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Role of the actomyosin cytoskeleton on the synaptic effects of the type-1 cannabinoid receptor (CB1R)

Abstract : Recently published results from the hosting team suggest that activation of the type-1 cannabinoid receptor (CB1R) induces significant structural remodelling of neurons through modulation of the actomyosin cytoskeleton. This thesis will aim to further characterize the functional consequences of the influence of CB1R activation in the modulation of the actomyosin cytoskeleton, both at the synaptic level. This aim will be accomplished firstly through pharmacological dissection of the molecular pathways linking CB1R modulation of synaptic function to cytoskeletal remodelling, using both conventional time-lapse videomicroscopy of cultured hippocampal neurons, as well as through superresolution imaging of dynamic changes in presynaptic structure under CB1R activation. Results stemming from this project will potentially provide a new molecular pathway underlying well established functions of CB1R as well as providing a novel framework through which to better understand and treat the effects of cannabinoids in the development of such illnesses as schizophrenia.
Keywords : Synapse Cb1r Actomyosin
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Maureen Mcfadden. Role of the actomyosin cytoskeleton on the synaptic effects of the type-1 cannabinoid receptor (CB1R). Neurons and Cognition [q-bio.NC]. Université Paris sciences et lettres, 2018. English. ⟨NNT : 2018PSLET006⟩. ⟨tel-02518809⟩

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