HRMS (ESI) m/z: calculated for C 32 H 31 NOH [M+H]: 446.2478, found: 446.2487. The data of minor diastereomer of II, vol.33, p.39

, CHCl 3 ), ee = 84% (determined by SFC)

, SFC: AD-H column, pressure = 100 bar, eluent = CO 2 /MeOH (85:15), flow rate

H. Nmr, 400 MHz, CDCl 3 ) ? 7.57 (dd, J = 7.6, 2.4 Hz, 2H, H Ar ), 7.36 -7.18 (m, 13H, H Ar ), 7.10 -7.05 (m, 5H, H Ar ), vol.5

C. Nmr-;-s,-2c, . Ar-;-s,-2c, and . Ar, 4 (s, 2C, C Ar ), 126.8 (s, 2C, C Ar ), 126.6 (s, C Ar ), MHz, vol.142, issue.101

2. Ar, Synthesis of pyrrolidine derivatives II.6 from the a-allylated product II.3c: 137.0 (s, C Ar ), 135.0 (s, C 16 ), 134.0 (s, C Ar ), 131.5 (s, C Ar ), HRMS (ESI) m/z: calculated for C, vol.129

, HRMS (ESI) m/z: calculated for C

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